Loading...
Publication
Comorbilidades em pacientes com Síndrome de Sjögren
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 565.47 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Introdução: A Síndrome de Sjögren (SS) primária é uma doença autoimune sistémica
caracterizada por infiltração linfocítica nas glândulas exócrinas, resultando em
manifestações clássicas de secura ocular e oral, além de uma ampla gama de
comorbilidades que afetam diversos sistemas orgânicos. Essa condição apresenta uma
prevalência notória, sobretudo entre mulheres, e o seu diagnóstico tardio
frequentemente associa-se a complicações que comprometem significativamente a
qualidade de vida dos pacientes.
Objetivos: Avaliar a prevalência e a relação entre a expressão clínica da SS primária e
um conjunto de comorbilidades em 47 pacientes acompanhados na consulta de
Reumatologia da Unidade Local de Saúde de Castelo Branco (ULSCB). Pretende-se,
assim, aprofundar o entendimento sobre os padrões clínicos e os fatores preditivos que
influenciam o prognóstico desses pacientes, contribuindo para o desenvolvimento de
estratégias terapêuticas personalizadas.
Métodos: Estudo observacional, transversal e retrospetivo, com análise de dados
clínicos, laboratoriais, demográficos e terapêuticos extraídos dos registos médicos dos
participantes. Foram aplicadas ferramentas como o Índice de Atividade da Doença
(ESSDAI) e o Newcastle Sjögren’s Stratification Tool (NSST) para a estratificação dos
pacientes, permitindo uma avaliação detalhada das manifestações e comorbilidades
associadas à SS primária.
Resultados: Os resultados demonstraram uma elevada prevalência de
comorbilidades, destacando-se a dislipidemia (48,94%), hipertensão arterial (46,81%),
obesidade (38,30%), depressão (27,66%) e fibromialgia (23,40%). Adicionalmente, o
estudo identificou a presença de outras condições relevantes, como doenças
autoimunes secundárias, distúrbios hematológicos e complicações cardiovasculares, de
forma a evidenciar a complexidade da SS primária e a necessidade de um
acompanhamento multidisciplinar.
Conclusão: Em conclusão, os achados reforçam que a SS primária é uma doença
multifacetada que procura uma abordagem terapêutica personalizada e um seguimento
clínico integrado, envolvendo diversas especialidades médicas. A implementação de
protocolos de rastreio precoce e intervenções direcionadas poderá não apenas melhorar
o prognóstico, mas também otimizar a qualidade de vida dos pacientes, enfatizando a importância de investigações futuras para aprofundar os mecanismos subjacentes à
interação entre a SS primária e suas comorbilidades.
Introduction: Primary Sjögren's Syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration in the exocrine glands, resulting in classic manifestations of ocular and oral dryness, in addition to a wide range of comorbidities that affect several organ systems. This condition has a notorious prevalence, especially among women, and its late diagnosis is often associated with complications that significantly compromise the quality of life of patients. Objectives: Evaluate the prevalence and relationship between the clinical expression of primary SS and a set of comorbidities in 47 patients followed up at the Rheumatology consultation of the Local Health Unit of Castelo Branco (ULSCB). It is intended, therefore, to deepen the understanding of the clinical patterns and predictive factors that influence the prognosis of these patients, contributing to the development of personalized therapeutic strategies. Methods: Observational, cross-sectional and retrospective study, with analysis of clinical, laboratory, demographic and therapeutic data extracted from the participants' medical records. Tools such as the Disease Activity Index (ESSDAI) and the Newcastle Sjögren’s Stratification Tool (NSST) were applied to stratify patients, allowing a detailed assessment of the manifestations and comorbidities associated with primary SS. Results: The results showed a high prevalence of comorbidities, especially hypertension (46.81%), dyslipidemia (48.94%), obesity (38.30%), fibromyalgia (23.40%) and depression (27.66%). In addition, the study identified the presence of other relevant conditions, such as secondary autoimmune diseases, hematological disorders, and cardiovascular complications, in order to highlight the complexity of primary SS and the need for multidisciplinary follow-up. Conclusion: In conclusion, the findings reinforce that primary SS is a multifaceted disease that seeks a personalized therapeutic approach and an integrated clinical follow-up, involving several medical specialties. The implementation of early screening protocols and targeted interventions may not only improve the prognosis, but also optimize the quality of life of patients, emphasizing the importance of future investigations to deepen the mechanisms underlying the interaction between primary SS and its comorbidities.
Introduction: Primary Sjögren's Syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration in the exocrine glands, resulting in classic manifestations of ocular and oral dryness, in addition to a wide range of comorbidities that affect several organ systems. This condition has a notorious prevalence, especially among women, and its late diagnosis is often associated with complications that significantly compromise the quality of life of patients. Objectives: Evaluate the prevalence and relationship between the clinical expression of primary SS and a set of comorbidities in 47 patients followed up at the Rheumatology consultation of the Local Health Unit of Castelo Branco (ULSCB). It is intended, therefore, to deepen the understanding of the clinical patterns and predictive factors that influence the prognosis of these patients, contributing to the development of personalized therapeutic strategies. Methods: Observational, cross-sectional and retrospective study, with analysis of clinical, laboratory, demographic and therapeutic data extracted from the participants' medical records. Tools such as the Disease Activity Index (ESSDAI) and the Newcastle Sjögren’s Stratification Tool (NSST) were applied to stratify patients, allowing a detailed assessment of the manifestations and comorbidities associated with primary SS. Results: The results showed a high prevalence of comorbidities, especially hypertension (46.81%), dyslipidemia (48.94%), obesity (38.30%), fibromyalgia (23.40%) and depression (27.66%). In addition, the study identified the presence of other relevant conditions, such as secondary autoimmune diseases, hematological disorders, and cardiovascular complications, in order to highlight the complexity of primary SS and the need for multidisciplinary follow-up. Conclusion: In conclusion, the findings reinforce that primary SS is a multifaceted disease that seeks a personalized therapeutic approach and an integrated clinical follow-up, involving several medical specialties. The implementation of early screening protocols and targeted interventions may not only improve the prognosis, but also optimize the quality of life of patients, emphasizing the importance of future investigations to deepen the mechanisms underlying the interaction between primary SS and its comorbidities.
Description
Keywords
Comorbilidades Dor Síndrome de Sjögren