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Abstract(s)
Nos dias de hoje, o desenvolvimento de sistemas dérmicos baseados em estruturas de
base celulósica biodegradáveis constitui um desafio na área da Química Industrial,
especialmente pela utilização tanto das fibras de celulose, como de moléculas ativas
provenientes de plantas, numa perspetiva de circularidade. Tem-se assistido a um
crescente interesse na utilização dos vários tipos de moléculas ativas provenientes da
Cannabis sativa L. Neste estudo, estas combinam-se com moléculas ativas de outras
plantas, entre as quais a Camellia sinensis L., com o objetivo de desenvolver formulações
com interesse comercial.
Os compostos ativos e os constituintes voláteis, presentes em ambas as plantas, foram
obtidos por hidrodestilação e microextração em fase sólida (HS-SPME), respetivamente,
e caracterizados, por cromatografia gasosa acoplada à espectrometria de massas (GCMS). Mais de 60 compostos foram caracterizados no óleo essencial de canábis e
mentrastos entre eles o ? cariofileno (14,3%) e o a terpinoleno (10,8%). A análise dos
voláteis identificou a citronela (10,3%) e o ß citronelol (8,9%) como os compostos
maioritários presentes. No chá verde da Gorreana, os principais compostos encontrados
foram o ácido palmítico e (25,5%) e a cafeína (12,8%). Neste trabalho foram
caracterizados diferentes materiais de base celulósica, de hardwood e softwood,
modificando a sua estrutura por métodos mecânicos, resultando na diminuição da
porosidade da matriz produzida de 80% para 50%, e no aumento das propriedades
mecânicas, como o módulo de elasticidade, em cerca de 6 vezes, contribuindo para o
desenvolvimento de DDS sustentáveis capazes de reter as moléculas em estudo.
Otimizaram-se os métodos de extração das fibras de Cannabis sativa L. a partir de caules
cortados e submetidos ao cozimento alcalino com NaOH a 140ºC, obtendo-se
características estruturais de acordo com os requisitos para as aplicações pretendidas. A
incorporação das fibras de cânhamo às fibras de papel industrial tissue resultaram no
aumento do índice de tração em mais de 60% e do módulo de elasticidade da estrutura
de 1650 MPa para 2318 MPa. O desenvolvimento e otimização de estruturas 3D permitiu
a obtenção de protótipos laboratoriais com potencial para serem utilizados em aplicações
dérmicas com maior sustentabilidade ambiental.
Nowadays, the development of dermal systems based on biodegradable cellulosic structures is a challenge in Industrial Chemistry, especially for the use of both cellulose fibers and active molecules from plants, in a circularity perspective. A growing interest in the use of various types of active molecules from Cannabis sativa L. has been noted. In this work, these are combined with active molecules from other plants, including Camellia sinensis L., to develop formulations with commercial interest. The active compounds and volatile constituents present in both plants were obtained by hydrodistillation and solid phase microextraction (HS-SPME), respectively, and characterized by gas chromatography coupled to mass spectrometry (GC-MS). More than 60 compounds were characterised in the cannabis essential oil, including ? caryophyllene (14.3%) and a terpinolene (10.8%). The analysis of volatiles identified citronella (10.3%) and ß citronellol (8.9%) as the main compounds. In the green tea from Gorreana, the main compounds found were palmitic acid (25.5%) and caffeine (12.8%). In this work, different cellulosic base materials, hardwood, and softwood, were characterised, modifying their structure by mechanical methods, resulting in the decrease of the porosity of the produced matrix from 80% to 50%, and in the increase of the mechanical properties, such as the modulus of elasticity, in about 6 times, with a positive contribution for the development of sustainable DDS capable of retaining the molecules under study. Methods of extraction of Cannabis sativa L. fibers from cutted stems were optimized, submitted to alkaline NaOH pulping process at 140ºC, obtaining structural characteristics in accordance with the requirements for the intended applications. The incorporation of hemp fibers to industrial tissue paper fibers resulted in an increase in the tensile index of more than 60% and in the modulus of elasticity of the structure from 1650 MPa to 2318 MPa. The development and optimization of 3D laboratorial prototypes structures with potential for dermal applications and higher environmental sustainability was accomplished.
Nowadays, the development of dermal systems based on biodegradable cellulosic structures is a challenge in Industrial Chemistry, especially for the use of both cellulose fibers and active molecules from plants, in a circularity perspective. A growing interest in the use of various types of active molecules from Cannabis sativa L. has been noted. In this work, these are combined with active molecules from other plants, including Camellia sinensis L., to develop formulations with commercial interest. The active compounds and volatile constituents present in both plants were obtained by hydrodistillation and solid phase microextraction (HS-SPME), respectively, and characterized by gas chromatography coupled to mass spectrometry (GC-MS). More than 60 compounds were characterised in the cannabis essential oil, including ? caryophyllene (14.3%) and a terpinolene (10.8%). The analysis of volatiles identified citronella (10.3%) and ß citronellol (8.9%) as the main compounds. In the green tea from Gorreana, the main compounds found were palmitic acid (25.5%) and caffeine (12.8%). In this work, different cellulosic base materials, hardwood, and softwood, were characterised, modifying their structure by mechanical methods, resulting in the decrease of the porosity of the produced matrix from 80% to 50%, and in the increase of the mechanical properties, such as the modulus of elasticity, in about 6 times, with a positive contribution for the development of sustainable DDS capable of retaining the molecules under study. Methods of extraction of Cannabis sativa L. fibers from cutted stems were optimized, submitted to alkaline NaOH pulping process at 140ºC, obtaining structural characteristics in accordance with the requirements for the intended applications. The incorporation of hemp fibers to industrial tissue paper fibers resulted in an increase in the tensile index of more than 60% and in the modulus of elasticity of the structure from 1650 MPa to 2318 MPa. The development and optimization of 3D laboratorial prototypes structures with potential for dermal applications and higher environmental sustainability was accomplished.
Description
Keywords
Camellia Sinensis L. Cannabis Sativa L. Drug Delivery Systems (Dds) Fibras de Cânhamo Fibras de Micro/Nanocelulose Materiais de Base Celulósica Sistemas
Biodegradáveis