ICI - Instituto Coordenador da Investigação
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O ICI integra Unidades de Investigação que exerçam as suas atividades na UBI e que tenham sido classificados com notação igual ou superior a Bom pelos painéis internacionais de avaliação periódica designados pela Fundação para a Ciência e Tecnologia.
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Browsing ICI - Instituto Coordenador da Investigação by Sustainable Development Goals (SDG) "03:Saúde de Qualidade"
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- ARIA-Italy managing allergic rhinitis and asthma in a changing world: The role of the PharmacistPublication . Paoletti, Giovanni; Giua, Corrado; Marti, Alessandro; Baio, Matteo Alberto; Valli, Nicolò; Ridolo, Erminia; Ventura, Maria Teresa; Passalacqua, Giovanni; Puggioni, Francesca; Lourenço, Olga ; Bousquet, Jean; Canonica, Giogio Walter; Heffler, Enrico; Lombardi, CarloAllergic rhinitis (AR) and asthma are common respiratory disorders that often occur together, affecting quality of life and increasing healthcare expenses of patients. These chronic illnesses are often managed without medical supervision, creating distinct challenges. A lack of resources can limit regular follow-up, which in turn promotes disease mismanagement and an increased reliance on self-medication, including the inappropriate use of corticosteroids and nasal decongestants. Community pharmacies could serve as critical primary healthcare providers, facilitating AR and asthma management by promoting therapy adherence, minimizing drug misuse, and improving symptom monitoring using digital tools. The evolving role of pharmacists as vital healthcare team members is highlighted by their involvement in screening, prevention, and patient education, particularly in underserved communities. Strengthening the partnerships between pharmacists, physicians, and patients may lead to more tailored and effective management strategies. This collaborative approach has demonstrated promise in enhancing disease outcomes and reducing healthcare costs.
- Driving Healthcare Monitoring with IoT and Wearable Devices: A Systematic ReviewPublication . João Pedro da Silva Baiense; Zdravevski, Eftim; Coelho, Paulo Jorge Simões; Serrano Pires, Ivan Miguel; Velez, Fernando J.Wearable technologies have become a significant part of the healthcare industry, collecting personal health data and extracting valuable information for real-time assistance. This review article analyzes 35 scientific publications on driving healthcare monitoring with IoT and wearable device applications. These articles were considered in a quantitative and qualitative analysis using the Natural Language Processing framework and the PRISMA methodology to filter the search results. The selected articles were published between January 2010 and May 2024 in one of the following scientific databases: IEEE Xplore, Springer, ScienceDirect (i.e., El- sevier), Association for Computing Machinery (ACM), Multidisciplinary Digital Publishing Institute (MDPI), or PubMed Central. The analysis considers population, methods, hardware, features, and communications. The research highlights that data collected from one or numerous sensors is processed and accessible in a database server for various uses, such as informing professional careers or assisting users. The review sug- gests that robust and efficient driving healthcare monitoring with IoT and wearable devices applications can be designed considering the valuable principles presented in this review.
- Insect-based chitin and chitosan from whole body sources and rearing by-products: extraction, physicochemical, structural and bioactivity characterisationPublication . Navarro, Pedro; Ribeiro, José Carlos Reis ; Luís, Ângelo Filipe Santos ; Domingues, Fernanda; Anjos, Ofélia; Cunha, LuisFractionation of edible insects and their rearing by-products can lead to expanded industrial applications and extraction of value-added products. The main goal of this study was to extract chitin and synthesise chitosan from three different insect sources – Tenebrio molitor larvae, adult Acheta domesticus and A. domesticus rearing by-products (legs and wings). Furthermore, the physicochemical, structural, and bioactive properties of insectderived chitin and chitosan were characterised and compared to commercial crustacean-based samples. Chitin was isolated from defatted sources through chemical hydrolysis followed by decolourisation and was deacetylated with a strong alkaline solution to synthesise chitosan. Notably, A. domesticus rearing by-products yielded the highest chitin and chitosan content. Chitin and chitosan derived from insects exhibited physicochemical and structural characteristics consistent with the α-polymorphic form, similar to the commercial samples. Differences were found in surface morphology, with insect-derived samples presenting large and irregular flakes and porosity, while the crustacean-derived samples presented irregularly arranged fibres and a more regular and smoother surface. As for antioxidant activity, although all chitosan samples demonstrated poor DPPH radical scavenging activity, this study showed for the first time that insect-derived chitosan presents lipid peroxidation inhibition ability. All chitosan samples presented antimicrobial activity against different pathogenic bacteria, with K. pneumoniae being the most susceptible strain. Nevertheless, there is potential for enhancement of the biological properties through modifications on the molecular weight and deacetylation degree. This research introduces the potential of cricketrearing by-products as sustainable sources of chitosan with functional bioactive properties.
- Quorum sensing inhibition evaluation method: An experiment-based microbiology laboratory coursePublication . Luís, Ângelo Filipe Santos ; Domingues, FernandaBacteria have developed a cell-to-cell communication system called quorum sensing (QS), allowing them to regulate group behavior and synchronize the expression of virulence factors, responsible for increasing their infection capacity and resistance to antimicrobials. Although the control of microbial infections through the inhibition of microbial growth has traditionally been the basis of antimicrobial chemotherapy, the emergence of antimicrobial resistance has led to the search for new microbial control strategies, namely through the inhibition of QS. Among the agents studied to inhibit this bacterial communication are essential oils (EO), which are considered very effective QS inhibitors. When searching for new QS inhibitor agents, it is essential to have a cheap and easy-to-perform method that allows the evaluation of this activity. Chromobacterium violaceum is a Gram-negative bacterium that has been widely used as a model organism in QS research laboratories because it produces the violet-colored pigment violacein, which is regulated by QS and is an easily observable and quantifiable characteristic marker. The objective of this work is to describe a method to evaluate the inhibition of the QS using Cymbopogon martinii EO as a potential inhibitory agent for violacein production by C. violaceum, which can be applied in the Microbiology laboratory course as a part of the programs of several science degrees. The proposed method is inexpensive and does not require specific equipment, enabling its easy implementation by the laboratory team and professors.
- Radio Coverage Assessment and Indoor Communication Enhancement in Hospitals: A Case Study at CHUCBPublication . da Silva, Óscar; Teixeira, Emanuel; Corceiro, Ana; Reis, António; Velez, Fernando J.The adoption of wireless medical technologies in hospital environments is often limited by cellular coverage issues, especially in indoor areas with complex structures. This study presents a detailed radio spectrum measurement campaign conducted at the Cova da Beira University Hospital Center (CHUCB), using the NARDA SRM-3006 and R&S®TSME6 equipment. The signal strength and quality of 5G NR, LTE, UMTS, and NB-IoT technologies were evaluated. Critical coverage gaps were identified, particularly at points 17, 19, and 21. Results revealed that operators MEO and NOS dominate coverage, with MEO providing better 5G NR coverage and NOS excelling in LTE signal quality. Based on the results, the localized installation of femtocells is proposed to improve coverage in these areas. The approach was designed to be scalable and replicable, with a planned application at Cumura Hospital (Guinea-Bissau), reinforcing the applicability of the solution in contexts with limited infrastructure. This work provides both technical and clinical contributions to achieving ubiquitous cellular coverage in healthcare settings.
- Smart textiles for health monitoring in industrial environments: a framework for wearable sensor integrationPublication . Vilarinho, Bruna Abreu; Vieira, Andre; Nunes-Pereira, João; Parente, João; Pires, Ivan Miguel Serrano ; Velez, Fernando J.The occupational health and safety of workers in industrial plants are increasingly compromised through exposure to thermal, physical, and psychological stressors. Wearable sensors embedded in garments have been introduced as a promising technology for real-time, continuous health monitoring without compromising workers' mobility or comfort. This paper reviews recent literature on wearable sensor technologies embedded in textiles, with a focus on their applicability in industrial settings. The paper identifies the key physiological parameters commonly monitored (e.g., heart rate, skin temperature, respiratory rate, and skin conductance), the materials and sensor types used, as well as the methods of integration into garments. Based on the findings, a conceptual model for a smart textile monitoring system tailored to industrial workers is proposed. The aim is to support the development of ergonomic, accessible, unobtrusive, and effective solutions that promote occupational health and prevent work-related illnesses.
- Wearable sensors for stress monitoring in meniscus injury rehabilitationPublication . Pires, Catarina de Sá Baio; Velez, Fernando J.; Coelho, Paulo Jorge Simões; Pataca, António Oseas; Pires, Ivan Miguel SerranoMonitoring vital signs is essential in identifying physiological stress, particularly in rehabilitating meniscus injuries. Stress can compromise the effectiveness of physiotherapy, affecting recovery. This paper reviews monitoring technologies, such as those that consider heart rate and sweating sensors, and their application in remote patient monitoring. It highlights the importance of collecting real-time data to personalize treatments and optimize recovery and explores the challenges and benefits of this approach. Integrating these technologies can significantly improve therapeutic results, prevent stress, and improve patients' quality of life.