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Authors
Abstract(s)
Existe um conjunto de doenças que se assemelham entre si pelo facto de apresentarem danos em órgãos e tecidos que decorrem de respostas a antigénios do próprio.
A essas doenças dĂĄ-se o nome de doenças auto-imunes. Estas apresentam uma prevalĂȘncia e
incidĂȘncia distintas entre si, sendo superiores no sexo feminino e aumentando com o decorrer
da idade. Existem autoanticorpos que são mais prevalentes em certas doenças auto-imunes,
no entanto, nem todos podem predizer com exactidĂŁo a ocorrĂȘncia de doença. Apesar disso,
tem-se conhecimento que existem autoanticorpos que se encontram no soro de doentes até
10 anos antes do inĂcio do aparecimento da doença.
Este estudo pretendeu avaliar a prevalĂȘncia dos anticorpos anti-Saccharomyces
cerevisiae, os anticorpos anti-mitocondriais, os anticorpos anti-nucleares, os anticorpos antifosfolĂpidos,
anticorpos anti-pĂ©ptidos cĂclicos citrulinados, factor reumatĂłide, anticorpos antigliadina
e anticorpos anti-transglutaminase tecidular. Para isso, foram executados métodos
de anålise e métodos de confirmação, tendo-se contabilizado como apresentando
autoanticorpos apenas os dadores que apresentaram positividade nos métodos confirmatórios.
Obteve-se uma prevalĂȘncia de autoanticorpos no total da população de 12,54%,o que
estĂĄ dentro dos valores encontrados na bibliografia. Os resultados obtidos revelam uma maior
prevalĂȘncia de autoanticorpos em dadores do sexo feminino e um aumento da prevalĂȘncia de
autoanticorpos no decorrer da idade. Para a totalidade dos dadores os autoanticorpos mais
prevalentes foram os anticorpos anti-Saccharomyces cerevisiae (IgA e IgG) seguidos do factor
reumatĂłide, tendo-se obtido os mesmos resultados quando se analisam apenas os dadores
masculinos. A prevalĂȘncia nos dadores femininos foi distinta, apresentando como
autoanticorpos mais prevalentes os anticorpos anti-Saccharomyces cerevisiae (IgA e IgG),
seguindo-se os anticorpos anti-fosfolĂpidos.
Verifica-se a necessidade de se fazerem estudos e exames complementares de modo a
confirmar os resultados obtidos neste trabalho.
Autoimmune diseases are a very similar group of diseases presenting injuries on organs and tissues which come from overactive immune response to its own antigens.. They have a very different prevalence and incidence, being higher on females and increasing with age. There are some autoantibodies prevalent in certain autoimmune diseases, although, not all can predict with precision the emergency of the disease. Even so there is the knowledge that some auto antibodies are in the serum of patients until 10 years before the appearance of the disease. The aim of this study was to evaluate the prevalence of antibodies anti- Saccharomyces cerevisiae, the anti-mitochondrial antibodies, anti-nuclear antibodies, antiphospholipids antibodies, anti-cyclic citrullinated peptids antibodies, rheumatoid factor , anti-gliadin antibodies and anti-tissue transglutamine. Only donors who tested positive in the confirmation test for autoantibodies were recorded in the study. Was found a prevalence of 12,54% in the total population with autoantibodies, being within the values of bibliography. The results obtained reveal a higher prevalence of autoantibodies in female donors and an increase of autoantibodies with aging. For all the donors the most prevalent autoantibodies were the anti Saccharomyces cerevisiae antibodies (IgA and IgG) followed by the rheumatoid factor, having been obtained the same results when considering only male donors. The prevalence in female donors was distinct, showing as most prevalent autoantibodies the anti-Saccharomyces cerevisiae antibodies (IgA and IgG) followed by the anti-phospholipids antibodies. Itâs necessary to make more studies and laboratory tests to confirm the results obtained in this study.
Autoimmune diseases are a very similar group of diseases presenting injuries on organs and tissues which come from overactive immune response to its own antigens.. They have a very different prevalence and incidence, being higher on females and increasing with age. There are some autoantibodies prevalent in certain autoimmune diseases, although, not all can predict with precision the emergency of the disease. Even so there is the knowledge that some auto antibodies are in the serum of patients until 10 years before the appearance of the disease. The aim of this study was to evaluate the prevalence of antibodies anti- Saccharomyces cerevisiae, the anti-mitochondrial antibodies, anti-nuclear antibodies, antiphospholipids antibodies, anti-cyclic citrullinated peptids antibodies, rheumatoid factor , anti-gliadin antibodies and anti-tissue transglutamine. Only donors who tested positive in the confirmation test for autoantibodies were recorded in the study. Was found a prevalence of 12,54% in the total population with autoantibodies, being within the values of bibliography. The results obtained reveal a higher prevalence of autoantibodies in female donors and an increase of autoantibodies with aging. For all the donors the most prevalent autoantibodies were the anti Saccharomyces cerevisiae antibodies (IgA and IgG) followed by the rheumatoid factor, having been obtained the same results when considering only male donors. The prevalence in female donors was distinct, showing as most prevalent autoantibodies the anti-Saccharomyces cerevisiae antibodies (IgA and IgG) followed by the anti-phospholipids antibodies. Itâs necessary to make more studies and laboratory tests to confirm the results obtained in this study.
Description
Keywords
Doenças auto-imunes Doenças auto-imunes - Anticorpos Autoanticorpos preditivos Dadores de sangue portugueses - Anticorpos