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Advisor(s)
Abstract(s)
Introdução: A hemoadsorção é uma técnica de circulação extracorporal (TCE) que
permite a passagem de sangue através de um cartucho contendo materiais adsorventes
por um período suficiente para possibilitar a remoção de solutos alvo com a menor
ativação do sistema imunitário. Desta forma, torna-se possível a remoção da corrente
sanguínea de substâncias tóxicas específicas, sem alteração dos restantes componentes
hemáticos necessários e protetores.
Objetivos: O objetivo primário deste trabalho é avaliar as potencialidades terapêuticas
da técnica de hemoadsorção, bem como os riscos associados à sua utilização. Pretendese, neste sentido, descrever sucintamente a técnica e as patologias que potencialmente
beneficiariam desta depuração.
Materiais e métodos: A informação utilizada na presente revisão da literatura foi
recolhida de livros e artigos obtidos por pesquisa na PubMed®, em inglês. Apenas foram
incluídos artigos publicados na última década, cujo conteúdo fosse correspondido a
indivíduos adultos.
Resultados: A hemoadsorção tem uma história longa e imperfeita, no entanto, recentes
avanços tecnológicos relacionados com a produção e revestimento aumentaram a
biocompatibilidade dos materiais adsorventes e reacenderam o interesse na sua
utilização. Atualmente, apesar de não existirem indicações formais para a instituição da
técnica de hemoadsorção, tem surgido a sua aplicação perante quadros de: intoxicação,
insuficiência hepática severa, sépsis e doença renal crónica.
Conclusão: Existe um novo interesse na hemoadsorção, serão precisos mais estudos
que demonstrem a eficácia desta técnica depurativa nas diferentes patologias, a
segurança da mesma e a forma de utilização e prescrição.
Introduction: Haemoadsorption is an extracorporeal circulation (ECT) technique in which blood is passed through a cartridge containing adsorbent materials for a period of time sufficient to enable the removal of target solutes with minimal activation of the immune system. In this way, it is possible to remove specific toxic substances from the bloodstream without altering the other necessary and protective haematological components. Objectives: The primary objective of this study is to evaluate the therapeutic potential of the haemoadsorption technique, and the risks associated with its use. The aim is to briefly describe the technique and the pathologies that could potentially benefit from this purification. Methodology: The information used in this review was obtained from books and articles by searching PubMed® in English. Only articles published in the last ten years and with content relevant to adults were included. Development: Haemoadsorption has a long and imperfect history, but recent technological advances in production and coating have improved the biocompatibility of adsorbent materials and revived interest in their use. Although there are currently no formal indications for the use of haemoperfusion, it has been used in cases of poisoning, severe liver failure, sepsis and chronic kidney disease. Conclusion: There is renewed interest in haemoadsorption, but more studies are needed to demonstrate the efficacy of this purification technique in different pathologies, its safety and how it should be used and prescribed.
Introduction: Haemoadsorption is an extracorporeal circulation (ECT) technique in which blood is passed through a cartridge containing adsorbent materials for a period of time sufficient to enable the removal of target solutes with minimal activation of the immune system. In this way, it is possible to remove specific toxic substances from the bloodstream without altering the other necessary and protective haematological components. Objectives: The primary objective of this study is to evaluate the therapeutic potential of the haemoadsorption technique, and the risks associated with its use. The aim is to briefly describe the technique and the pathologies that could potentially benefit from this purification. Methodology: The information used in this review was obtained from books and articles by searching PubMed® in English. Only articles published in the last ten years and with content relevant to adults were included. Development: Haemoadsorption has a long and imperfect history, but recent technological advances in production and coating have improved the biocompatibility of adsorbent materials and revived interest in their use. Although there are currently no formal indications for the use of haemoperfusion, it has been used in cases of poisoning, severe liver failure, sepsis and chronic kidney disease. Conclusion: There is renewed interest in haemoadsorption, but more studies are needed to demonstrate the efficacy of this purification technique in different pathologies, its safety and how it should be used and prescribed.
Description
Keywords
Circulação
Extracorporeal Doença Renal Endotoxinas Hemoadsorção Hemoperfusão Insuficiência Hepática Intoxicação Sepsis