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Abstract(s)
O presente relatório para a obtenção do grau de mestre é composto por três capítulos, sendo o Capítulo I referente à experiência profissionalizante na vertente de investigação, o Capítulo II referente à vertente de farmácia comunitária e o Capítulo III referente à vertente de farmácia hospitalar.
O Capítulo I descreve o trabalho de investigação desenvolvido no Centro de Investigação em Ciências da Saúde, da Universidade da Beira Interior. O principal objetivo do trabalho de investigação foi determinar a atividade antimicrobiana de extratos de plantas contra diversos microrganismos, abrangendo bactérias Gram-positivas, bactérias Gram-negativas e leveduras. Mais especificamente, quatro extratos vegetais, designadamente o extrato hidroalcóolico de Echinacea purpúrea, os extratos de acetona, o metanólico e o metanólico a 70% de Helychrisum italicum; e cinco óleos essenciais, nomeadamente de Foeniculum vulgare, de Margotia gumífera, de Mentha Cervina, de Origanum majorana e de Ridolfia segetum; foram testados contra 5 estirpes de bactérias Gram-positivas, contra 9 estirpes de bactérias Gram-negativas e contra 14 estirpes de leveduras. Os resultados sugerem que o óleo essencial de Ridolfia segetum (CMI=2.5-0.31µL/mL) e Mentha cervina (CMI=2.5-0.16µL/mL) apresentam boa atividade antimicrobiana contra bactérias e leveduras. Por sua vez, o óleo essencial de Foeniculum vulgare demostra uma interessante atividade anti-Candida (CMI=0.63-2.5µL/mL). Os restantes extratos de plantas testados apresentaram uma reduzida ou ausente atividade antimicrobiana.
O Capitulo II relata o estágio em Farmácia Comunitária decorrido entre 26 de janeiro e 17 de abril de 2015, na Farmácia Perdigão (Caldas da Rainha), sob a orientação Dr.ª Maria José Perdigão. Pretende-se como este capítulo referir as principais atividades desenvolvidas durante o período de estágio, desde o circuito do medicamento à dispensa de medicamentos e outros produtos de saúde, passando pela gestão da farmácia e o aconselhamento farmacêutico.
O Capitulo III relata o estágio em Farmácia Hospitalar decorrido entre 20 de abril e 12 de junho de 2015, no Hospital Amato Lusitano (Castelo Branco) sob a orientação da Dr.ª Sandra Queimado. Pretende-se como este capítulo referir as principais atividades desenvolvidas durante o período de estágio, desde as funções administrativas às funções clínicas que o farmacêutico desempenha a nível hospitalar.
This report consists of three chapters: Chapter I related to the professional experience in research, Chapter II related to the professional internship in community pharmacy and Chapter III related to professional internship in hospital pharmacy. Chapter I describes the research work developed at the Research Center for Health Sciences, University of Beira Interior. The main purpose of the research work was to determine the antimicrobial activity of plant extracts against distinct microorganisms, including Gram-positive bacteria, Gram-negative bacteria and yeasts. More specifically, four plant extracts, in particular the hydroalcoholic extract of Echinacea purpurea, the acetone, methanol and methanol 70% extracts of Helychrisum italicum; and five essential oils, in particular from Foeniculum vulgare, Margotia gumífera, Mentha cervina, Origanum majorana and Ridolfia segetum were tested against 5 strains of Gram-positive bacteria, 9 strains of Gram-negative bacteria and 14 strains of yeasts. The results suggest that the essential oil Ridolfia segetum (MIC=2.5-0.31µL/ml) and Mentha cervina (MIC=2.5-0.16µL/ml) exhibit good antimicrobial activity against bacteria and yeast. In turn, the essential oil of Foeniculum vulgare demonstrates an interesting anti-Candida activity (MIC=0.63-2.5µL/mL). The remaining tested plant extracts showed a reduced or absent antimicrobial activity. Chapter II reports the internship in Community Pharmacy that occurred between January 26th and April 17th of 2015, at Farmácia Perdigão (Caldas da Rainha), under the guidance of Dr.ª Maria José Perdigão. This chapter describes the activities developed during the internship, beginning with the circuit of the drug, the dispensing of drugs and health products, the management of the pharmacy and ending with the pharmacist advice. Chapter III reports the internship in Hospital Pharmacy that occurred between April 20th and June 12th h of 2015, at Hospital Amato Lusitano (Castelo Branco) under the guidance of Dr.ª Sandra Queimado. This chapter describes the activities developed during the internship, focusing administrative functions and clinical functions that the pharmacist performs in hospital.
This report consists of three chapters: Chapter I related to the professional experience in research, Chapter II related to the professional internship in community pharmacy and Chapter III related to professional internship in hospital pharmacy. Chapter I describes the research work developed at the Research Center for Health Sciences, University of Beira Interior. The main purpose of the research work was to determine the antimicrobial activity of plant extracts against distinct microorganisms, including Gram-positive bacteria, Gram-negative bacteria and yeasts. More specifically, four plant extracts, in particular the hydroalcoholic extract of Echinacea purpurea, the acetone, methanol and methanol 70% extracts of Helychrisum italicum; and five essential oils, in particular from Foeniculum vulgare, Margotia gumífera, Mentha cervina, Origanum majorana and Ridolfia segetum were tested against 5 strains of Gram-positive bacteria, 9 strains of Gram-negative bacteria and 14 strains of yeasts. The results suggest that the essential oil Ridolfia segetum (MIC=2.5-0.31µL/ml) and Mentha cervina (MIC=2.5-0.16µL/ml) exhibit good antimicrobial activity against bacteria and yeast. In turn, the essential oil of Foeniculum vulgare demonstrates an interesting anti-Candida activity (MIC=0.63-2.5µL/mL). The remaining tested plant extracts showed a reduced or absent antimicrobial activity. Chapter II reports the internship in Community Pharmacy that occurred between January 26th and April 17th of 2015, at Farmácia Perdigão (Caldas da Rainha), under the guidance of Dr.ª Maria José Perdigão. This chapter describes the activities developed during the internship, beginning with the circuit of the drug, the dispensing of drugs and health products, the management of the pharmacy and ending with the pharmacist advice. Chapter III reports the internship in Hospital Pharmacy that occurred between April 20th and June 12th h of 2015, at Hospital Amato Lusitano (Castelo Branco) under the guidance of Dr.ª Sandra Queimado. This chapter describes the activities developed during the internship, focusing administrative functions and clinical functions that the pharmacist performs in hospital.
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Keywords
Atividade Antimicrobiana Extrato Farmácia Comunitária Farmácia Hospitalar Planta