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Advisor(s)
Abstract(s)
Introdução: Evidências recentes têm demonstrado que as repercussões da obesidade a
nível clínico são mais extensas do que se pensava anteriormente, sendo esta condição
responsável por promover no nosso corpo um aumento dos parâmetros inflamatórios,
levando não só à proliferação de mais tecido adiposo, mas também ao surgimento de
outro tipo de patologia metabólica, como por exemplo aumento dos níveis de insulinoresistência. Sabemos também que a prevalência de obesidade e diabetes mellitus,
simultaneamente, tem aumentado de forma significativa.
Objetivo:Identificar se existe relação entre as células inflamatórias típicas da obesidade
presentes no tecido adiposo subcutâneo abdominal e os níveis de insulino-resistência
dos indivíduos em estudo.
Metodologia: Subanálise de um estudo prospetivo e randomizado, baseada no
protocolo já previamente aprovado para o mesmo. Realizou-se um estudo observacional,
unicêntrico, transversal, através da consulta da base de dados previamente construída
para o projeto acima descrito. Foram avaliados 36 doentes, seguidos em consulta de
Hipertensão Arterial/Nefrologia no Hospital Amato Lusitano, que apresentavam
simultaneamente o diagnóstico de hipertensão arterial/obesidade ou hipertensão
arterial/síndrome metabólica. Estes doentes foram estudados de acordo com os
resultados da sua biópsia ao tecido adiposo abdominal subcutâneo (através da contagem
de macrófagos perivasculares e macrófagos totais), índice de insulino-resistência
(através de hemoglobina glicosilada sanguínea e índice de adiposidade visceral), valores
sanguíneos de vitamina D, linfócitos T, colesterol não-HDL, colesterol total e
triglicéridos, perímetro abdominal e índice de massa corporal. Utilizou-se o software
SPSSv17.0 para a análise estatística dos dados.
Resultados: Observou-se uma correlação inversa moderada entre vitamina D e
macrófagos perivasculares (r=-0.387; p=0.024). Foi também verificada uma associação
positiva moderada entre macrófagos perivasculares e os triglicéridos sanguíneos
(r=0.429; p=0.011), assim como entre o colesterol total e linfócitos T (r=0.375;
p=0.026).
Conclusão: Existe aumento dos parâmetros inflamatórios considerados (macrófagos
perivasculares e linfócitos T) síncrono com o aumento dos valores que permitiam caracterizar a síndrome metabólica de cada doente (triglicéridos e colesterol total),
respetivamente. Foi também encontrada uma correlação inversa entre a vitamina D e
macrófagos perivasculares, ambos utilizados para quantificar o nível de inflamação basal
dos indivíduos. Serão necessários estudos adicionais para caracterizar mais
pormenorizadamente a relação entre estas variáveis.
Introduction: Recent evidence has shown that the clinical repercussions of obesity are more extensive than previously thought, and this condition is responsible for promoting a raise in inflammatory markers in our bodies. This leads not only to the proliferation of more adipose tissue, but also to the appearance of another metabolic pathologies, such as increased levels of insulin resistance. We also know that the prevalence of obesity and diabetes mellitus, simultaneously, is growing exponentially. Objective: Identify whether there is a relationship between typical obesity related inflammatory cells present in abdominal subcutaneous adipose tissue and the insulin resistance levels of the individuals under study. Methodology: Subanalysis of a prospective and randomized study, based on the protocol previously approved for it. An observational, single-center, cross-sectional study carried out by consulting the database previously built for the project described above. Thirty-six patients were chosen from the pool of patients followed in hypertension/nephrology consultations at Hospital Amato Lusitano, who simultaneously had the diagnosis of hypertension/obesity or hypertension/metabolic syndrome. These patients were studied according to the results of their biopsy of subcutaneous abdominal adipose tissue (through the percentage of perivascular macrophages and total macrophages), insulin resistance index (through blood glycated hemoglobin and visceral adiposity index), blood values of vitamin D, T lymphocytes, non-HDL cholesterol, total cholesterol and triglycerides, abdominal perimeter and body mass index. The SPSSv17.0 software was used for the statistical analysis of the data. Results: There was a moderate inverse correlation between vitamin D and perivascular macrophages (r=-0.387; p=0.024). There was also a moderate positive association between perivascular macrophages and blood triglycerides (r=0.429; p=0.011), as well as between total cholesterol and T lymphocytes (r=0.375; p=0.026). Conclusion: The increase in the inflammatory parameters (perivascular macrophages and T lymphocytes) is synchronous with the increase in values that allowed the characterization of the metabolic syndrome of each patient (triglycerides and total cholesterol), respectively. An inverse correlation was also found between vitamin D and perivascular macrophages, both used to quantify the individuals' baseline inflammation level. Additional studies will be needed to further characterize the relationship between these variables.
Introduction: Recent evidence has shown that the clinical repercussions of obesity are more extensive than previously thought, and this condition is responsible for promoting a raise in inflammatory markers in our bodies. This leads not only to the proliferation of more adipose tissue, but also to the appearance of another metabolic pathologies, such as increased levels of insulin resistance. We also know that the prevalence of obesity and diabetes mellitus, simultaneously, is growing exponentially. Objective: Identify whether there is a relationship between typical obesity related inflammatory cells present in abdominal subcutaneous adipose tissue and the insulin resistance levels of the individuals under study. Methodology: Subanalysis of a prospective and randomized study, based on the protocol previously approved for it. An observational, single-center, cross-sectional study carried out by consulting the database previously built for the project described above. Thirty-six patients were chosen from the pool of patients followed in hypertension/nephrology consultations at Hospital Amato Lusitano, who simultaneously had the diagnosis of hypertension/obesity or hypertension/metabolic syndrome. These patients were studied according to the results of their biopsy of subcutaneous abdominal adipose tissue (through the percentage of perivascular macrophages and total macrophages), insulin resistance index (through blood glycated hemoglobin and visceral adiposity index), blood values of vitamin D, T lymphocytes, non-HDL cholesterol, total cholesterol and triglycerides, abdominal perimeter and body mass index. The SPSSv17.0 software was used for the statistical analysis of the data. Results: There was a moderate inverse correlation between vitamin D and perivascular macrophages (r=-0.387; p=0.024). There was also a moderate positive association between perivascular macrophages and blood triglycerides (r=0.429; p=0.011), as well as between total cholesterol and T lymphocytes (r=0.375; p=0.026). Conclusion: The increase in the inflammatory parameters (perivascular macrophages and T lymphocytes) is synchronous with the increase in values that allowed the characterization of the metabolic syndrome of each patient (triglycerides and total cholesterol), respectively. An inverse correlation was also found between vitamin D and perivascular macrophages, both used to quantify the individuals' baseline inflammation level. Additional studies will be needed to further characterize the relationship between these variables.
Description
Keywords
Insulino-Resistência Macrófagos Obesidade Perímetro Abdominal Tecido Adiposo Subcutâneo