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Abstract(s)
Introdução: A oxitocina é uma hormona classicamente conhecida pelos seus efeitos
no parto e na amamentação, sendo a sua aplicação mais conhecida na prática clínica
em Obstetrícia para induzir o trabalho de parto. Atualmente têm-se descoberto novas
funções. Vários ensaios pré-clínicos documentaram propriedades anorexígenas da
oxitocina, tanto a nível da ingestão calórica, do dispêndio energético e do peso corporal.
Atualmente, a obesidade é bastante prevalente a nível mundial, acarretando inúmeros
problemas de saúde associados. Existem inúmeras terapêuticas propostas para o seu
tratamento, sendo a oxitocina uma solução potencial, ainda em pesquisa.
O objetivo deste trabalho foi analisar a evidência científica da utilidade da oxitocina no
controlo do apetite e do peso.
Materiais e métodos: O presente trabalho foi realizado através da pesquisa
bibliográfica de artigos científicos na base de dados “PubMed/MEDLINE” com recurso
às palavras-chave “oxytocin”, “obesity”, “food intake” e “appetite”. Foram selecionados
preferencialmente ensaios clínicos randomizados.
Resultados: Foram identificados 18 ensaios clínicos randomizados que foram alvo de
uma análise mais detalhada. A generalidade dos estudos revelou benefícios a nível da
ingestão alimentar, de parâmetros metabólicos e do controlo cognitivo perante a
visualização de estímulos alimentares. No entanto, a globalidade dos estudos não
revelou diminuições significativas de peso.
Discussão: Os dados nesta temática são ainda incertos. Amostras pequenas,
heterogéneas, tempos reduzidos de estudo, desenhos diferentes das investigações,
dosagens distintas e falta de conhecimento das propriedades farmacológicas da
oxitocina poderão explicar esta incerteza.
Conclusão: No futuro, é importante continuar a realizar mais estudos, com amostras
maiores e durante um intervalo de tempo mais prolongado, para obter resultados mais
fidedignos, sempre atentando à ocorrência potencial de eventos adversos.
Introduction: Oxytocin is a hormone classically known for its effects on childbirth and breastfeeding, and its best known application in clinical practice is in obstetrics to induce labor. Currently, new functions have been discovered. Several preclinical trials have documented anorexigenic properties of oxytocin, both in terms of caloric intake, energy expenditure and body weight. Obesity is quite prevalent worldwide, causing numerous associated health problems. There are numerous therapies proposed for its treatment, with oxytocin being a potential solution, still under research. The aim of this work was to analyze the scientific evidence of the usefulness of oxytocin in controlling appetite and weight. Materials and methods: The present work was undertaked by a literature search of scientific articles in the database "PubMed / MEDLINE" using the keywords "oxytocin", "obesity", "food intake" and "appetite". Randomized clinical trials were preferably selected. Results: This monograph identified 18 randomized clinical trials that were the subject of a more detailed analysis. Most studies have shown benefits in terms of food intake, metabolic parameters and cognitive control when viewing food stimuli. However, the studies as a whole did not reveal significant decreases in weight. Discussion: The data on this topic are still uncertain. Small, heterogeneous samples, reduced study times, different designs of investigations, different dosages and lack of knowledge of the pharmacological properties of oxytocin may explain this uncertainty. Conclusion: In the future, it is important to continue to carry out more studies, with larger samples and over a longer period of time, to obtain more reliable results, always paying attention to the potential occurrence of adverse events.
Introduction: Oxytocin is a hormone classically known for its effects on childbirth and breastfeeding, and its best known application in clinical practice is in obstetrics to induce labor. Currently, new functions have been discovered. Several preclinical trials have documented anorexigenic properties of oxytocin, both in terms of caloric intake, energy expenditure and body weight. Obesity is quite prevalent worldwide, causing numerous associated health problems. There are numerous therapies proposed for its treatment, with oxytocin being a potential solution, still under research. The aim of this work was to analyze the scientific evidence of the usefulness of oxytocin in controlling appetite and weight. Materials and methods: The present work was undertaked by a literature search of scientific articles in the database "PubMed / MEDLINE" using the keywords "oxytocin", "obesity", "food intake" and "appetite". Randomized clinical trials were preferably selected. Results: This monograph identified 18 randomized clinical trials that were the subject of a more detailed analysis. Most studies have shown benefits in terms of food intake, metabolic parameters and cognitive control when viewing food stimuli. However, the studies as a whole did not reveal significant decreases in weight. Discussion: The data on this topic are still uncertain. Small, heterogeneous samples, reduced study times, different designs of investigations, different dosages and lack of knowledge of the pharmacological properties of oxytocin may explain this uncertainty. Conclusion: In the future, it is important to continue to carry out more studies, with larger samples and over a longer period of time, to obtain more reliable results, always paying attention to the potential occurrence of adverse events.
Description
Keywords
Apetite Endocrinologia Hormonas Ingestão Alimentar Obesidade Oxitocina Peso