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Abstract(s)
Este relatório de estágio é composto por duas partes. A parte A descreve o trabalho de investigação onde se analisaram os efeitos do tratamento de hipertensão na gravidez. A parte B diz respeito ao relatório do trabalho desenvolvido em farmácia comunitária.
O objetivo do estudo descrito na parte A consiste em analisar os efeitos da terapêutica da hipertensão na gravidez. As razões que conduziram a este estudo prendem-se com a necessidade de clarificar o risco-benefício do uso de determinados grupos terapêuticos na gravidez e avaliar como estes grupos poderão ter implicações no feto e na mãe. Para isso, recorreu-se a uma breve descrição dos dados relacionados e a duas meta-análises. As meta-análises foram utilizadas no sentido de avaliar a existência de uma associação entre o tipo de fármacos anti-hipertensivos utilizados na gravidez e um possível risco em obter recém-nascidos com um índice de Apgar inferior a 7 aos 5 minutos. Utilizaram-se seis ensaios clínicos aleatorizados controlados para a realização das duas meta-análises que comparavam a hidralazina e o labetalol com outros fármacos anti-hipertensivos. As comparações diretas entre os vários pares de fármacos não nos permitem concluir que algum dos fármacos administrados aumente o risco de Apgar < 7 comparativamente com os restantes. Em termos do valor do índice de Apgar, a escolha do fármaco anti-hipertensivo a administrar revelou-se irrelevante.
Na parte B, o relatório de estágio em farmácia comunitária representa o trabalho desenvolvido durante 800 horas na Farmácia do Rio, na Covilhã. Este relatório descreve a farmácia onde foi realizado o estágio, equipamentos, quadro técnico, regulamentos, procedimentos internos, aconselhamento farmacêutico na dispensa e outros dados importantes aprendidos durante a realização do estágio em farmácia comunitária.
This report is composed of two sections. Section A describes the research analysis of the efects of hypertension treatment during pregnancy. Section B reports field work in a community pharmacy. The aim of the study described in section A is the analysis of therapeutic effects in pregnancy hypertension. This study was driven by the need to further assess the risk-benefit ratio of the use of specific therapeutic groups during pregnancy and evaluate potential maternal and fetal implications. To this end, a summary of related data was described and two meta-analyses were conducted. Meta-analyses were used to evaluate the existence of an association between the type of anti-hypertensive drugs used during pregnancy and the potential risk of newborns with an Apgar score below 7 at 5 minutes. Data from six randomised controlled clinical trials were used to perform the meta-analyses looking at the effects of hidralazine and labetalol compared to other anti-hypertensive drugs. Direct comparisons between the different sets of drugs do not allow any conclusions to be drawn regarding an increased risk of Apgar <7. In terms of Apgar score, the choice of antihypertensive drug was irrelevant. Section B describes the field work developed for a total of 800 hours in the community pharmacy Farmácia do Rio, Covilhã. This report describes the pharmacy site, available equipment, technical board, regulations, internal procedures, pharmaceutical counseling for dispensing medication and other important concepts learned and developed during the training period in community pharmacy.
This report is composed of two sections. Section A describes the research analysis of the efects of hypertension treatment during pregnancy. Section B reports field work in a community pharmacy. The aim of the study described in section A is the analysis of therapeutic effects in pregnancy hypertension. This study was driven by the need to further assess the risk-benefit ratio of the use of specific therapeutic groups during pregnancy and evaluate potential maternal and fetal implications. To this end, a summary of related data was described and two meta-analyses were conducted. Meta-analyses were used to evaluate the existence of an association between the type of anti-hypertensive drugs used during pregnancy and the potential risk of newborns with an Apgar score below 7 at 5 minutes. Data from six randomised controlled clinical trials were used to perform the meta-analyses looking at the effects of hidralazine and labetalol compared to other anti-hypertensive drugs. Direct comparisons between the different sets of drugs do not allow any conclusions to be drawn regarding an increased risk of Apgar <7. In terms of Apgar score, the choice of antihypertensive drug was irrelevant. Section B describes the field work developed for a total of 800 hours in the community pharmacy Farmácia do Rio, Covilhã. This report describes the pharmacy site, available equipment, technical board, regulations, internal procedures, pharmaceutical counseling for dispensing medication and other important concepts learned and developed during the training period in community pharmacy.
Description
Keywords
Fármacos anti-hipertensivos Hipertensão na gravidez