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Breast cancer targeted photothermal therapy mediated by hyaluronic acid functionalized reduced graphene oxide

2019-07-04Conference object Open access
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dc.contributor.authorSousa, Ana Rita Lima
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorAlves, Cátia Gomes
dc.contributor.authorCosta, Elisabete
dc.contributor.authorLouro, Ricardo
dc.contributor.authorMendonça, António G.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-01-09T15:27:46Z
dc.date.available2020-01-09T15:27:46Z
dc.date.issued2019-07-04
dc.description.abstractThe use of graphene-based nanomaterials in cancer photothermal therapy (PTT) is an emerging alternative to the currently available cancer treatments. In this regard, reduced graphene oxide (rGO) has been widely explored for cancer PTT due to its excellent photothermal capacity. However, rGO has some limitations, such as low colloidal stability and water insolubility, as well as absence of targeting capacity towards cancer cells. Herein, rGO produced by an environmentally- friendly method was functionalized with an amphiphilic polymer based on hyaluronic acid (HA-rGO) through hydrophobic-hydrophobic interactions for application in targeted breast cancer PTT. The functionalization improved rGO colloidal stability and cytocompatibility towards normal and breast cancer cells, as well as conferred targeting capacity towards CD44 overexpressing breast cancer cells. In addition, the photothermal effect mediated by HA-rGO upon laser irradiation reduced breast cancer cells’ viability. Overall, HA-rGO demonstrated a great potential for being used on-demand and selective treatment of breast cancer cells.pt_PT
dc.description.sponsorshipRita Lima-Sousa and Cátia G. Alves acknowledge funding from the grant UBI Santander/Totta.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8171
dc.language.isoengpt_PT
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBreast Cancerpt_PT
dc.subjectNear Infrared Lightpt_PT
dc.subjectPhotothermal Therapypt_PT
dc.subjectReduced Graphene Oxidept_PT
dc.titleBreast cancer targeted photothermal therapy mediated by hyaluronic acid functionalized reduced graphene oxidept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.conferencePlaceUBI, Covilhã, Portugalpt_PT
oaire.citation.titleCICS-UBI SYMPOSIUM 2019pt_PT
oaire.fundingStream5876
person.familyNameSousa
person.familyNameMiguel de Melo Diogo
person.familyNameAlves
person.familyNameda Rocha Costa
person.familyNameLouro
person.familyNameMendonça
person.familyNameJoaquim Sobreira Correia
person.givenNameAna Rita Lima
person.givenNameDuarte
person.givenNameCátia Gomes
person.givenNameElisabete Cristina
person.givenNameRicardo
person.givenNameAntónio
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0002-2392-6450
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id6603724134
person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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