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Abstract(s)
Objetivo: A presente dissertação teve como principal objetivo identificar as áreas
cerebrais com funcionamento anormal e disfuncional de indivíduos com perturbação
depressiva major (PDM), recorrendo a imagem por ressonância magnética funcional,
aquando da realização de tarefas que estimulam a memória de trabalho.
Método: Realizou-se uma revisão sistemática da literatura (RSL) seguindo os princípios
do PRISMA para organizar e fundamentar todas as fases envolvidas ao longo do
processo de uma RSL. A pesquisa, efetuada na Web of Science e Scopus, abrangeu
estudos que envolvessem a avaliação da memória de trabalho em participantes com
perturbação depressiva major através de imagem por ressonância magnética funcional.
No total foram incluídos 14 artigos com datas compreendidas entre 2003 e 2021.
Resultados: Após a análise dos 14 estudos quantitativos publicados em revistas
científicas, os resultados obtidos demonstram que os indivíduos com perturbação
depressiva major revelam alterações em todos os quatro lobos do córtex cerebral, no
córtex cingulado, corpo caloso, corpo estriado, tálamo e ainda no cerebelo.
Conclusão: Os lobos frontal e parietal, o corpo estriado, corpo caloso e tálamo
apresentam, de uma forma geral, uma menor ativação cerebral em pacientes com PDM,
durante a realização de tarefas de memória de trabalho (MT). Para tarefas verbais e não
verbais de MT, o córtex pré-frontal dorsolateral (CPFDL) direito e o CPFDL esquerdo
apresentam ativações opostas. Para tarefas semelhantes de MT, os lobos temporal e
occipital, o córtex cingulado posterior e cerebelo não apresentam resultados
consensuais entre os artigos que os referem. Os indivíduos com depressão exibem
aumento de ativação cerebral no córtex cingulado anterior para tarefas verbais de MT,
exceto na versão 3-back da tarefa de n-back.
Objective: The main objective of this dissertation was to identify the brain areas with abnormal and dysfunctional functioning in individuals with major depressive disorder (MDD), using functional magnetic resonance imaging (fMRI), when performing tasks that stimulate working memory. Method: A systematic literature review (SLR) was carried out following the principles of PRISMA to organize and substantiate all the phases involved throughout the process of an SLR. The search, carried out on Web of Science and Scopus, covered studies involving the assessment of working memory in participants with major depressive disorder using functional magnetic resonance imaging. A total of 14 articles with dates between 2003 and 2021 were included. Results: After analyzing the 14 quantitative studies published in scientific journals, the results obtained show that individuals with major depressive disorder manifest alterations in all four lobes of the cerebral cortex, in the cingulate cortex, corpus callosum, corpus striatum, thalamus and also in the cerebellum. Conclusion: The frontal and parietal lobes, the corpus striatum, corpus callosum and thalamus generally show less brain activation in MDD patients when performing working memory (WM) tasks. For verbal and non-verbal WM tasks, the right dorsolateral prefrontal cortex (DLPFC) and the left DLPFC show opposite activations. For similar WM tasks, the temporal and occipital lobes, the posterior cingulate cortex and the cerebellum do not show consensual results among the articles that refer to them. Individuals with depression show increased brain activation in the anterior cingulate cortex for verbal WM tasks, except in the 3-back version of the n-back task.
Objective: The main objective of this dissertation was to identify the brain areas with abnormal and dysfunctional functioning in individuals with major depressive disorder (MDD), using functional magnetic resonance imaging (fMRI), when performing tasks that stimulate working memory. Method: A systematic literature review (SLR) was carried out following the principles of PRISMA to organize and substantiate all the phases involved throughout the process of an SLR. The search, carried out on Web of Science and Scopus, covered studies involving the assessment of working memory in participants with major depressive disorder using functional magnetic resonance imaging. A total of 14 articles with dates between 2003 and 2021 were included. Results: After analyzing the 14 quantitative studies published in scientific journals, the results obtained show that individuals with major depressive disorder manifest alterations in all four lobes of the cerebral cortex, in the cingulate cortex, corpus callosum, corpus striatum, thalamus and also in the cerebellum. Conclusion: The frontal and parietal lobes, the corpus striatum, corpus callosum and thalamus generally show less brain activation in MDD patients when performing working memory (WM) tasks. For verbal and non-verbal WM tasks, the right dorsolateral prefrontal cortex (DLPFC) and the left DLPFC show opposite activations. For similar WM tasks, the temporal and occipital lobes, the posterior cingulate cortex and the cerebellum do not show consensual results among the articles that refer to them. Individuals with depression show increased brain activation in the anterior cingulate cortex for verbal WM tasks, except in the 3-back version of the n-back task.
Description
Keywords
Memória de
Trabalho Perturbação Depressiva Major Ressonância Magnética Funcional Revisão Sistemática de Literatura