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Abstract(s)
O cobre é um oligoelemento essencial para muitas funções fisiológicas.
Existem mecanismos homeostáticos que permitem que este actue como cofactor
em processos enzimáticos e que previnem a acumulação de cobre em
níveis tóxicos. Esta dissertação tem como objectivo primordial compreender
o papel biológico do cobre na fisiologia humana. A importância do cobre é
justificada pelo seu papel na transferência de electrões nas actividades
enzimáticas de oxidação-redução, fisiologicamente importantes. Destaca-se
o envolvimento do cobre na defesa contra o dano oxidativo e, ao mesmo
tempo, a sua capacidade para formar radicais hidroxil, através da reacção de
Fenton. Nesta dissertação procurou-se avaliar as necessidades nutricionais
diárias de cobre, com exposição das DDRs recomendas, da
biodisponibilidade e do metabolismo do cobre. Incidiu-se sobre as
consequências da deficiência bem como do excesso de cobre. Foi também
focada a existência de erros genéticos do metabolismo do cobre. Para tal,
organizou-se uma revisão da literatura publicada sobre a temática,
utilizando a base de dados MEDLINE. A principal conclusão é que, apesar
de ser necessária a reavaliação dos dados publicados e a realização de novas
investigações, o cobre é um elemento Vital para a Saúde Humana.
Copper is an essential trace element for many physiological functions. Homeostatic mechanisms exist to allow copper to act as a cofactor in enzymatic processes and to prevent the accumulation of copper in toxic levels. The primary objective of this thesis is understand the copper biological role in human physiology. Copper importance is justified by its role in the electrons transfer in the enzymatic oxidation-reduction activities, physiologically importants. It was here presented the copper involvement in defence against oxidative damage and at the same time, their ability to form hydroxyl radical by the Fenton reaction. In this dissertation it was evaluated the daily nutritional copper needs, with exposure of recommended DDRs, bioavailability and copper metabolism. It was focused the consequences of copper deficiency and copper excess, and the existence of genetic errors of copper metabolism. To this end, it was organized a review of published literature on this thematic, using the database MEDLINE. The main conclusion is that, although it is required a re-assessment of the published data and new researchs, copper is a Vital element to Human Health.
Copper is an essential trace element for many physiological functions. Homeostatic mechanisms exist to allow copper to act as a cofactor in enzymatic processes and to prevent the accumulation of copper in toxic levels. The primary objective of this thesis is understand the copper biological role in human physiology. Copper importance is justified by its role in the electrons transfer in the enzymatic oxidation-reduction activities, physiologically importants. It was here presented the copper involvement in defence against oxidative damage and at the same time, their ability to form hydroxyl radical by the Fenton reaction. In this dissertation it was evaluated the daily nutritional copper needs, with exposure of recommended DDRs, bioavailability and copper metabolism. It was focused the consequences of copper deficiency and copper excess, and the existence of genetic errors of copper metabolism. To this end, it was organized a review of published literature on this thematic, using the database MEDLINE. The main conclusion is that, although it is required a re-assessment of the published data and new researchs, copper is a Vital element to Human Health.
Description
Keywords
Cobre Cobre - Aspectos biológicos Cobre - Aspectos nutricionais Metabolismo do cobre Doença de Menkes Doença de Wilson Saúde humana - Cobre
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Citation
Publisher
Universidade da Beira Interior