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| 1.46 MB | Adobe PDF |
Advisor(s)
Abstract(s)
Several gene deviations can be responsible for triggering oncogenic processes. However, mutations in tumour suppressor genes are usually more associated to malignant diseases, with p53 being one of the most affected and studied element. p53 is implicated in a number of known cellular functions, including DNA damage repair, cell cycle arrest in G1/S and G2/M and apoptosis, being an interesting target for cancer treatment.
Description
Keywords
Antineoplastic Agents Combined Modality Therapy Genetic Therapy Genetic Vectors Humans Mutation Neoplasms Transfection Tumor Suppressor Protein p53
Citation
Publisher
Bentham Science Publishers