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Abstract(s)
Introdução: A investigação de métodos que permitam um melhor e mais adequado controlo da dor crónica tem assumido cada vez mais relevância. Atualmente o controlo da dor crónica não oncológica assenta sobretudo em fisioterapia, medicação analgésica ou em técnicas invasivas. A medicina regenerativa é uma área emergente que oferece agora novas soluções para a redução da dor e aumento da funcionalidade destes doentes.
O conhecimento, cada vez mais aprofundado, da fisiopatologia subjacente às principais causas de dor crónica não oncológica tem sido fulcral para o desenvolvimento de terapias avançadas. Estas subdividem-se em terapias celulares, de indução celular e em técnicas derivadas da engenharia de tecidos. Pretende-se com estas técnicas de medicina regenerativa não só uma analgesia mais eficaz, mas também a modificação do curso natural da doença, com regressão do processo degenerativo.
Objetivos: 1- Identificar o potencial terapêutico na dor crónica não oncológica de técnicas avançadas de medicina regenerativa; 2- Identificar o estado da arte nas terapias avançadas (indução celular, terapia celular e engenharia de tecidos) para o tratamento da dor crónica; 3- Caracterizar a eficácia das terapias regenerativas no controlo da dor crónica não oncológica.
Metodologias: Para responder a estes objetivos foi feita uma pesquisa alargada de literatura sobre o tema, privilegiando-se a informação mais recente e usando como principais palavras-chave: “Dor crónica não oncológica”; “Dor neuropática”, “Dor osteoarticular”; “Dor musculo-tendinosa”; “Terapia Celular”; “Engenharia de Tecidos”; “Medicina Regenerativa” e “Células estaminais”.
Introduction: The research of new methods that allow a better control of chronic pain has has assumed more and more relevance over the past years. Currently, the control of non-oncologic chronic pain is based upon the management of physiotherapy, analgesic medication and invasive techniques. Regenerative medicine is an emerging area that offers new options in order to reduce pain and increase functionality of these patients. The increasing understanding of the mechanisms behind the main causes of non-oncologic chronic pain has been essential for the development of advanced therapies. These can be divided into celullar therapies, celullar induction therapies and also tissue-engineering derived techniques. The goal with these procedures is to attain not only a more effective analgesia but to change the natural course of the disease, by reversing the degenerative process. Objectives: 1- Identify the therapeutic potential of advanced regenerative medicine techniques, and their application in non-oncologic chronic pain; 2- Identify the State of the Art in advanced therapies (celular induction, celular therapy and tissue-engineering) for treatment of chronic pain; 3 – Distinguish the efficacy of regenerative therapies in the control of non oncologic chronic pain. Materials and Methods: In order to fulfill these objectives, a broad research of scientific literature was underwent, with more recent information having been favoured, whilst using the following key-words: “Non-oncologic chronic pain”, “neuropathic pain”; “Osteoarticular pain”; “Musculotendinous pain”; “Celullar Therapy”; “Tissue Engineering”; “Regenerative Medicine” and “Stem Cells”.
Introduction: The research of new methods that allow a better control of chronic pain has has assumed more and more relevance over the past years. Currently, the control of non-oncologic chronic pain is based upon the management of physiotherapy, analgesic medication and invasive techniques. Regenerative medicine is an emerging area that offers new options in order to reduce pain and increase functionality of these patients. The increasing understanding of the mechanisms behind the main causes of non-oncologic chronic pain has been essential for the development of advanced therapies. These can be divided into celullar therapies, celullar induction therapies and also tissue-engineering derived techniques. The goal with these procedures is to attain not only a more effective analgesia but to change the natural course of the disease, by reversing the degenerative process. Objectives: 1- Identify the therapeutic potential of advanced regenerative medicine techniques, and their application in non-oncologic chronic pain; 2- Identify the State of the Art in advanced therapies (celular induction, celular therapy and tissue-engineering) for treatment of chronic pain; 3 – Distinguish the efficacy of regenerative therapies in the control of non oncologic chronic pain. Materials and Methods: In order to fulfill these objectives, a broad research of scientific literature was underwent, with more recent information having been favoured, whilst using the following key-words: “Non-oncologic chronic pain”, “neuropathic pain”; “Osteoarticular pain”; “Musculotendinous pain”; “Celullar Therapy”; “Tissue Engineering”; “Regenerative Medicine” and “Stem Cells”.
Description
Keywords
Células Estaminais Dor Crónica Não Oncológica Engenharia de Tecidos Medicina Regenerativa Terapias Avançadas