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- EUFOREA/EPOS2020 statement on the clinical considerations for CRSwNP carePublication . Hellings, Peter; Alobid, Isam; Anselmo‐Lima, Wilma T.; Bernal‐Sprekelsen, Manuel; Bjermer, Leif; Caulley, Lisa; Chaker, Adam; Constantinidis, Jannis; Conti, Lucio; De Corso, Eugenio; Desrosiers, Martin; Diamant, Zuzana; Gevaert, Philippe; Han, Jie; Heffler, Enrico; Hopkins, Claire; Landis, Basile; Lourenço, Olga; Lund, Valerie; Luong, Amber U.; Mullol, Joaquim; Peters, Anju; Philpott, Carl; Reitsma, Sietze; Ryan, Dermot; Scadding, Glenis; Senior, Brent; Tomazic, Peter Valentin; Toskala, Elina; Van Zele, Thibaut; Viskens, An‐Sofie; Wagenmann, Martin; Fokkens, WytskeFollowing the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) treatment algorithm for chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), patients suffering from severe uncontrolled CRSwNP are recommended to receive oral corticosteroids, (revision) sinus surgery, systemic biologicals and/or aspirin treatment after desensitization (ATAD). Given the major differences in indications, outcomes, practical considerations, risks and costs of these key pillars of treatment, there is a growing need to define criteria for each treatment option and list the clinically relevant and major considerations for them. This EUFOREA document therefore provides an expert panel overview of the expected outcomes, specific considerations and (contra)indications of the five major treatment arms of severe uncontrolled CRSwNP: oral corticosteroids, primary and revision sinus surgery, biological treatment and ATAD. This overview of treatment considerations is needed to allow physicians and patients to consider the different options in the context of providing optimal and personalized care for severe uncontrolled CRSwNP. In conclusion, the five major treatment options for severe uncontrolled CRSwNP have intrinsic advantages, specific indications and considerations that are of importance to the patient, the physician and the society. This EUFOREA statement supports the unmet need to define criteria for the indication of every treatment pillar of CRSwNP.
- Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesisPublication . Bousquet, Jean; Melén, Erik; Haahtela, Tari; Koppelman, Gerard; Togias, Alkis; Valenta, Rudolf; Akdis, Cezmi; Czarlewski, Wienczyslawa; Rothenberg, Marc; Valiulis, Arunas; Wickman, Magnus; Aberer, Werner; Heinrich, Joachim; Sisul, Juan; Nunes, Elizabete; Plavec, Davor; Agache, Ioana; Al-Ahmad, Mona; Serpa, Faradiba; Alobid, Isam; Kalayci, Omer; Vichyanond, Pakit; Giacco, S. Del; Fiocchi, Alessandro; Ansotegui Zubeldia, Ignacio Javier; Custovic, Adnan; Martins, Pedro Carreiro; Rouadi, Philip; Arshad, Syed Hasan; Asayag, Estrella; Bárbara, Cristina; Abdullah, Baharudin; Moniuszko, Marcin; Tomazic, Peter Valentin; Popov, T. A.; Sayah, Zineb; Lkhagvaa, Battur; Nyembue Tshipukane , Dieudonne; Thomas, Mike; Bennoor, Kazi Saifuddin; Fyhrquist, Nanna Theresia; Irani, Carla; Berghea, Elena Camelia; Ėmužytė, Regina; De Blay, Frédéric; Toppila-Salmi, Sanna Katriina; Bergmann, Karl-Christian; Bernstein, D.; Bewick, M.; Casale, Thomas; Scheire, Sophie; Bumbacea, Roxana Silvia; Cepeda Sarabia, Alfonso; Puggioni, Francesca; Bush, Andrew; Chandrasekharan, Ramanathan; Ohta, Ken; Okubo, Kimihiro; Charpin, Denis; Gomez, R Maximiliano; Chen, Y. Z.; O'Hehir, Robyn; Cherrez Ojeda, Ivan; Bedbrook, Anna; To, Teresa; Chu, Derek K; Devillier, Philippe; Schmid-Grendelmeier, Peter; Didier, Alain; Repka-Ramirez, María Susana; Teixeira, Maria Do Céu; Ispayeva, Zhanat; Dokic, Dejan; Quirce, Santiago; Douagui , Habib; Ivancevich, Juan Carlos; Viegi, Giovanni; Gotua, Maia; Todo-Bom, Ana; Blain, Hubert; Guzman, Maria Antonieta; Kalyoncu, Ali Fuat; Hagemann, Jan; Buhl, Roland; Hamamah, Samir; Caraballo, Luis; Jares, Edgardo; Wallace, Dana; Chivato, Tomás; Jartti, Tuomas; Jassem, Ewa; Christoff, George; Julge, Kalev; Ogulur, Ismail; Kardas, Przemyslaw; Doulaptsi, Maria; Kirenga, Bruce; Helga, Kraxner; Durham, Stephen; Kull, Inger; Kulus, Marek; Daniel, Aguilar; Shamji, Mohamed; Kuna, Piotr; Nadif, Rachel; La Grutta, Stefania; Brightling, Chris; Samoliński, Bolesław; Lau, Susanne; Wang, De Yun; Cordeiro, Carlos Manuel Da Silva Robalo; Solé, Dirceu; Le Thi Tuyet, Lan; Recto, Marysia; Ouedraogo, Solange; Halken, Susanne; Levin, Michael; Lipworth, Brian; Lourenço, Olga; Mahboub, Bassam; Vandenplas, O.; Niedoszytko, Marek; Sastre, Joaquin; Martinez‐Infante, E.; Kupczyk, Maciej; Torres, María Jose; Matricardi, Paolo Maria; Cecchi, Lorenzo; Celedón, Juan C; Miculinic, Neven; Roche, Nicolas; Just, Jocelyne; Migueres, Nicolas; Brussino, Luisa; Florin, Mihaltan; Olze, Heidi; Savouré, Marine; Nekam, Kristof; Pali, Isabella; Okamoto, Yoshitaka; Palomares, O.; Lemonnier, Nathanaël; Carlsen, Karin C. Lodrup; Palosuo, Kati; Soto-Martinez, Manuel; Panaitescu, Carmen; Kvedarienė, Violeta; Panzner, P.; Braido, Fulvio; Tsiligianni, Ioanna; Rodriguez-Gonzalez, Monica; Scichilone, Nicola; Canonica, Giogio Walter; Passalacqua, Giovanni; Romantowski, Jan; Urrutia-Pereira, Marilyn; Filho, Nelson Augusto Rosario; Ollert, Markus W.; Rottem, Menachem; Chkhartishvili, Ekaterine; Sova, Milan; Valovirta, Erkka; Mohammad, Yousser; Sperl, Annette; Williams, Siân; Spranger, Otto; Neffen, Hugo; Stelmach, Rafael; Burte, Emilie; Valentin Rostan, Marylin; Park, Hae-Sim; Van Ganse, Eric; Van Hage, Marianne; Pitsios, Constantinos; Vasankari, Tuula; Linnemann, Désirée Larenas; Loureiro, Cláudia Chaves; Sagara, Hironori; Worm, Margitta; Yiallouros, Panayiotis; Yusuf, Osman; Zaitoun, Fares; Bonini, Matteo; Hrubiško, Martin; Cingi, C.; Dykewicz, Mark; Zernotti, Mario; Calderon, Moises; Halpin, David M.G.; Zidarn, Mihaela; Patella, Vincenzo; Sheikh, Aziz; Zuberbier, Jaron; Papadopoulos, Nikolaos; Louis, Renaud; Suppli Ulrik, Charlotte; Fonseca, João P.; Zuberbier, Torsten; Anto, Josep M.; Costa, Elisio; Eiwegger, Thomas; Bosnic-Anticevich, Sinthia; Cruz, Alvaro; Sousa, Jaime Correia de; Louis-Philippe, Boulet; Erhola, Marina; Cardona, Victoria; Carr, Warner; Gemicioglu, Bilun; Pawankar, Ruby; Fokkens, Wytske; Calvo, Mário; Garcia-Aymerich, J.; Mäkelä, Mika J.; Hofmann, Maja Ann; Klimek, Ludger; Makris, Michael; Mohamed Sayed, Zeinab; Maurer, Marcus; D'Amato, G.; Momas, Isabelle; Siroux, Valérie; Almeida, Mário Morais; Corrigan, Chris; Mullol, Joaquim; Montefort, Stephen; Jutel, Marek; Pham Thi, Nhan; Hossny, Elham; Akdis, Mubeccel; Pfaar, Oliver; Ventura, Maria Teresa; Regateiro, Frederico S.; Bindslev-Jensen, Carsten; Ring, Johannes; Bustamante, Mariona; Pinto, Bernardo Sousa; Kaidashev, Igor; Guerra, Stefano; Standl, Marie; Sunyer, J.; Keil, Thomas; Barata, Luís Taborda; Camargos, Paulo; Weiss, Scott; Naclerio, Robert; Yorgancıoglu, Arzu; Zhang, Luo; Nadeau, Kari; Abdul Latiff, AmirAsthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.