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Advisor(s)
Abstract(s)
Introdução: A utilização de medicamentos antidepressivos, fármacos mais prescritos para o
tratamento da depressão, tem vindo a aumentar nos últimos anos. As várias classes de
antidepressivos diferem no seu mecanismo de acção farmacológico e também no perfil de
efeitos adversos e potenciais interacções farmacológicas. Estes aspectos podem influenciar a
selecção dos medicamentos antidepressivos e a adesão do doente à terapêutica.
Objectivo: Caracterizar o perfil de utilização de medicamentos antidepressivos na Beira
Interior em função de variáveis sócio-demográficas e farmacológicas.
Material e métodos: Efectuou-se um estudo observacional descritivo e transversal, nas
farmácias comunitárias dos distritos da Guarda e de Castelo Branco. Foi utilizada uma
amostra de conveniência constituída por 404 utentes utilizadores de medicamentos
antidepressivos. A informação relativa a cada utente foi obtida através da aplicação de um
questionário de caracterização sócio-demográfica e outro de caracterização farmacológica.
Resultados: Dos 404 utentes estudados, com idades compreendidas entre 16 e 90 anos, 312
eram mulheres (77%). A média de idade dos indivíduos a tomar um antidepressivo foi de 55,6
anos. Entre os utilizadores de antidepressivos 55,7% estavam a tomar um inibidor selectivo da
recaptação de serotonina (ISRS). Os três fármacos mais amplamente prescritos nessa classe
foram a fluoxetina (34,7%), a sertralina (24%) e o escitalopram (22,2%). Os utentes que
estavam a tomar concomitantemente 2 ou mais fármacos representaram 16,1% do total da
amostra e os antidepressivos tricíclicos (ATCs) e inibidores da monoamina oxidase (IMAO)
foram os menos utilizados. Para 51% dos doentes, o tratamento antidepressivo foi prescrito
pelo clínico geral, e estes prescreveram mais ISRS e menos ATCs em relação aos médicos
especialistas.
Conclusão: As mulheres utilizam mais medicamentos antidepressivos que os homens. O clínico
geral prescreve mais antidepressivos que o psiquiatra e médicos de outras especialidades. A
monoterapia é o regime terapêutico mais utilizado e os ISRS são os antidepressivos mais
prescritos.
Introduction: The use of antidepressant drugs, most commonly prescribed drugs for the treatment of depression, has been increasing in recent years. The diverse classes of antidepressants differ in their mechanism of action and also the adverse effects profile and potential drugs interactions. These aspects may influence the selection of antidepressant medications and the adherence of the patient to therapy. Goal: To characterize the profile of the use of antidepressants in Beira Interior in terms of socio-demographic and pharmacological variables. Material and methods: It was taken an observational, descriptive and cross-sectional study in the community pharmacies in the district of Guarda and Castelo Branco. It was used a convenience sample consisting of 404 users of antidepressant medication. Information on each patient was obtained by applying a questionnaire on socio-demographic and other on pharmacological characterization. Results: Of the 404 studied users, aged between 16 and 90 years, 312 were women (77%). The average age of people taking an antidepressant was of 55.6 years. Among the users of antidepressants 55.7% were taking a selective serotonin reuptake inhibitor (SSRI). The three most widely prescribed drugs in that class were fluoxetine (34.7%), sertraline (24%) and escitalopram (22.2%). The users who were taking two or more drugs concurrently represented 16.1% of the total sample and tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors were the least used. For 51% of the patients, antidepressant treatment was prescribed by a general practitioner, who prescribed more SSRIs than TCAs in relation to medical specialists. Conclusion: Women use more antidepressants than men. The general practitioner prescribes more antidepressants than the psychiatrist or other medical experts. Monotherapy regimen is the most used and SSRIs are the most commonly prescribed antidepressants.
Introduction: The use of antidepressant drugs, most commonly prescribed drugs for the treatment of depression, has been increasing in recent years. The diverse classes of antidepressants differ in their mechanism of action and also the adverse effects profile and potential drugs interactions. These aspects may influence the selection of antidepressant medications and the adherence of the patient to therapy. Goal: To characterize the profile of the use of antidepressants in Beira Interior in terms of socio-demographic and pharmacological variables. Material and methods: It was taken an observational, descriptive and cross-sectional study in the community pharmacies in the district of Guarda and Castelo Branco. It was used a convenience sample consisting of 404 users of antidepressant medication. Information on each patient was obtained by applying a questionnaire on socio-demographic and other on pharmacological characterization. Results: Of the 404 studied users, aged between 16 and 90 years, 312 were women (77%). The average age of people taking an antidepressant was of 55.6 years. Among the users of antidepressants 55.7% were taking a selective serotonin reuptake inhibitor (SSRI). The three most widely prescribed drugs in that class were fluoxetine (34.7%), sertraline (24%) and escitalopram (22.2%). The users who were taking two or more drugs concurrently represented 16.1% of the total sample and tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors were the least used. For 51% of the patients, antidepressant treatment was prescribed by a general practitioner, who prescribed more SSRIs than TCAs in relation to medical specialists. Conclusion: Women use more antidepressants than men. The general practitioner prescribes more antidepressants than the psychiatrist or other medical experts. Monotherapy regimen is the most used and SSRIs are the most commonly prescribed antidepressants.
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Keywords
Medicamentos antidepressivos Medicamentos antidepressivos - Utilização Medicamentos antidepressivos - Utilização - Beira Interior Depressão - Antidepressivos
Citation
Publisher
Universidade da Beira Interior