Browsing by Issue Date, starting with "2025-07-07"
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- Assec Sim! – Sistemas de Informação e Multimédia, Lda.Publication . Alçada, João Ricardo Rodrigues; Almeida, Flávio Henrique deO estágio curricular realizado na Assec Sim! – Sistemas de Informação e Multimédia Lda., com início a 6 de novembro de 2023 e término a 10 de abril de 2024, consistiu numa etapa fundamental na aplicação dos conhecimentos adquiridos ao longo de oito anos de formação académica em Design Multimédia. Durante este período, a oportunidade de contactar diretamente com o mercado de trabalho permitiu-me compreender as exigências que são feitas aos profissionais deste setor. A integração numa equipa numerosa e diversificada como a da Assec, com reconhecimento tanto a nível nacional como internacional e com inúmeros prémios que comprovam os respetivos feitos, enriqueceu esta experiência. O ambiente corporativo, caracterizado por uma mistura saudável de experiência e inovação, foi ideal para a aplicação prática de habilidades técnicas e criativas. Os desafios propostos durante o estágio incluíram o desenvolvimento de conceitos de front-end para projetos interativos, com foco especial em Landing Pages, e a utilização de novas ferramentas de software como o Figma. Desde o planeamento até à fase de implementação, os projetos desenvolvidos foram acompanhados de constantes feedbacks e ajustes, proporcionando um ciclo de aprendizagem contínuo. Além das habilidades técnicas, o estágio reforçou a importância da comunicação e da capacidade de trabalhar em equipa. Em suma, o estágio na Assec Sim! não só permitiu a aplicação prática dos conhecimentos teóricos adquiridos como também impulsionou o desenvolvimento profissional no campo do Design Gráfico e Multimédia.
- A Interatividade Analógica no Design Editorial: Uma Exploração Prática no Universo da Revista ImpressaPublication . Carvalho, Cláudia Gonçalves; Ferreira, Joana Casteleiro Alves PitrezO presente relatório de projeto centra-se na investigação do conceito de interatividade no âmbito do design editorial impresso, com especial incidência sobre publicações periódicas, nomeadamente revistas. O principal objetivo consiste em compreender e explorar de que modo a interatividade — enquanto estratégia tradicionalmente associada ao universo digital — pode ser transposta e aplicada ao meio impresso, potenciando uma experiência de leitura mais rica, envolvente e sensorial. Partindo de uma reflexão crítica sobre o papel contemporâneo do design editorial, o estudo propõe-se analisar e explorar abordagens gráficas, estruturais e materiais que favoreçam formas de participação ativa do leitor, ampliando os limites da comunicação visual no suporte físico Para sustentar este propósito, o trabalho estrutura-se numa abordagem teóricoprática. Numa primeira fase, procede-se ao enquadramento conceptual do design editorial, abordando o papel do designer, a legibilidade, os conceitos de interação e interatividade, a influência das interfaces digitais e os componentes específicos das revistas. Numa segunda fase são analisados casos de estudo que ilustram práticas interativas no meio impresso e que dão origem a um mapa tipológico de estratégias interativas para revistas. Na terceira fase, desenvolve-se uma proposta gráfica: a reformulação da revista A Nossa Prima Vai à Madeira, incorporando elementos analógicos que estimulam a participação ativa do leitor. Conclui-se que a interatividade aplicada ao design editorial impresso constitui uma oportunidade para expandir os limites do meio e repensar a função comunicativa e expressiva do objeto editorial físico.
- Gestão do Capital Intelectual no setor da Construção CivilPublication . Sucena , André Filipe Calvário ; Nunes, António João Santos; Matos, Florinda Maria Carreira NetoIn a global economy that is constantly changing, academia and organizations face challenges that can be overcome independently. However, cooperation between universities and organizations can enhance their ability to overcome these challenges by increasing competitiveness, implementing new technology, and promoting innovation. The capacity to overcome these barriers can provide value in organisational, academic, and social contexts. With the aim of analyzing the impact of intellectual capital on the organisational performance (growth of the organization) of SMEs in the construction sector, this thesis will consist of five articles. These articles will highlight the importance of studying this issue in the construction sector and how knowledge management and strategic partnerships can influence the relationship between intellectual capital and organisational performance. The objective of the initial article was to examine the impact of intellectual capital on small and medium-sized enterprises (SMEs) in the construction industry. After reviewing the literature, it was determined that the most appropriate approach was to consider intellectual capital as a whole, which is divided into three categories: human capital, relational capital, and structural capital. Three interviews were conducted following the Matos (2013) model. The results indicate that intellectual capital significantly impacts the performance of SMEs in the construction sector. The evidence highlights the importance of knowledge management and strategic partnerships in this relationship. The objective of the second article was to confirm and expand upon the theoretical basis of the findings presented in the first article. After identifying a lack of literature on the subject within the construction sector, we broadened our search parameters and utilized the keywords 'intellectual capital', 'SME', 'company', and 'organisational performance', which yielded 105 articles. Two types of article analysis were conducted. First, we utilized VOSviewer to exclude articles that did not fit the theme. Then, we conducted a manual analysis, resulting in a total of 61 articles. After a thorough analysis, we identified four main clusters. Two of these clusters focused on intellectual capital and innovation, while the other two addressed knowledge management and strategic partnerships, as identified in the first article. This article presents a framework that will serve as the basis for the next two articles. The third article aims to analyze the relationship between organisational performance, intellectual capital, and strategic partnerships, similar to the previous article. The questionnaire answered by 88 companies analyzed the dimensions of partnership management, strategic relationship management, and identification of new partnerships. The article concludes that there is a strong relationship between three constructs: intellectual capital, strategic partnerships, and organisational performance. These constructs influence each other and have a joint influence on organisational performance. The language used is clear, objective, and value-neutral, and the text is free from grammatical errors, spelling mistakes, and punctuation errors. The content of the improved text is as close as possible to the source text, and no new aspects have been added. The fourth article employed a questionnaire to assess the applicability of the previously proposed framework in the context of SMEs in the construction sector. The questionnaire was administered to 88 entities, and the results indicated a significant correlation between knowledge management, intellectual capital, and organisational performance, with each factor influencing the others. The study found that the first two concepts individually influence the organisational performance of SMEs in the construction sector. However, when considered together, they have a greater impact on the latter concept. The article examines knowledge management in terms of knowledge storage, creation, and sharing. The framework is based on the first analysis of the field of study, the analysis of the theoretical basis, and two studies that confirmed the previously identified theoretical basis through a questionnaire. The fifth and final article presents a framework for companies, particularly in the construction sector, to analyze their environment and enhance their organisational performance. This research contributes to future research related to the topic under study and to the theoretical base.
- Evaluation of the Permeability of Brain Barriers to Compounds with Anticancer PropertiesPublication . Carreira, Maria Carolina Lareiro; Duarte, Ana Catarina Abreu; Santos, Cecília Reis Alves dosBrain tumors remain one of the most aggressive and lethal forms of cancer, posing significant challenges to treatment due to their critical location, infiltrative nature, and resistance to conventional therapies. One of the main factors limiting the effectiveness of treatment in brain tumors is the difficulty of chemotherapeutic agents reaching the central nervous system in adequate concentrations. Brain barriers, despite being essential for central nervous system protection and homeostasis, have a high selective nature that restricts the ability of chemotherapeutic agents to reach tumors, reducing the available therapeutic options. This restricted permeability is mostly mediated by the ABC transporter superfamily, which is expressed in both the blood-brain barrier and the blood–cerebrospinal fluid barrier and actively extrudes a wide variety of substances out of the brain, including many anticancer compounds. Taste receptors, traditionally associated with oral cavities, are also expressed in extraoral tissues, including the brain and many tumors. Lactisole, a well-known inhibitor of sweet taste receptors, affects cancer cell proliferation, possibly due to the high glucose dependency of these cells. Quercetin, a bitter compound that is a known ligand of TAS2R14, has demonstrated potential therapeutic effects by overcoming chemoresistance mechanisms and inducing apoptosis in cancer cells. This study aimed to investigate the permeability of the blood-brain and blood– cerebrospinal fluid barriers to lactisole and quercetin, and whether quercetin's interaction with TAS2R14 affects ABC transporter expression. For that a human choroid plexus papilloma cell line (HIBCPP) and a human cerebral microvascular endothelial cell line (hCMEC/D3) were used to establish in vitro models that mimics the in vivo phenotypic characteristics of the blood–cerebrospinal fluid barrier and the blood-brain barrier, respectively. It was verified that lactisole did not reduce viability in the HIBCPP cell line but in hCMEC/D3 cells, a decrease in viability was observed. Through transepithelial electrical resistance measurements and immunocytochemistry, it was possible to optimize the blood-brain barrier model. The 6th day of culture proved to be the most appropriate for the permeability assays, presenting the highest integrity of the cell monolayer and the highest levels of TAS2R14 expression. Additionally, RT-PCR was performed to confirm TAS2R14 expression in both cell lines. The permeability of the barriers to quercetin was not determined, due to completely degradation after 3 hours. Nevertheless, the expression levels of ABCC1 and ABCC4 were assessed in the blood–cerebrospinal fluid barrier cell line following TAS2R14 knockout and subsequent exposure to quercetin. However, no alterations in ABCC1 and ABCC4 expression in mock or TAS2R14 silenced conditions were detected. Lastly, lactisole permeability was assessed in the blood–cerebrospinal fluid barrier model, and a threefold higher concentration was observed in the apical compartment after 4 hours. Thus, it was concluded that lactisole crosses the blood–cerebrospinal fluid barrier in a timedependent manner.