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Resumo(s)
A psilocibina é um alcaloide indólico presente nos cogumelos do género Psilocybe e é
frequentemente conhecida pelas suas propriedades alucinogénias. Esta substância atua no
cérebro ao nível dos recetores de serotonina provocando efeitos transitórios a nível da
cognição, da perceção e da emoção. Atualmente, esta substância tem sido envolvida em
vários estudos que têm demonstrado a sua segurança e a sua eficácia terapêutica em
algumas doenças neuropsiquiátricas, como a depressão.
Este trabalho teve como principal objetivo analisar o impacto da psilocibina na depressão,
auscultando a sua eficácia a nível sintomático, os seus efeitos adversos e contraindicações.
Através da revisão de literatura foi possível verificar que, em conjunto com psicoterapia,
uma elevada dose de psilocibina é capaz de suscitar benefícios clínicos rápidos e
sustentados, sem efeitos adversos significativos.
Psilocybin is an indolic alkaloid present in Psilocybe mushrooms and is often known for its hallucinogenic properties. This substance acts in the brain at the level of serotonin receptors, causing transient effects in terms of cognition, perception and emotion. Currently, this substance has been involved in several studies that have demonstrated its safety and therapeutic efficacy in some neuropsychiatric diseases, such as depression. The primary goal of this work was to analyse the impact of psilocybin on depression, considering its symptomatic effectiveness, its adverse effects and its contraindications. Through the literature review, it was possible to verify that, in association with psychotherapy, a high dose of psilocybin induces rapid and sustained clinical benefits, without adverse effects.
Psilocybin is an indolic alkaloid present in Psilocybe mushrooms and is often known for its hallucinogenic properties. This substance acts in the brain at the level of serotonin receptors, causing transient effects in terms of cognition, perception and emotion. Currently, this substance has been involved in several studies that have demonstrated its safety and therapeutic efficacy in some neuropsychiatric diseases, such as depression. The primary goal of this work was to analyse the impact of psilocybin on depression, considering its symptomatic effectiveness, its adverse effects and its contraindications. Through the literature review, it was possible to verify that, in association with psychotherapy, a high dose of psilocybin induces rapid and sustained clinical benefits, without adverse effects.
Descrição
Palavras-chave
Alucinogénios Depressão Psilocibina Terapêutica Não Farmacológica