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Abstract(s)
Esta dissertação encontra-se dividida em dois capítulos: Investigação e Estágio em farmácia
comunitária.
O primeiro capítulo consiste numa monografia que aborda a influência dos fitoestrogénios na
proliferação de linhagens celulares de cancro da mama hormono-dependente. Os
fitoestrogénios encontram-se numa grande quantidade de alimentos e têm uma estrutura
química semelhante ao 17ß-estradiol dos mamíferos. Por esse motivo têm despertado grande
interesse como uma provável alternativa à Terapia Hormonal de Substituição (THS) usada
pelas mulheres na menopausa. Tendo em conta que vários trabalhos indicam que a THS
clássica pode ter como efeito indesejado um aumento do risco de desenvolvimento de cancro
da mama, os fitoestrogénios apresentam-se como um possível caminho a seguir. Este estudo
tem como objetivo analisar os trabalhos publicados neste âmbito no sentido de avaliar se a
proliferação celular que se verifica com a THS está também presente quando são usados os
fitoestrogénios.
Concluiu-se que, dependendo das concentrações de fitoestrogénios e da presença ou ausência
de recetores de estrogénio nas células utilizadas, os fitoestrogénios podem exercer um efeito
de estimulação ou de inibição da proliferação celular de células de cancro da mama.
Para se tirar o máximo benefício dos fitoestrogénios têm que ser conhecidas as concentrações
exatas às quais estes não provocam a estimulação da proliferação celular. Para que tal
aconteça é necessário que se continue a aprofundar o estudo nesta área de forma
consistente.
O segundo capítulo tem como objetivo descrever todas as atividades desenvolvidas ao longo
das 800 horas de estágio na Farmácia Fernandes Machado, bem como todos os procedimentos
necessários ao funcionamento da farmácia comunitária.
This thesis is divided into two chapters: Investigation and Internship at Community Pharmacy. The first chapter consists in a dissertation that approaches the influence of phytoestrogens in hormone-dependent breast cancer cell lineages proliferation. We can find phytoestrogens in a large variety of food and they have a similar chemistry to the mammals's 17B-estradiol. For that reason it is of big interest as an alternative to the Hormonal replacement therapy (HRT) used in menopausal women. Having that many works say that the classic HRT may have as a side effect an increased risk in breast cancer development, the phytoestrogens appear as a viable approach. By that, this study has as objective analyze the present works in this area to evaluate if the cell proliferation, that is seen in the HRT is also present when phytoestrogens are used. Concludes that, depending on the concentration of phytoestrogens as well as the absence or presence of estrogen receptors in the cells, the phytoestrogens may produce a stimulation or an inhibition of breast cell's proliferation. To extract the maximum benefit from the phytoestrogens, it's needed to be known the exact concentration at which these don't cause cell proliferation. For that to happen it's needed that the work on this field keeps increasing to improve the present knowledge. The second chapter has as objective to describe all the activities developed during the 800 hours of the internship at Fernandes Machado's pharmacy, as well as all the proceedings needed to its proper function.
This thesis is divided into two chapters: Investigation and Internship at Community Pharmacy. The first chapter consists in a dissertation that approaches the influence of phytoestrogens in hormone-dependent breast cancer cell lineages proliferation. We can find phytoestrogens in a large variety of food and they have a similar chemistry to the mammals's 17B-estradiol. For that reason it is of big interest as an alternative to the Hormonal replacement therapy (HRT) used in menopausal women. Having that many works say that the classic HRT may have as a side effect an increased risk in breast cancer development, the phytoestrogens appear as a viable approach. By that, this study has as objective analyze the present works in this area to evaluate if the cell proliferation, that is seen in the HRT is also present when phytoestrogens are used. Concludes that, depending on the concentration of phytoestrogens as well as the absence or presence of estrogen receptors in the cells, the phytoestrogens may produce a stimulation or an inhibition of breast cell's proliferation. To extract the maximum benefit from the phytoestrogens, it's needed to be known the exact concentration at which these don't cause cell proliferation. For that to happen it's needed that the work on this field keeps increasing to improve the present knowledge. The second chapter has as objective to describe all the activities developed during the 800 hours of the internship at Fernandes Machado's pharmacy, as well as all the proceedings needed to its proper function.
Description
Keywords
Cancro da Mama Cultura Celular Farmácia Comunitária Fitoestrogénios Proliferação Celular Terapia Hormonal de Substituição