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Abstract(s)
Introdução: A Perturbação de Hiperatividade e Défice de Atenção é uma condição que
se manifesta através de dificuldades de atenção e concentração, problemas de
hiperatividade e impulsividade, que afetam negativamente a qualidade de vida. Apesar
de ser mais prevalente na população pediátrica, muitos adultos são também afetados. O
tratamento é feito com recurso a métodos farmacológicos e não farmacológicos, sendo
os fármacos mais eficazes até à data os psicoestimulantes. Havendo casos de intolerância,
abuso ou reações adversas associadas a estes, é importante haver fármacos alternativos
para o tratamento da PHDA, como os antidepressivos.
Objetivo: explorar a evidência científica existente referente a fármacos antidepressivos
para o tratamento e gestão de sintomas da PHDA no adulto de forma a oferecer mais
opções de tratamento e otimizar a terapêutica de adultos com esta perturbação.
Metodologia: A revisão seguiu as diretrizes PRISMA: Preferred Reporting Items for
Systematic Reviews e Meta-Analysis. Foi feita uma pesquisa na base de dados PubMed
através dos seguintes termos MeSH: “Attention Deficit Disorder with Hyperactivity/drug
therapy" AND "Antidepressive Agents”. Foi feita também uma pesquisa na base de dados
B-on com as palavras-chave “Adult ADHD” AND “Drug therapy” AND “antidepressants”.
Foram excluídos artigos em duplicado e artigos que não correspondiam à pesquisa.
Depois da leitura integral dos artigos resultantes para aplicação dos critérios de inclusão
e critérios de exclusão, restaram dois artigos.
Resultados: No geral, ambos os fármacos reduziram a gravidade dos sintomas
experienciados pelos participantes. No entanto, apenas a duloxetina (dose diária de
60mg) obteve resultados estatisticamente significativos, mostrando melhoria dos
sintomas da PHDA. As doses de 10mg e 20mg de vortioxetina não causaram diferença
estatisticamente significativa comparativamente ao placebo, exceto quando avaliado
pelo score SDS.
Conclusão: os estudos apresentados nesta revisão não são suficientes para provar a
eficácia da duloxetina e da vortioxetina para o tratamento da PHDA. Aconselha-se que
sejam feitos mais estudos sobre fármacos antidepressivos para o tratamento da PHDA,
com um número mais significativo de participantes e com maior duração, de modo a tirar
conclusões mais concretas.
Introduction: Attention Deficit and Hyperactivity Disorder is a condition that manifests itself through attention and concentration difficulties, hyperactivity, and impulsivity problems, which negatively affect the quality of life. Despite being more prevalent in the pediatric population, many adults are also affected by it. Treatment is carried out using pharmacological and non-pharmacological methods, with the most effective drugs to date being psychostimulants. As there are cases of intolerance, abuse, or adverse reactions associated with these, it is important to have alternative medications for the treatment of ADHD, such as antidepressants. Objective: to explore the existing scientific evidence regarding antidepressant drugs for the treatment and management of ADHD symptoms in adults in order to offer more treatment options and optimize therapy for adults with this disorder. Methodology: The review followed the PRISMA guidelines: Preferred Reporting Items for Systematic Reviews and Meta-Analysis. A search was performed in the PubMed database using the following MeSH terms: “Attention Deficit Disorder with Hyperactivity/drug therapy” AND “Antidepressive Agents”. A search was also performed on the B-on database with the keywords “Adult ADHD” AND “Drug therapy” AND “antidepressants”. Duplicate articles and articles that did not correspond to the search were excluded. After reading the resulting articles in full to apply the inclusion and exclusion criteria, two articles remained. Results: Overall, both drugs reduced the severity of symptoms experienced by the participants. However, only duloxetine (a daily dose of 60mg) obtained statistically significant results, showing improvement in ADHD symptoms. The 10mg and 20mg doses of vortioxetine did not cause a statistically significant difference compared to placebo, except when evaluated by the SDS score. Conclusion: the studies presented in this review are not sufficient to prove the efficacy of duloxetine and vortioxetine for the treatment of ADHD. It is advised that more studies be carried out on antidepressant drugs for the treatment of ADHD, with a more significant number of participants and with a longer duration, in order to draw more concrete conclusions.
Introduction: Attention Deficit and Hyperactivity Disorder is a condition that manifests itself through attention and concentration difficulties, hyperactivity, and impulsivity problems, which negatively affect the quality of life. Despite being more prevalent in the pediatric population, many adults are also affected by it. Treatment is carried out using pharmacological and non-pharmacological methods, with the most effective drugs to date being psychostimulants. As there are cases of intolerance, abuse, or adverse reactions associated with these, it is important to have alternative medications for the treatment of ADHD, such as antidepressants. Objective: to explore the existing scientific evidence regarding antidepressant drugs for the treatment and management of ADHD symptoms in adults in order to offer more treatment options and optimize therapy for adults with this disorder. Methodology: The review followed the PRISMA guidelines: Preferred Reporting Items for Systematic Reviews and Meta-Analysis. A search was performed in the PubMed database using the following MeSH terms: “Attention Deficit Disorder with Hyperactivity/drug therapy” AND “Antidepressive Agents”. A search was also performed on the B-on database with the keywords “Adult ADHD” AND “Drug therapy” AND “antidepressants”. Duplicate articles and articles that did not correspond to the search were excluded. After reading the resulting articles in full to apply the inclusion and exclusion criteria, two articles remained. Results: Overall, both drugs reduced the severity of symptoms experienced by the participants. However, only duloxetine (a daily dose of 60mg) obtained statistically significant results, showing improvement in ADHD symptoms. The 10mg and 20mg doses of vortioxetine did not cause a statistically significant difference compared to placebo, except when evaluated by the SDS score. Conclusion: the studies presented in this review are not sufficient to prove the efficacy of duloxetine and vortioxetine for the treatment of ADHD. It is advised that more studies be carried out on antidepressant drugs for the treatment of ADHD, with a more significant number of participants and with a longer duration, in order to draw more concrete conclusions.
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Keywords
Adulto Antidepressivos Phda Tratamento