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Authors
Abstract(s)
Introdução: O cancro colo-rectal (CCR) é um dos cancros mais comuns, havendo evidência de que o carcinoma do cólon direito (CCD) e o do cólon esquerdo (CCE) são biológica e clinicamente diferentes, podendo estas ainda variar de acordo com as regiões geográficas. Pretendeu-se, assim, caracterizar esta patologia na Beira Interior, analisando as diferenças entre CCD e CCE.
Material e Métodos: Estudo comparativo transversal retrospetivo em doentes operados com CCD e CCE, entre 2010 e 2015, nos três hospitais da Beira Interior, analisando parâmetros demográficos e clinico-patológicos. A análise estatística efetuou-se com o SPSS? 24.
Resultados e Discussão: Após aplicação dos critérios de exclusão - doentes menores de 18 anos, carcinoma do reto e apêndice concomitante, cancro colo-rectal recidivado, impossibilidade de classificação em CCD ou CCE, dados insuficientes -, analisaram-se os processos clínicos de 457 doentes operados por CCD ou CCE. Nesta amostra, 57,3% apresentava CCD, sendo 56,9% do sexo masculino. A média das idades variou entre os 70 anos no CCE e os 72 anos no CCD. Os grupos caraterizam-se por apresentações diferentes, sendo a anemia superior no CCD e a oclusão intestinal superior no CCE (p<0,001). As restantes formas de apresentação diferem, mas a sua diferença entre grupos não se revelou estatisticamente significativa. A distribuição do estadio TNM é semelhante nos 2 grupos, sendo mais frequentemente IIA e IIIB. O tipo histológico mais frequente é o adenocarcinoma em ambos os grupos. O número de cirurgias urgentes foi superior no CCE(p=0.03).
Conclusão: Contrariamente à maioria da literatura, a amostra de carcinoma do cólon direito na Beira Interior é maior e os estadios são semelhantes nos dois grupos. No entanto, a média das idades no CCD e CCE (72,6±10,8 vs 70,2±12,7 anos; p<0,01) e a forma de apresentação, assim como a tendência para a cirurgia urgente seguem o padrão do conhecimento atual.
Background: Colorectal cancer (CRC) is one of the most common cancers, and there’s evidence that right colon cancer (RCC) and left colon cancer (LCC) are biologically and clinically different, and these may still vary according to geographical regions. The aim was to characterize this pathology in Beira Interior, analyzing the differences between RCC and LCC. Material and Methods: Retrospective cross-sectional study in patients operated with RCC and LCC, between 2010 and 2015, in the three Beira Interior hospitals, analyzing demographic and clinical-pathological parameters. Statistical analysis was performed with SPSS 24. Results and Discussion: After application of the exclusion criteria (patients under 18, carcinoma of the rectum and concomitant appendix, recurrent colorectal cancer, impossibility of classification in RCC or LCC, insufficient data), the clinical processes of 457 Patients undergoing CCD or CCE were analyzed. In this sample, 57.3% had RCC, 56.9% of them male. The age average ranged from 70 years in LCC to 72 years in RCC. The groups are characterized by different presentations, with anemia being higher in the RCC and intestinal oclusion being higher in LCC(p <0.001). The other forms of presentation differ, but their difference between groups was not statistically significant. The TNM stage distribution is similar in the 2 groups, most frequently IIA and IIIB. The most frequent histological type is the adenocarcinoma in both groups. The number of urgent surgeries was higher in LCC (p = 0.03). Conclusion: Contrary to most of the literature, the sample of right colon carcinoma in Beira Interior is larger and the stages are similar in both groups. However, the age average of the patients in the RCC and LCC (72.6 ± 10.8 vs 70.2 ± 12.7 years, p <0.01) and the presentation and tendency for urgent surgery follow the standard of current knowledge. A prospective study would allow a better analysis, as well as the creation of a National Multidisciplinary Prospective Registry of Colorectal Cancer would allow a better knowledge and characterization by region.
Background: Colorectal cancer (CRC) is one of the most common cancers, and there’s evidence that right colon cancer (RCC) and left colon cancer (LCC) are biologically and clinically different, and these may still vary according to geographical regions. The aim was to characterize this pathology in Beira Interior, analyzing the differences between RCC and LCC. Material and Methods: Retrospective cross-sectional study in patients operated with RCC and LCC, between 2010 and 2015, in the three Beira Interior hospitals, analyzing demographic and clinical-pathological parameters. Statistical analysis was performed with SPSS 24. Results and Discussion: After application of the exclusion criteria (patients under 18, carcinoma of the rectum and concomitant appendix, recurrent colorectal cancer, impossibility of classification in RCC or LCC, insufficient data), the clinical processes of 457 Patients undergoing CCD or CCE were analyzed. In this sample, 57.3% had RCC, 56.9% of them male. The age average ranged from 70 years in LCC to 72 years in RCC. The groups are characterized by different presentations, with anemia being higher in the RCC and intestinal oclusion being higher in LCC(p <0.001). The other forms of presentation differ, but their difference between groups was not statistically significant. The TNM stage distribution is similar in the 2 groups, most frequently IIA and IIIB. The most frequent histological type is the adenocarcinoma in both groups. The number of urgent surgeries was higher in LCC (p = 0.03). Conclusion: Contrary to most of the literature, the sample of right colon carcinoma in Beira Interior is larger and the stages are similar in both groups. However, the age average of the patients in the RCC and LCC (72.6 ± 10.8 vs 70.2 ± 12.7 years, p <0.01) and the presentation and tendency for urgent surgery follow the standard of current knowledge. A prospective study would allow a better analysis, as well as the creation of a National Multidisciplinary Prospective Registry of Colorectal Cancer would allow a better knowledge and characterization by region.
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Keywords
Beira Interior Carcinoma Cólon Direito Cólon Esquerdo Diferenças