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- p53 as the Focus of Gene Therapy: Past, Present and FuturePublication . Valente, Joana; Queiroz, João; Sousa, FaniSeveral gene deviations can be responsible for triggering oncogenic processes. However, mutations in tumour suppressor genes are usually more associated to malignant diseases, with p53 being one of the most affected and studied element. p53 is implicated in a number of known cellular functions, including DNA damage repair, cell cycle arrest in G1/S and G2/M and apoptosis, being an interesting target for cancer treatment.