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Authors
Abstract(s)
Introdução: A dor é uma experiência multidimensional, desagradável, que envolve não
só um componente sensorial mediada pelo córtex Somatossensorial Primário (SI), mas
também um componente emocional totalmente subjetivo. A estimulação Theta Burst
(TBS) é uma técnica de neuroestimulação e neuromodulação não invasiva, promissora
na modulação da dor, ainda com poucos estudos de aplicação no SI.
Objetivo: Pretendeu-se estudar os efeitos da estimulação TBS contínua (cTBS) com
ação inibitória, sobre o limiar álgico em jovens adultos saudáveis, após aplicação no SI.
Metodologia: Realizou-se um estudo experimental, prospetivo, controlado,
aleatorizado e duplamente cego. Recorreu-se a uma amostra de 30 voluntários saudáveis
entre os 19 e os 29 anos (média 22,93±2,27 anos), aleatoriamente atribuídos por dois
grupos – intervenção com cTBS e placebo. A estimulação consistiu numa única sessão,
associando-se a avaliação dos limiares álgicos com estímulos elétricos repetidos a 1 e 5
Hz, antes e após cTBS/placebo (sham) no SI. A perceção subjetiva da dor foi mensurada
com recurso a escalas da dor.
Resultados: Não se verificaram efeitos da cTBS nem efeitos do grupo, assim como
alterações significativas dos limiares álgicos e na avaliação das escalas da dor nos grupos
cTBS e placebo. Não obstante, obteve-se um aumento marginalmente significativo do
limiar álgico de 1 Hz após estimulação cTBS (p=0.056).
Conclusão: A aplicação de uma sessão única de cTBS no SI contralateral parece não
surtir efeitos significativos nos limiares álgicos, parecendo não alterar de igual modo a
perceção subjetiva da dor. É recomendada mais investigação da técnica e sua
aplicabilidade no SI.
Background: Pain is a multidimensional and unpleasant experience, involving not only a sensory component mediated by the Primary Somatosensory Cortex (SI), but also a total subjective emotional component. Theta Burst Stimulation (TBS) is a non invasive neurostimulating and neuromodulating technique with promising results in pain modulation, with a reduced number of investigations regarding its application in this field. Objective: The purpose of our investigation was to study the effects of inhibitory continuous TBS (cTBS) on SI over the pain threshold in young healthy adults. Methods: This is an experimental, prospective, controlled, randomized, and doubleblind study. Thirty healthy volunteers with ages comprehended between 19 and 29 years old (average age of 22,93±2,27 years) were randomly distributed over two groups – cTBS or placebo (sham) intervention. The stimulation consisted of a single session in which pain thresholds were measured before and after application of cTBS/sham over the SI, using electric stimuli repeated at 1 and 5 Hz. Pain subjective perception was measured by the use of verified pain scales. Results: There weren’t significant cTBS and group effects, as well as significant changes on pain thresholds and pain scales evaluation on cTBS and placebo groups. Conversely, we found a marginal statistical significance increase of the 1 Hz pain threshold at cTBS group (p=0,056). Conclusion: A single session of cTBS on contralateral SI doesn’t seem to have significant effects on pain threshold as well as on subjective pain perception. Further research with this technique and its usage on SI is recommended.
Background: Pain is a multidimensional and unpleasant experience, involving not only a sensory component mediated by the Primary Somatosensory Cortex (SI), but also a total subjective emotional component. Theta Burst Stimulation (TBS) is a non invasive neurostimulating and neuromodulating technique with promising results in pain modulation, with a reduced number of investigations regarding its application in this field. Objective: The purpose of our investigation was to study the effects of inhibitory continuous TBS (cTBS) on SI over the pain threshold in young healthy adults. Methods: This is an experimental, prospective, controlled, randomized, and doubleblind study. Thirty healthy volunteers with ages comprehended between 19 and 29 years old (average age of 22,93±2,27 years) were randomly distributed over two groups – cTBS or placebo (sham) intervention. The stimulation consisted of a single session in which pain thresholds were measured before and after application of cTBS/sham over the SI, using electric stimuli repeated at 1 and 5 Hz. Pain subjective perception was measured by the use of verified pain scales. Results: There weren’t significant cTBS and group effects, as well as significant changes on pain thresholds and pain scales evaluation on cTBS and placebo groups. Conversely, we found a marginal statistical significance increase of the 1 Hz pain threshold at cTBS group (p=0,056). Conclusion: A single session of cTBS on contralateral SI doesn’t seem to have significant effects on pain threshold as well as on subjective pain perception. Further research with this technique and its usage on SI is recommended.
Description
Keywords
Córtex Somatossensorial Primário Ctbs Escalas da Dor Estimulação Magnética Transcraniana Repetitiva Estimulação Theta Burst Contínua Limiar Álgico Si