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Advisor(s)
Abstract(s)
A malária é um problema de saúde pública, significativo em mais de 100 países e gera cerca de 214 milhões de novas infeções por ano. Apesar do esforço significativo para erradicar essa doença perigosa, a falta de conhecimento sobre a sua fisiopatologia compromete o sucesso para a sua erradicação. Os parasitas protozoários do género Plasmodium, responsáveis por causar malária são extremamente recetivos ao stress oxidativo durante sua fase de vida intraeritrocítica, pois devoram a hemoglobina dentro de seus vacúolos e geram porções de heme tóxico e espécies reativas de oxigénio EROs. As espécies reativas de oxigênio (ERO) e nitrogênio (ERN) estão associadas ao stress oxidativo em muitas doenças e nas complicações sistêmicas originadas pela malária. A infeção por malária provoca a formação de radicais hidroxilo (•OH), que é a principal razão para a indução de stress oxidativo e apoptose. As moléculas redox e o NO desempenham diversas funções no parasita e no hospedeiro mais concretamente no mecanismo de defesa do hospedeiro contra uma variedade de parasitas e infeções por protozoários, incluindo o Plasmodium. O objetivo deste trabalho consubstanciou-se em analisar o impacto do stress oxidativo e dos sistemas redox biológicos na Malária, com uma breve incursão sobre os potenciais benefícios do uso de suplementos antioxidantes de origem sintética ou natural como uma estratégia antimalárica adjuvante.
Malaria is a significant public health problem in more than 100 countries and generates about 214 million new infections per year. Despite the significant effort to eradicate this dangerous disease, the lack of knowledge about its pathophysiology compromises success for its total eradication. Protozoan parasites of the Plasmodium genus, responsible for causing malaria, are extremely receptive to oxidative stress during their intraeritrocytic life phase, as they devour hemoglobin within their vacuoles and generate portions of toxic heme and reactive oxygen species ROS. The reactive species of oxygen (ROS) and nitrogen (RNS) are associated with oxidative stress in many diseases and in the systemic complications originated by malaria. Malaria infection causes the formation of hydroxyl radicals (•OH), which is the main reason for the induction of oxidative stress and apoptosis. The redox and NO molecules perform various functions in the parasite and the host more specifically in the host defense mechanism against a variety of parasites and protozoan infections, including Plasmodium. The objective of this work is to analysis the impact of oxidative stress and the biological redox systems in Malaria, with a small foray into the potential benefits of the use of antioxidant supplements of synthetic or natural origin as an adjuvant antimalarial strategy.
Malaria is a significant public health problem in more than 100 countries and generates about 214 million new infections per year. Despite the significant effort to eradicate this dangerous disease, the lack of knowledge about its pathophysiology compromises success for its total eradication. Protozoan parasites of the Plasmodium genus, responsible for causing malaria, are extremely receptive to oxidative stress during their intraeritrocytic life phase, as they devour hemoglobin within their vacuoles and generate portions of toxic heme and reactive oxygen species ROS. The reactive species of oxygen (ROS) and nitrogen (RNS) are associated with oxidative stress in many diseases and in the systemic complications originated by malaria. Malaria infection causes the formation of hydroxyl radicals (•OH), which is the main reason for the induction of oxidative stress and apoptosis. The redox and NO molecules perform various functions in the parasite and the host more specifically in the host defense mechanism against a variety of parasites and protozoan infections, including Plasmodium. The objective of this work is to analysis the impact of oxidative stress and the biological redox systems in Malaria, with a small foray into the potential benefits of the use of antioxidant supplements of synthetic or natural origin as an adjuvant antimalarial strategy.
Description
Keywords
Antioxidants. Free Radicals Malaria Oxidative Stress