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Efeito do treino de força no metaboloma do plasma de idosos com défice cognitivo
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| Documento em Acesso Embargado até dia 11-06-2028. Tente solicitar cópia ao autor carregando no ficheiro | 1.87 MB | Adobe PDF |
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Abstract(s)
O envelhecimento é um processo complexo associado a alterações metabólicas e ao
declínio cognitivo, exigindo intervenções eficazes capazes de promover um
envelhecimento saudável. Assim sendo o objetivo principal do presente trabalho foi
investigar o impacto de um programa de treino de força com a duração de 8 semanas no
metaboloma do plasma de idosos com défice cognitivo, utilizando espectroscopia de
ressonância magnética nuclear (RMN). Os participantes incluídos no estudo foram
divididos em três grupos: grupo controlo, grupo sujeito a treino de baixo volume (1 série
– grupo S1) e grupo sujeito a treino de alto volume (3 séries – grupo S3). Foram colhidas
amostras sanguíneas antes e após as 8 semanas de treino, que foram posteriormente
analisadas por RMN. As análises estatísticas multivariadas realizadas não evidenciaram
uma separação clara entre os grupos, após as 8 semanas de treino. No entanto, a análise
univariada revelou alterações estatisticamente significativas em alguns metabolitos
relacionados com o metabolismo energético e lipídico, em especial no grupo S1. Apesar
das limitações do estudo, os resultados sugerem que o treino de força pode induzir
alterações metabólicas importantes em idosos com défice cognitivo, podendo surgir
como uma estratégia não farmacológica para atenuar o impacto do envelhecimento e
melhorar a saúde geral de populações idosas com défice cognitivo. Estudo futuros
deverão ser realizados com maior número de amostra, em que fatores como a dieta,
medicação e atividade física sejam monitorizados, e avaliar os efeitos dos diferentes
volumes de treino de força a longo prazo, por um período superior a 8 semanas.
Aging is a complex process associated with metabolic changes and cognitive decline, requiring effective interventions capable of promoting healthy aging. Accordingly, the main objective of the present study was to investigate the impact of an 8-week strength training program on the plasma metabolome of older adults with cognitive impairment, using nuclear magnetic resonance (NMR) spectroscopy. Participants in the study were divided into three groups: a control group, a low-volume training group (1 set – S1 group), and a high-volume training group (3 sets – S3 group). Blood samples were collected before and after the 8-week training period and subsequently analyzed by NMR spectroscopy. Multivariate statistical analyses did not reveal a clear separation between the groups after the training period. However, univariate analysis identified statistically significant changes in some metabolites related to energy and lipid metabolism, particularly in the S1 group. Despite the study’s limitations, the results suggest that strength training may induce meaningful metabolic changes in older adults with cognitive impairment, potentially serving as a non-pharmacological strategy to mitigate the impact of aging and improve overall health in cognitively impaired elderly populations. Future studies should be conducted with larger sample sizes, in which factors such as diet, medication, and physical activity are monitored, and evaluate the effects of different volumes of strength training in the long term, for a period longer than 8 weeks.
Aging is a complex process associated with metabolic changes and cognitive decline, requiring effective interventions capable of promoting healthy aging. Accordingly, the main objective of the present study was to investigate the impact of an 8-week strength training program on the plasma metabolome of older adults with cognitive impairment, using nuclear magnetic resonance (NMR) spectroscopy. Participants in the study were divided into three groups: a control group, a low-volume training group (1 set – S1 group), and a high-volume training group (3 sets – S3 group). Blood samples were collected before and after the 8-week training period and subsequently analyzed by NMR spectroscopy. Multivariate statistical analyses did not reveal a clear separation between the groups after the training period. However, univariate analysis identified statistically significant changes in some metabolites related to energy and lipid metabolism, particularly in the S1 group. Despite the study’s limitations, the results suggest that strength training may induce meaningful metabolic changes in older adults with cognitive impairment, potentially serving as a non-pharmacological strategy to mitigate the impact of aging and improve overall health in cognitively impaired elderly populations. Future studies should be conducted with larger sample sizes, in which factors such as diet, medication, and physical activity are monitored, and evaluate the effects of different volumes of strength training in the long term, for a period longer than 8 weeks.
Description
Keywords
Défice cognitivo Envelhecimento Exercício físico Metabolómica Plasma Ressonância Magnética Nuclear Treino de força Aging Cognitive impairment