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p53 as the Focus of Gene Therapy: Past, Present and Future

2018Journal article Restricted access
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dc.contributor.authorValente, Joana
dc.contributor.authorQueiroz, João
dc.contributor.authorSousa, Fani
dc.date.accessioned2020-01-09T16:31:05Z
dc.date.available2020-01-09T16:31:05Z
dc.date.issued2018
dc.description.abstractSeveral gene deviations can be responsible for triggering oncogenic processes. However, mutations in tumour suppressor genes are usually more associated to malignant diseases, with p53 being one of the most affected and studied element. p53 is implicated in a number of known cellular functions, including DNA damage repair, cell cycle arrest in G1/S and G2/M and apoptosis, being an interesting target for cancer treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/1389450119666180115165447pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8178
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBentham Science Publisherspt_PT
dc.subjectAntineoplastic Agentspt_PT
dc.subjectCombined Modality Therapypt_PT
dc.subjectGenetic Therapypt_PT
dc.subjectGenetic Vectorspt_PT
dc.subjectHumanspt_PT
dc.subjectMutationpt_PT
dc.subjectNeoplasmspt_PT
dc.subjectTransfectionpt_PT
dc.subjectTumor Suppressor Protein p53pt_PT
dc.titlep53 as the Focus of Gene Therapy: Past, Present and Futurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1817pt_PT
oaire.citation.issue15pt_PT
oaire.citation.startPage1801pt_PT
oaire.citation.titleCurrent Drug Targetspt_PT
oaire.citation.volume19pt_PT
person.familyNameValente
person.familyNameQueiroz
person.familyNameSousa
person.givenNameJoana
person.givenNameJoão
person.givenNameFani
person.identifierVABrK9AAAAAJ
person.identifier.ciencia-id7515-7468-212D
person.identifier.ciencia-id931E-B66D-E341
person.identifier.ciencia-id991D-2E13-A840
person.identifier.orcid0000-0002-2408-9762
person.identifier.orcid0000-0002-3096-8325
person.identifier.orcid0000-0001-9996-2194
person.identifier.ridL-3104-2014
person.identifier.ridA-2014-2017
person.identifier.scopus-author-id7003705645
person.identifier.scopus-author-id7005110268
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd18cb0c2-0e40-40fe-a2dc-429c8a3ccb0b
relation.isAuthorOfPublicationc798c033-c160-4f99-a8ad-04416923943f
relation.isAuthorOfPublication2935de97-fc90-4d38-9505-4caa364f8a10
relation.isAuthorOfPublication.latestForDiscoveryc798c033-c160-4f99-a8ad-04416923943f

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