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- Identification of Daily Activites and Environments Based on the AdaBoost Method Using Mobile Device DataPublication . Ferreira, José M.; Pires, Ivan; Marques, Gonçalo; Garcia, Nuno M.; Zdravevski, Eftim; Lameski, Petre; Flórez-Revuelta, Francisco; Spinsante, SusannaUsing the AdaBoost method may increase the accuracy and reliability of a framework for daily activities and environment recognition. Mobile devices have several types of sensors, including motion, magnetic, and location sensors, that allow accurate identification of daily activities and environment. This paper focuses on the review of the studies that use the AdaBoost method with the sensors available in mobile devices. This research identified the research works written in English about the recognition of daily activities and environment recognition using the AdaBoost method with the data obtained from the sensors available in mobile devices that were published between 2012 and 2018. Thus, 13 studies were selected and analysed from 151 identified records in the searched databases. The results proved the reliability of the method for daily activities and environment recognition, highlighting the use of several features, including the mean, standard deviation, pitch, roll, azimuth, and median absolute deviation of the signal of motion sensors, and the mean of the signal of magnetic sensors. When reported, the analysed studies presented an accuracy higher than 80% in recognition of daily activities and environments with the Adaboost method.
- Partilha do conhecimento tácito nas organizações sem fins lucrativosPublication . Oliveira, Márcio José Sol Pereira; Pinheiro, Paulo GonçalvesOs estudos na área da aprendizagem organizacional por incremento da partilha de conhecimento tácito, direcionados para as organizações sem fins lucrativos são escassos, por oposição ao que se verifica no setor privado e público. A crescente importância do terceiro setor e das suas instituições, no estabelecimento de uma sociedade mais justa e equilibrada, combatendo assimetrias, justifica a atenção da comunidade académica, tendo em vista o apuramento e adoção das melhores práticas que visem o cumprimento das suas missões. A opção do estudo de caso de organizações como os corpos de bombeiros (CBs) portugueses, ímpares na sua ação e identidade, acompanha a necessidade cada vez mais reconhecida pela sociedade portuguesa, em capacitar estas organizações de diferentes formas de aprendizagens que tragam um reforço de competências, e o aperfeiçoamento dos seus desempenhos. Os eventos trágicos ocorridos nos últimos anos neste país, nomeadamente em matéria de grandes incêndios colocou os CBs no centro desta questão. Assim, focando o estudo na partilha de conhecimento tácito, como forma de reforçar a aprendizagem organizacional nestas organizações em Portugal e tomando como estudo de caso os bombeiros voluntários Portugueses, elencámos como objetivos: I) Apurar a prevalência de indicadores de partilha de conhecimento tácito nos bombeiros voluntários Portugueses, II) Identificar os fatores mais relevantes para que essa partilha ocorra, III) Apurar a prevalência dos facilitadores “intenção” e “disponibilidade” a essa partilha, IV) Identificar as principais barreiras à partilha de conhecimento tácito, V) Identificar as tipologias de barreiras à partilha de conhecimento tácito nos bombeiros voluntários Portugueses, VI) Apurar os perfis dos bombeiros voluntários em Portugueses face à partilha de conhecimento tácito, VII) Determinar a influência das lições apreendidas na partilha de conhecimento tácito nos bombeiros voluntários Portugueses, VIII) Criar uma matriz de diagnóstico relativo à partilha de conhecimento tácito nas organizações em estudo e IX) Elaborar uma matriz de atuação, tendo em vista a eliminação das barreiras mais prevalentes. Uma revisão da literatura sobre partilha de conhecimento tácito permitiu a identificação de indicadores, facilitadores e barreiras à partilha deste conhecimento. Foi possível ainda apurar um conjunto de indicadores que visam a compreensão a partilha de conhecimento tácito por via das lições apreendidas na sequência de eventos operacionais marcantes. Seguiu-se uma metodologia mista onde se combinaram recolhas de dados via questionários e entrevistas, cujo tratamento permitiu apurar a prevalência de indicadores, facilitadores, barreiras e lições apreendidas. O tratamento dos dados permitiu encontrar as respostas para os perguntas de partida e objetivos anteriormente enunciados. Foi possível perceber quais os principais indicadores e fatores que influenciam a partilha do conhecimento tácito, identificar a prevalência dos facilitadores em estudo, apurar as principais barreiras que se levantam a esta partilha de conhecimento e as suas tipologias, identificar e caraterizar os diferentes grupos de bombeiros face à partilha de conhecimento tácito, determinar a influencia das lições apreendidas na sequência de eventos operacionais marcantes, na partilha deste conhecimento e, finalmente, elaborar uma matriz de diagnóstico de partilha de conhecimento tácito para este tipo de organizações e outra matriz de atuação, tendo em vista a eliminação das barreiras mais prevalentes. O estudo não termina sem que antes sejam apresentadas as limitações do estudo e feitas recomendações para investigações futuras.
- Religião e SociedadePublication . Cenci, Rosangela; Rodrigues, Donizete AparecidoA tese trata da relação estreita e complexa entre religião e sociedade, objetivando compreender e analisar, sociologicamente, os fatores sociais e religiosos determinantes à reestruturação institucional de um convento franciscano católico feminino (Irmãs Franciscanas Missionárias de Maria Auxiliadora - IFMMA) na contemporaneidade. O arcabouço teórico que acompanhou a elaboração deste estudo é constituído pelas teses dos principais sociólogos clássicos e modernos quando tematizam a discussão sociológica contemporânea, com enfoques nas funções sociais da religião (Durkheim, Weber, Marx, Bourdieu e Berger), construtos da compreensão estrutural pós-burocrática das organizações numa perspectiva weberiana e a trajetória institucional (Hall e Taylor). O estudo foi investigativo qualitativo, com dados coletados a partir de entrevistas semiestruturadas e presenciais com membros representantes da Instituição Religiosa (IR), observação participante, notas do diário de campo e documentos institucionais com a representatividade de todos os membros. A análise realizada por narrativa reflexiva e categorias conceituais apontou que o processo de reestruturação e o posicionamento estão amplamente direcionados pelos fatores sociais e religiosos, os quais podem agir associadamente para contribuir à busca de alternativas para o reposicionamento da missão institucional. Há tensões entre os membros referentes à perspectiva de futuro. É unânime o entendimento sobre a necessidade de mudança, mesmo constando resistências. Porém, o sistema de regras, contornos, os padrões simbólicos e o estado de anomia institucional faz com que a mudança tenha ênfases ad intra, numa perspectiva virtuosa, mas estrutural. Sopesa a necessidade de pensar o reconhecimento aos membros da contemporaneidade que seguem as IR, mediante carreiras profissionais significativas para missões, para que se sintam valorizados na sua doação diante das contrariedades impostas pelos fatores sociais atuais. O modelo atual de vida missionária não responde e não possui mais credibilidade. Pode-se afirmar que a instituição religiosa terá um novo habitus e um novo habitus de religiosos, uma forma de vida com uma ótica de impacto abrangente para mundo e com soluções alternativas em conjunto, universais para a sobrevivência e a sustentabilidade da humanidade. As religiosas das novas gerações serão mais inspiradas no que as une do que as separa. Serão pluralistas, ecumênicas, cientistas e ousadas à mendicância de Francisco ou à pobreza de Clara de Assis. Terão a vivência moderna de uma economia racional consciente, circulante e solidária para a vida, a justiça social, a paz e o bem, como compromissos revisitados para viver a consagração no contexto moderno. A fundamentação, marco jurídico, para esta forma de vida será Reinocêntrica.
- Cuidados centrados na pessoa idosa em Portugal: Abordagens e instrumentos de avaliaçãoPublication . Barbosa, Maria Miguel; Afonso, Rosa Marina; Paúl, Constança; Yanguas, JavierOs processos tradicionais de prestação de cuidados a idosos têm sido dominados por paradigmas de base assistencial e curativa que tendem a centrar o seu foco na doença/défices e a apresentar uma organização rígida, práticas uniformizadas e procedimentos padronizados (Koren, 2010; World Health Organization, 2015). Este tipo de modelos tem demonstrado sinais de baixa sustentabilidade no respeito pelos direitos das pessoas idosas e na promoção de cuidados de qualidade (World Health Organization, 2015). [...]
- Repensando Novas Estratégias e Cenários para a Construção do ConhecimentoPublication . Rocha, Maria Cecília Mendonça Melo da; Branco, Maria Luísa Frazão Rodrigues; Simões, Maria de Fátima de Jesus; Falbo, GilliattA educação a distância online vem se tornando, progressivamente, uma estratégia de ensino que busca atender a um público diferenciado em toda sua especificidade. A desconstrução das barreiras de tempo e espaço e seu alto poder de interação a configura como uma nova ferramenta pedagógica para resolver os problemas da educação, caracterizando-se como facilitadora do processo de ensino-aprendizagem. No entanto, a educação a distância é vista com desconfiança no sentido de democratizar a educação e formar cidadãos aptos a resolver os problemas cada vez mais complexos. Isso ocorre pelo caráter instrumental que predomina nestes cursos, muitas vezes voltados a formar pessoas a partir da autoinstrução, tendo em vista a capacitação voltada para a inserção no mercado de trabalho. Esta pesquisa teve por objetivo principal identificar quais estratégias moviam os estudantes do 5º ano da graduação do curso de Medicina para atingir os objetivos da aprendizagem no ambiente virtual. Este estudo é definido como pesquisa qualitativa, identificada como estudo de caso, orientado por uma perspectiva crítica. A fundamentação teórica é ancorada na Teoria Pragmática do Conhecimento, no sócio construtivismo de Vygotsky e no seu conceito de Zona de Desenvolvimento Proximal (ZDP). O cenário de investigação está inserido na proposta Problem Based Learning (PBL), pensado incompatível com a autoinstrução. Assim procuramos investigar se existia possibilidade de diálogo efetivo entre a autoinstrução e metodologias ativas, buscando entender se o desenvolvimento da autonomia discente pode ser inibido pela proposta de um curso a distância no modelo auto instrucional e, sobretudo, entender como estudantes que estão inseridos no contexto de metodologia ativa como o PBL se sentem contemplados na sua construção de conhecimento a partir da autoinstrução. Os resultados mostraram que, com relação às estratégias desenvolvidas pelos estudantes, estas – apesar de serem individuais - estão sempre vinculadas à motivação do tutor. A estruturação do material didático, contextualizado na prática dos estudantes, pensado previamente pelo tutor para ser o mediador das ações no contexto do curso online, foi determinante para o desenvolvimento das estratégias, levando-nos à compreensão de que o desenvolvimento do material voltado para cursos de educação a distância deve ser pensado a partir da concepção que se tem do processo de mediação. Em cursos auto instrucionais, esta escolha se reveste de uma importância maior, uma vez que o material didático e as ferramentas de tecnologia servirão de mediador entre aprendizes e conteúdo. Quando existe contextualização e significação dos conteúdos, pode-se desconstruir exemplos, modelos e modalidades.
- Prostate cancer cells metabolism on the interplay of androgenic regulation and metabolic environmentPublication . Cardoso, Henrique José Matos Morão Mingote; Socorro, Sílvia Cristina da Cruz Marques; Madureira, PatríciaProstate Cancer (PCa) is one of the most common cancer in men and represents the fifth leading cause of cancer deaths. In an initial phase of PCa, the so-called androgen-sensitive stage, PCa cells are extremely dependent on androgens actions to survive and proliferate. This condition allows the effectiveness of androgens deprivation therapy (ADT) that reduce the circulating levels of androgens or block their action. The continuous administration of ADT renders PCa cells resistant to treatment, becoming capable of survive and metastasize even in the absence or very low circulating levels of androgens. At this moment, it is reached the stage of castrate-resistant prostate cancer (CRPC), a condition with high mortality rates and treatment limitations. In the last years, a substantial amount of data showed that cancer cells have the ability of reprogramming metabolism to survive and metastasize. Warburg studies were pioneer showing that tumour cells predominantly use glycolysis for obtaining energy, in detriment of oxidative phosphorylation, with the production of high amounts of lactate. These findings opened the door to the metabolic adaptation being considered a hallmark of cancer. Currently, it is accepted that mitochondrial oxidative phosphorylation and glycolysis, support tumour cells survival and growth. Primary PCa cases differ from other cancer types by the fact that is less glycolytic, and the idea that predominantly use fatty acids and glutamine as energy substrates has been gaining consistency. Indeed, glycolysis is only overactivated in more advanced stages of the disease, in CRPC. However, the understanding of how each metabolic pathway sustains PCa cells survival and growth still is incomplete. Besides the recognized functions as the main drivers of PCa survival and growth, androgens have been indicated as metabolic regulators in PCa, modulating glycolysis and cell lipid handling. Nevertheless, there are several issues in the role of androgens controlling PCa metabolism that need to be clarified. Although efforts have been made in recent years to develop new drugs for PCa treatment, namely, for CRPC, they have shown limited duration of clinical and survival benefits. Following the trend observed in other cancer types, treatment approaches targeting metabolism also have been explored in the case of PCa and CRPC. However, there are important knowledge gaps in the understanding of PCa cells metabolism that should be fulfilled to improve its efficacy and to avoid resistance and bypassing metabolic pathways. The main goal of this thesis was to clarify the role androgens and the metabolic environment in shaping PCa metabolism, and how this interplay can affect PCa cell fate. The present thesis first established the PCa cells dependency on the different metabolic pathways (glycolysis, glutaminolysis and lipid metabolism). It was demonstrated that CRPC cells have higher metabolic rates being more glycolytic than the androgen-sensitive cells, especially the PC3 cells, which also showed a higher capacity to oxidize glutamine. Androgen-responsive LNCaP cells displayed a higher capacity for using fatty acids as mitochondrial fuels. These findings allowed to demonstrate a differential dependency and capacity of fuel use between androgen-sensitive and CRPC cells. Next, we determined the relevance of glutaminolysis for PCa cells survival and growth and the effect of androgens in the regulation of glutamine metabolism. Treatment of PCa cells with 5α-dihydrotestosterone (DHT, 10nM) potentiated glutamine metabolism in PCa cells, whereas the inhibition of glutaminase activity diminished cell viability and migration, and increased apoptosis, particularly in the CRPC. Moreover, cotreatment with glutaminase inhibitor BPTES and the anti-androgen bicalutamide had a synergic effect suppressing LNCaP cells viability, which highlights the benefit of co-targeting androgen receptor and glutamine metabolism in PCa treatment. Glutaminolysis inhibition also had an impact on glycolysis and lipid metabolism. The role of androgens in regulating lipid metabolism and the influence of these hormones and LDL-cholesterol modulating PCa cells fate were evaluated. DHT upregulated the expression of fatty acid synthase and carnitine palmitoyltransferase 1A in androgensensitive PCa cells. LDL-cholesterol enrichment increased PCa cells viability, proliferation, and migration dependently on DHT. This in vitro approach supports clinical and epidemiological data linking obesity and cholesterol with PCa, and first implicated androgens in this relationship. Finally, we investigated the effect of different glucose availability on the PCa cells response to therapy. For this purpose, it was used the receptor tyrosine kinase inhibitor imatinib and two cell line models of CRPC. Higher glucose availability improved the effectiveness of imatinib suppressing survival and growth of CRPC cells Moreover, imatinib treatment stimulated the glycolytic metabolism of CRPC cells. Overall, it was showed that hyperglycemia, the main serum alteration in diabetic patients, potentiated the effects of imatinib in CRPC cells, which raises the curiosity about the efficacy of this drug for treatment of castration-resistant diabetic patients. In conclusion, the main findings of this thesis confirmed the crucial actions of androgens in regulating the metabolism of PCa cells. These effects were pivotal for PCa cells obtaining energy and triggered proliferation and metastasis. Another innovative result of the present thesis was the identification of the cholesterol and androgens interplay in inducing survival and invasiveness features of PCa cells. Moreover, this dissertation demonstrated the flexibility of PCa cells using different energy sources and contributed to a better understanding of the role of lipids and glutamine in PCa. The molecular mechanism underlying the metabolic support of cancer cell survival and growth were highlighted. Overall, the information gathered in this thesis supports the metabolic environment and androgens as “co-authors” orchestrating the reprogramming of PCa and cancer development. Further research on this interplay could be a basis for the development of new treatment approaches for PCa.
- Review on techniques and treatments toward the mitigation of the chilling injury of peachesPublication . Rodrigues, Cristina; Gaspar, Pedro Dinis; Simões, Maria; Silva, Pedro D.The peach is a stone fruit with a very juicy flesh, smooth skin, and a taste that satisfies the most demanding palate. The quality of this fruit is usually determined by texture, appearance, scent, flavor, and nutritional value. Peaches are very sensitive fruits, which deteriorate and ripen very quickly at environment temperature. Cold conservation is the usual method for delaying the product deterioration, but this process may cause chilling injury (CI). This damage is a physiological low temperaturedriven disturbance, which affects the fruit quality, reducing its storage and shelf life and impairing its organoleptic characteristics. The characteristics of the main techniques and treatments to mitigate the CI such as: temperature-dependent, controlled and/or modified atmosphere, intermittent warming (IW), ethylene inhibitors, Glycine Betaine (GB), Methyl Jasmonate (MeJA) treatments, exposure to ultraviolet radiation (UV) and genetic determination are reviewed. Its consequences are evaluated and the ideal conservation air temperature and humidity are set to enhance organoleptic characteristics.
- Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidencePublication . Bousquet, Jean; Schünemann, Holger J; Togias, Akdis; Bachert, Claus; Erhola, Martina; Hellings, Peter; Klimek, Ludger; Pfaar, Oliver; Wallace, Dana; Ansotegui, Ignacio; Agache, Ioana; Devillier, Philippe; Dykewicz, Mark; Ebisawa, Motohiro; Fauquert, Jean-Louis; Fokkens, Wytske J; Fonseca, Joao A; Fontaine, Jean-François; Gemicioglu, Bilun; van Wijk, Roy Gerth; Haahtela, Tari; Halken, Susanne; Ierodiakonou, Despo; Iinuma, Tomohisa; Ivancevich, Juan-Carlos; Jutel, Marek; Kaidashev, Igor; Khaitov, Musa; Kalayci, Omer; Kleine Tebbe, Jorg; Kowalski, Marek L; Kuna, Piotr; Kvedarienė, Violeta; La Grutta, Stefania; Linnemann, Désirée Larenas; Lau, Susanne; Laune, Daniel; Le Thi Tuyet, Lan; Lieberman, Philipp; Lodrup Carlsen, Karin C; Lourenço, Olga; Marien, Gert; Carreiro-Martins, Pedro; Melén, Erik; Menditto, Enrica; Neffen, Hugo; Mercier, Gregoire; Mosgues, Ralph; Mullol, Joaquim; Muraro, Antonella; Namazova-Baranova, Leyla; Novellino, Ettore; O'Hehir, Robyn; Okamoto, Yoshitaka; Ohta, Ken; Park, Hae-Sim; Panzner, Petr; Passalacqua, Giovanni; Pham-Thi, Nhan; Price, David; Roberts, Graham; Roche, Nicolas; Rolland, Christine; Rosario, Nelson; Ryan, Dermot; Samolinski, Boleslaw; Sanchez-Borges, Mario; Scadding, Glenis K; Shamji, Mohamed H; Sheikh, Aziz; Todo-Bom, Ana; Toppila-Salmi, Sanna; Tsiligianni, Ioana; Valentin Rostan, Marylin; Valiulis, Arunas; Valovirta, Erkka; Ventura, Maria Teresa; Walker, Samantha; Waserman, Susan; Yorgancioglu, Arzu; Zuberbier, Torsten; Bedbrook, Anna; Bergmann, Karl-Christian; Bewick, Mike; Bonniaud, Philippe; Bosnic-Anticevich, Sinthia; Bossé, Isabelle; Bouchard, Jacques; Boulet, Louis-Philippe; Brozek, Jan; Brusselle, Guy; Calderon, Moises A; Canonica, Walter G; Caraballo, Luis; Cardona, Vicky; Casale, Thomas; Cecchi, Lorenzo; Chu, Derek K; Costa, Elísio; Cruz, Alvaro A; Czarlewski, Wienczyslawa; D'Amato, GennaroThe selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. However, there is an increasing trend toward use of real-world evidence to inform clinical practice, especially because randomized controlled trials are often limited with regard to the applicability of results. The Contre les Maladies Chroniques pour un Vieillissement Actif (MACVIA) algorithm has proposed an allergic rhinitis treatment by a consensus group. This simple algorithm can be used to step up or step down allergic rhinitis treatment. Next-generation guidelines for the pharmacologic treatment of allergic rhinitis were developed by using existing GRADE-based guidelines for the disease, real-world evidence provided by mobile technology, and additive studies (allergen chamber studies) to refine the MACVIA algorithm.
- Inorganic-based drug delivery systems for cancer therapyPublication . Rodrigues, Ana Carolina Félix; Alves, Cátia; Lima-Sousa, Rita; Moreira, André F.; Diogo, Duarte de Melo; Correia, I.J.The aging of the worldwide population has associated an increased incidence and prevalence of several pathologies, such as cancer, skin lesions, and neurological disorders. To improve the therapeutic outcome, researchers have been involved in the development of new disruptive therapeutic products that provide personalized and more efficient healthcare solutions. Among them, inorganic nanoparticles such as those made of gold, silica, or graphene-based materials have been used by researchers and clinicians for cancer therapy. Inorganic nanoparticles present unique size- and shape-dependent physicochemical and optical properties that in conjugation with high loading capacities prompted their application as therapeutics, drug delivery vehicles, and imaging agents. Additionally, these structures can also be conjugated with targeting moieties or stealthing agents to further improve their accumulation in the tumor tissue and, consequently, enhance their therapeutic effect. Herein, the advances attained in the application of inorganic nanoparticles in tumor targeting, imaging, photothermal therapy, and delivery of bioactive molecules, such as drugs (e.g., doxorubicin), genetic material (e.g., DNA, siRNA), and immunotherapy mediators are discussed as well as its limitations and toxicity issues.
- Study of the etiopathogenesis of Chronic Rhinosinusitis with Nasal Polyps: Focus on the host-environment interationPublication . Teles, Rafaela da Cruz Vieira Veloso; Farinha, Rosa Maria Barreiro da Cruz Ventura Roque; Buchwald, Christian vonIntroduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common disease, with high morbidity and chronicity, but its exact etiology is still unclear and remains a difficult to treat condition. Considering the emerging consensus that chronic rhinosinusitis (CRS) results from a dysfunctional host-environment interaction, this study pretends to clarify exogenous and endogenous factors, which can contribute to the occurrence and perpetuation of sinonasal mucosa inflammation observed in CRSwNP. The aims of this study are: 1) To evaluate endoscopic sinus surgery (ESS) efficacy in CRSwNP treatment and to establish prognostic factors for disease recurrence; 2) To compare the prevalence of nasal polyps (NP) in a group of workers with occupational dust exposure and in a control group; 3) To characterize systemic immunological alterations that occur in patients with CRSwNP compared to controls; 4) To clarify the role of food allergy in CRSwNP disease, comparing serum levels of food specific IgE and IgG antibodies in cases and controls. Material and Methods 1) Retrospective observational study in 85 patients with CRSwNP submitted to ESS and a minimum follow-up of 9 months. Patients’ demographics, occupational exposure, comorbidities, previous nasal surgeries, pre and postoperative symptoms and ENT examination findings, CT results, medical and surgical treatment information were collected from medical records. 2) Cross-sectional study with a random sample of textile (n=215) and retail store employees (n=101). Clinical data was gathered through a systematic interview, which included RhinoQOL-pv and CATTM questionnaires. A systematic endoscopic nasal examination was performed using a 0º rigid endoscope and Lund-Kennedy endoscopic score was determined for each participant. 3) Case-control study with 37 CRSwNP patients and 34 controls without CRS. Clinical data was gathered through a systematic interview. CT scan, skin prick test, spirometry, immunological parameters (leukocyte differential count, immunoglobulin classes and IgG subclasses) and 25-hydroxyvitamin D (25-HOD), alpha1-antitrypsin (A1AT) and C-reactive protein (CRP) dosage in serum specimens were obtained. 4) Case-control study with 33 patients with CRSwNP and 31 controls without CRS. Clinical data was gathered through a systematic interview (including the application of Food Frequency Questionnaire (QFA)). ELISA tests using OmegaDiagnostics® kit with 40 food allergens for detection of specific IgG antibodies were performed and food specific IgE antibodies were determined by immunoassay using ImmunoCAP™ against 11 food antigens. Statistical analysis was performed using SPSS v.23. Results 1) All rhinologic symptoms improved after ESS. The major and minor complications prevalences were 1.2% and 15.3%, respectively. Disease recurrence occurred in 31% of cases, but only 7% required surgical reintervention. Multivariate logistic regression analysis identified occupational dust exposure (p=0.001) and non-atopic asthma (p=0.012) as independent predictive variables in CRSwNP recurrence, unlike the other tested variables: age, sex, atopic asthma, allergic rhinitis, smoking habits, nasal polyps endoscopic grade, Lund-Mackay score and postoperative topical corticoid use. The adjusted logistic model had a ROC area under curve of 0.82 (p<0.001; CI95%: [0.73; 0.91]). 2) 316 participants were included in the study, i.e. 215 textile workers and 101 retail store workers. NP were found in 19 subjects (8.8%) among textile workers and none in the control group (p=0.001). The prevalence of NP increased by age strata (p=0.03) and by years of dust exposition (p=0.017). Polypoid degeneration of the middle turbinate was more prevalent in the exposed group (p=0.001) with Lund-Kennedy scoring also higher (p<0.001). RhinoQOL-pv and CATTM questionnaires had both significantly higher scores among textile employees. 3) A significantly higher eosinophil (p<0.001) and basophil relative count (p=0.022) and a lower relative neutrophil count (p=0.013) were found among CRSwNP group. Patients with CRSwNP had higher IgG1 (p=0.022), but lower IgG2 (p=0.014) and IgG3 (p=0.018) serum levels compared to controls. IgG4, total IgG, IgA, IgM and IgE serum levels did not differ between groups, as well as the prevalence of immunoglobulin classes or IgG subclasses deficiency; 25-HOD, A1AT and CRP dosage had also no significant difference. 4) The overall sum of food IgG antibodies was significantly lower in CRSwNP compared to control group (p=0.012), and this difference was also observed for different specific IgG antibodies (corn, soya, grain legumes, pear and apple, berries, citric fruit). In controls a positive correlation between IgG1 and the sum of food IgG antibodies was seen (p=0.049) but in CRSwNP group a negative correlation was found (p=0.048). Significant higher level of IgG1 was found among CRSwNP patients (p=0.041). Levels of serum specific IgE antibodies against the different studied food allergens, as well as the sum of food IgE antibodies, did not differ significantly between the groups. Conclusions Endoscopic sinus surgery proved to be an effective treatment in CRSwNP, but with a considerable disease recurrence. The first study of this investigation demonstrated that occupational dust exposure and non-atopic asthma are independent predictive factors of disease recurrence risk. The epidemiologic study performed, based on endoscopy, was pioneer in the evaluation of occupational exposure to dust impact on NP prevalence and the results pointed to an important association between them by demonstrating a significantly higher prevalence of the disease among textile workers. This investigation also showed a distinct systemic immunologic profile in CRSwNP patients compared to controls, and the variation observed in peripheral relative leukocyte count and the systemic IgG1 subclass shift are similar to what is known to happen in nasal polyp tissue. Concerning food allergy, it does not seem to have an important role in CRSwNP etiopathogenesis, whether if it is IgG or IgE-mediated. Moreover, the observed suppression of specific IgG antibodies against food allergens, its negative correlation with IgG1 and the raised IgG1 serum levels in CRSwNP, can be related to deviated IgG responses against other targets (e.g. airborne particles) and warrants future investigation.