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Abstract(s)
Introdução: A diabetes mellitus tipo 2 e a doença de Parkinson estão entre as doenças mais prevalentes na população em envelhecimento. Diversos estudos epidemiológicos têm analisado o papel da diabetes no desenvolvimento da doença de Parkinson tendo concluído, na maioria, que existe uma associação positiva entre as duas doenças. O objectivo deste trabalho foi sistematizar o conhecimento existente sobre os estudos epidemiológicos que avaliam a associação entre a diabetes mellitus tipo 2 e a doença de Parkinson, e avançar possíveis explicações biológicas para esta mesma associação.
Métodos: Revisão com base na recolha de artigos que estudam a associação entre a diabetes mellitus tipo 2 e a doença de Parkinson, na base de dados bibliográficos PubMed, escritos em inglês. Os termos de pesquisa utilizados foram “Diabetes type 2” e “Parkinson disease”.
Resultados: Foram identificados 91 artigos, dos quais 80 foram excluídos por não serem relevantes para o tema. Foram ainda seleccionados 6 artigos adicionais com base em referências citadas nos artigos seleccionados anteriormente. Assim, foram seleccionados 17 artigos, 16 estudos originais e 1 meta-análise. De entre os estudos seleccionados, 13 estudos demonstraram uma associação entre diabetes mellitus e doença de Parkinson, enquanto 4 estudos não demonstraram esta associação.
Discussão: A associação entre as duas doenças parece acontecer através de factores genéticos, alterações mitocondriais, distúrbios na conformação de proteínas, stress oxidativo e neuroinflamação.
Conclusão: O estudo das vias metabólicas envolvidas nas duas patologias tem permitido compreender melhor os mecanismos que explicam os resultados dos estudos epidemiológicos. Como tal, a fisiopatologia das doenças implicadas ficará melhor estudada, o que permitirá pesquisar novas abordagens terapêuticas que podem vir a dar resposta às dificuldades encontradas neste campo, especialmente no caso da doença de Parkinson.
Introduction: Type 2 diabetes and Parkinson's disease are among the most prevalent diseases in the aging population. Several epidemiological studies have analyzed the role of diabetes in the development of Parkinson's disease and most have concluded that there is a positive association between the two diseases. The aim of this study was to systematize the existing knowledge about the epidemiological studies that evaluate the association between type 2 diabetes and Parkinson's disease and to advance possible biological explanations for this association. Methods: A review was made based on the collection of articles that study the association between type 2 diabetes and Parkinson's disease, in the literature databse PubMed, written in English. The search terms used were "Type 2 Diabetes" and "Parkinson's Disease". Results: A total of 91 articles were identified, of which 80 were excluded because they were not relevant to the theme. Further articles were selected based on references cited in the previously selected articles. Thus, 17 papers, 16 original studies and 1 meta-analysis, were selected. Of the studies selected, 13 studies demonstrated an association between diabetes and Parkinson's disease, while 4 studies did not demonstrate this association. Discussion: The association between the two diseases appears to occur through genetic factors, mitochondrial alterations, protein conformation disorders, oxidative stress and neurologic inflammation. Conclusion: The study of the metabolic pathways involved in the two diseases has allowed a better understanding of the mechanisms that explain the results of the epidemiological studies. As such, the pathophysiology of the diseases implicated will be better studied, which will allow to investigate new therapeutic approaches that can answer the difficulties found in this field, especially in the case of Parkinson's disease.
Introduction: Type 2 diabetes and Parkinson's disease are among the most prevalent diseases in the aging population. Several epidemiological studies have analyzed the role of diabetes in the development of Parkinson's disease and most have concluded that there is a positive association between the two diseases. The aim of this study was to systematize the existing knowledge about the epidemiological studies that evaluate the association between type 2 diabetes and Parkinson's disease and to advance possible biological explanations for this association. Methods: A review was made based on the collection of articles that study the association between type 2 diabetes and Parkinson's disease, in the literature databse PubMed, written in English. The search terms used were "Type 2 Diabetes" and "Parkinson's Disease". Results: A total of 91 articles were identified, of which 80 were excluded because they were not relevant to the theme. Further articles were selected based on references cited in the previously selected articles. Thus, 17 papers, 16 original studies and 1 meta-analysis, were selected. Of the studies selected, 13 studies demonstrated an association between diabetes and Parkinson's disease, while 4 studies did not demonstrate this association. Discussion: The association between the two diseases appears to occur through genetic factors, mitochondrial alterations, protein conformation disorders, oxidative stress and neurologic inflammation. Conclusion: The study of the metabolic pathways involved in the two diseases has allowed a better understanding of the mechanisms that explain the results of the epidemiological studies. As such, the pathophysiology of the diseases implicated will be better studied, which will allow to investigate new therapeutic approaches that can answer the difficulties found in this field, especially in the case of Parkinson's disease.
Description
Keywords
Diabetes Tipo 2 Doença de Parkinson Endocrinologia Neurologia