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Advisor(s)
Abstract(s)
The use of graphene-based nanomaterials in cancer photothermal therapy (PTT) is an emerging
alternative to the currently available cancer treatments. In this regard, reduced graphene oxide
(rGO) has been widely explored for cancer PTT due to its excellent photothermal capacity.
However, rGO has some limitations, such as low colloidal stability and water insolubility, as well
as absence of targeting capacity towards cancer cells. Herein, rGO produced by an
environmentally- friendly method was functionalized with an amphiphilic polymer based on
hyaluronic acid (HA-rGO) through hydrophobic-hydrophobic interactions for application in
targeted breast cancer PTT. The functionalization improved rGO colloidal stability and
cytocompatibility towards normal and breast cancer cells, as well as conferred targeting capacity
towards CD44 overexpressing breast cancer cells. In addition, the photothermal effect mediated
by HA-rGO upon laser irradiation reduced breast cancer cells’ viability. Overall, HA-rGO
demonstrated a great potential for being used on-demand and selective treatment of breast cancer
cells.
Description
Keywords
Breast Cancer Near Infrared Light Photothermal Therapy Reduced Graphene Oxide