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Abstract(s)
Introdução
O cancro colorretal representa um dos maiores desafios de saúde pública no mundo e é o cancro mais diagnosticado em Portugal, apresentando uma tendência crescente de incidência. É, desta forma, uma prioridade de intervenção na saúde oncológica, tanto a nível nacional como internacional. Existem diferenças no padrão epidemiológico do cancro colorretal ao longo do país, sendo o interior uma região suscetível a um maior impacto da doença. Esta é uma doença heterogénea, sendo que a escolha da abordagem terapêutica a adotar é cada vez mais adaptada às características dos pacientes e do tumor. Desta forma, é imprescindível que cada instituição conheça a realidade regional da doença, no sentido de se adaptar às suas necessidades e prestar os cuidados de maior qualidade possível aos seus doentes.
Objetivos
Este estudo pretende caracterizar o carcinoma colorretal na Cova da Beira ao nível da distribuição por género e idade, estadiamento no momento do diagnóstico, localização do tumor, grau de diferenciação, infiltração linfática, vascular e perineural, local de metastização e presença de mutação RAS. Desta forma, o estudo poderá permitir ao Centro Hospitalar Universitário da Cova da Beira um maior conhecimento da realidade dos seus utentes e da população local com esta patologia, podendo adequar a sua atuação de acordo com as suas características.
Métodos
Estudo epidemiológico observacional retrospetivo dos doentes com carcinoma colorretal da região da Cova da Beira. Os dados foram recolhidos a partir dos registos clínicos dos doentes diagnosticados com cancro colorretal do Centro Hospitalar Universitário da Cova da Beira entre 2017 e 2018. Foram recolhidos os dados referentes à idade, género, estadio ao diagnóstico, grau de diferenciação, localização do tumor, infiltrações linfática, vascular e perineural, local de metastização e status para a mutação do gene RAS. A análise estatística dos dados foi realizada com recurso ao software IBM SPSS 25.0®. Os resultados foram considerados estatisticamente significativos para p<0,05. Resultados
Na Cova da Beira, a maioria dos casos de carcinoma colorretal foram diagnosticados em pacientes do género masculino e com idades entre os 75 e 85 anos. Os tumores apresentaram-se mais no cólon esquerdo, no estadio III da classificação TNM e com grau de diferenciação G2. A maioria dos casos não apresentou nenhum tipo de infiltração tumoral. Grande parte dos casos em estadio IV apresentou metastização para mais do que um órgão, sendo o fígado o órgão mais frequentemente afetado. Metade dos casos avaliados para a mutação RAS apresentaram esta mutação, não sendo consequentemente suscetíveis às terapêuticas anti-EGFR.
Apenas as relações entre o género e a idade ao diagnóstico, entre a localização do tumor e o seu grau de diferenciação e entre o estadio e as infiltrações linfática, vascular e perineural se mostraram estatisticamente significativas neste estudo. Os doentes do género feminino tiveram um diagnóstico em idade mais avançada comparativamente ao género masculino. O cólon direito foi a localização anatómica mais afetada pelos tumores com grau de diferenciação G3. Foi verificado também um aumento da presença de infiltração linfovascular e perineural para estadios cada vez mais avançados.
Introduction Colorectal cancer is a major public health challenge in the world, and it is the most diagnosed cancer in Portugal, presenting an increasing trend of incidence. Therefore, it is a priority for intervention in cancer health, both nationally and internationally. There are differences in the epidemiological pattern of colorectal cancer throughout the country and the interior region of it is susceptible to a greater burden of the disease. Colorectal cancer is a heterogeneous disease and the choice of the therapeutic approach is increasingly individualized and adapted to the characteristics of the patients and the tumor. It is essential that each health institution recognize the regional patterns of the disease, in order to identify its needs and provide the highest possible quality care to its patients. Goals This study intends to build a characterization of the colorectal carcinoma in Cova da Beira, regarding gender and age distribution, stage at diagnosis, tumor location, grade of differentiation, lymphatic, vascular and perineural invasion, site of metastasis and status for mutation of gene RAS. Thus, this study may give Centro Hospitalar Universitário da Cova da Beira a better knowledge about the reality of its patients with this disease, allowing it to adapt its performance in accordance with the population characteristics. Methods Retrospective observational epidemiological study of the patients with colorectal carcinoma of Cova da Beira region. Data were collected from clinical records of patients diagnosed with colorectal cancer at Centro Hospitalar Universitário da Cova da Beira between 2017 and 2018. The data covers information regarding age, gender, stage at diagnosis, grade of differentiation, tumor location, lymphatic, vascular and perineural invasion, site of metastasis and staus for mutation of gene RAS. The statistical analysis was performed using the software IBM SPSS 25.0® and the results were considered statistically significant for p<0.05. Results In Cova da Beira, most cases of colorectal carcinoma were diagnosed in males and between ages 75 and 85. The tumors were more frequent in the left colon, stage III of TNM classification and grade G2 of differentiation. The majority of cases did not show any type of tumoral invasion. Most of stage IV cases presented polymetastatic disease and the liver was the organ most frequently affected. Half of the cases evaluated for the gene RAS mutation had this mutation and, therefore, were not susceptible to anti-EGFR therapies. Only the relations between gender and age at diagnosis, between the tumor location and its grade of differentiation and between the stage and the lymphatic, vascular and perineural invasions were statistically significant in this study. Females were diagnosed at a more advanced age compared to males. The right colon was the anatomical site most affected by G3 tumors. There was also an increase in the presence of lymphovascular and perineural infiltration for more advanced stages at diagnosis.
Introduction Colorectal cancer is a major public health challenge in the world, and it is the most diagnosed cancer in Portugal, presenting an increasing trend of incidence. Therefore, it is a priority for intervention in cancer health, both nationally and internationally. There are differences in the epidemiological pattern of colorectal cancer throughout the country and the interior region of it is susceptible to a greater burden of the disease. Colorectal cancer is a heterogeneous disease and the choice of the therapeutic approach is increasingly individualized and adapted to the characteristics of the patients and the tumor. It is essential that each health institution recognize the regional patterns of the disease, in order to identify its needs and provide the highest possible quality care to its patients. Goals This study intends to build a characterization of the colorectal carcinoma in Cova da Beira, regarding gender and age distribution, stage at diagnosis, tumor location, grade of differentiation, lymphatic, vascular and perineural invasion, site of metastasis and status for mutation of gene RAS. Thus, this study may give Centro Hospitalar Universitário da Cova da Beira a better knowledge about the reality of its patients with this disease, allowing it to adapt its performance in accordance with the population characteristics. Methods Retrospective observational epidemiological study of the patients with colorectal carcinoma of Cova da Beira region. Data were collected from clinical records of patients diagnosed with colorectal cancer at Centro Hospitalar Universitário da Cova da Beira between 2017 and 2018. The data covers information regarding age, gender, stage at diagnosis, grade of differentiation, tumor location, lymphatic, vascular and perineural invasion, site of metastasis and staus for mutation of gene RAS. The statistical analysis was performed using the software IBM SPSS 25.0® and the results were considered statistically significant for p<0.05. Results In Cova da Beira, most cases of colorectal carcinoma were diagnosed in males and between ages 75 and 85. The tumors were more frequent in the left colon, stage III of TNM classification and grade G2 of differentiation. The majority of cases did not show any type of tumoral invasion. Most of stage IV cases presented polymetastatic disease and the liver was the organ most frequently affected. Half of the cases evaluated for the gene RAS mutation had this mutation and, therefore, were not susceptible to anti-EGFR therapies. Only the relations between gender and age at diagnosis, between the tumor location and its grade of differentiation and between the stage and the lymphatic, vascular and perineural invasions were statistically significant in this study. Females were diagnosed at a more advanced age compared to males. The right colon was the anatomical site most affected by G3 tumors. There was also an increase in the presence of lymphovascular and perineural infiltration for more advanced stages at diagnosis.
Description
Keywords
Cancro Carcinoma Chucb Cólon Colorretal Cova da Beira Reto