| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 452.83 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Introdução: A endometriose, definida como a presença de tecido endometrial fora do útero, é uma das doenças ginecológicas inflamatórias mais comuns, afetando cerca de dez por cento das mulheres em idade reprodutiva, sendo uma das principais causas de infertilidade feminina. O intervalo médio entre o aparecimento dos primeiros sintomas e o diagnóstico da doença foi reportado como sendo entre sete a dez anos. Atualmente, o gold-standard no diagnóstico da endometriose é a laparoscopia, um procedimento minimamente invasivo com potenciais riscos, existindo a necessidade de um método não-invasivo que contribua para a redução do tempo entre o início dos sintomas e o diagnóstico definitivo da doença. Existe, assim, uma rápida expansão da literatura no que concerne ao uso de métodos de imagem e de biomarcadores moleculares, tanto a nível do plasma, do fluído peritoneal, da urina ou mesmo do tecido endometrial na pesquisa da endometriose.
Objetivos: 1- Identificar a importância do diagnóstico precoce da endometriose; 2- Identificar os métodos atualmente usados para o diagnóstico definitivo da endometriose; 3- Avaliar a eficácia de novos métodos no diagnóstico da endometriose; 4- Comparar os benefícios e as limitações das técnicas atualmente empregues com os diferentes métodos não-invasivos estudados.
Materiais e métodos: Para a realização desta dissertação foi realizada uma pesquisa alargada de literatura científica, que decorreu desde dezembro de 2015 a novembro de 2016, acerca do diagnóstico da endometriose em bases de dados, como Pubmed, ResearchGate e B-on, sendo utilizadas como principais palavras-chave: “endometriosis”; “endometriosis diagnosis”; “non-invasive diagnosis of endometriosis”; “endometriosis biomarkers”.
Introduction: Endometriosis, defined as the presence and growth of endometrial tissue outsider of the uterus, is one of the most common inflammatory gynaecological conditions, affecting up to ten percent of women in reproductive age, being one of the major causes of female infertility. The median time between onset of symptoms and diagnosis has been reported as anywhere from seven to ten years. The current gold-standard test for endometriosis is laparoscopy, a minimally invasive procedure with potential risks. This accentuates the need of a non-invasive test that can reduce the timespan between onset of symptoms and diagnosis of endometriosis. In that sense, there has been a rapid expansion of literature concerning the use of imaging techniques or molecular biomarkers found in the plasma, peritoneal fluid, urine or even in endometrial tissue. Objectives: 1- Establish the importance of an early diagnosis of endometriosis; 2- Identify the current methods used for the diagnosis of endometriosis; 3 – Assess the efficacy of new diagnostic methods for endometriosis; 4- Compare the benefits and limitations of the diagnostic procedures currently employed against those in study. Materials and Methods: For the completion of this dissertation, a broad research of scientific literature was underwent, from December 2015 to November 2016, concerning the diagnosis of endometriosis on databases such as Pubmed, ResearchGate and B-on, using the following terms as keywords: “endometriosis”; “endometriosis diagnosis”; “non-invasive diagnosis of endometriosis”; “endometriosis biomarkers”.
Introduction: Endometriosis, defined as the presence and growth of endometrial tissue outsider of the uterus, is one of the most common inflammatory gynaecological conditions, affecting up to ten percent of women in reproductive age, being one of the major causes of female infertility. The median time between onset of symptoms and diagnosis has been reported as anywhere from seven to ten years. The current gold-standard test for endometriosis is laparoscopy, a minimally invasive procedure with potential risks. This accentuates the need of a non-invasive test that can reduce the timespan between onset of symptoms and diagnosis of endometriosis. In that sense, there has been a rapid expansion of literature concerning the use of imaging techniques or molecular biomarkers found in the plasma, peritoneal fluid, urine or even in endometrial tissue. Objectives: 1- Establish the importance of an early diagnosis of endometriosis; 2- Identify the current methods used for the diagnosis of endometriosis; 3 – Assess the efficacy of new diagnostic methods for endometriosis; 4- Compare the benefits and limitations of the diagnostic procedures currently employed against those in study. Materials and Methods: For the completion of this dissertation, a broad research of scientific literature was underwent, from December 2015 to November 2016, concerning the diagnosis of endometriosis on databases such as Pubmed, ResearchGate and B-on, using the following terms as keywords: “endometriosis”; “endometriosis diagnosis”; “non-invasive diagnosis of endometriosis”; “endometriosis biomarkers”.
Description
Keywords
Biomarcadores Diagnóstico Diagnóstico Não-Invasivo Endometriose Gold-Standard Novos Métodos