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Authors
Abstract(s)
A Artrite Reumatóide (AR) é uma doença sistémica inflamatória, imunomediada
e de evolução crónica. A inflamação sinovial que a caracteriza acomete, geralmente,
múltiplas articulações e pode conduzir a destruição articular e perda de capacidade
funcional, causando uma redução significativa na qualidade de vida dos doentes.
Um diagnóstico e tratamento precoces são cruciais na prevenção da progressão
da AR, estando associados a um melhor prognóstico a longo prazo. Atualmente, uma das
terapêuticas mais promissoras são os fármacos biotecnológicos capazes de induzir
remissão da doença. Porém, a determinação de remissão, baseada na avaliação clínica e
laboratorial, tem-se mostrado insuficiente. Têm sido encontradas disparidades entre a
melhoria do estado clínico dos doentes e a progressão da AR, havendo evidência
ecográfica de lesão articular subclínica ativa em doentes em aparente remissão clínica.
Assim, esta dissertação consiste numa revisão de literatura sobre a avaliação da
resposta à terapêutica com anti-TNF-??, em doentes com AR, tendo por base a análise
dos achados clínicos e ecográficos, com o propósito de compreender qual o método de
avaliação mais fidedigno.
Rheumatoid Arthritis (RA) is an inflammatory, immune-mediated systemic disease with a chronic course. The synovial inflammation that characterizes it usually affects multiple joints and can lead to joint destruction and loss of functional capacity, causing a significant reduction in the quality of life of patients. Early diagnosis and treatment are crucial in preventing RA progression, being associated with a better long-term prognosis. Currently, one of the most promising therapies are the biotechnological drugs which can induce disease remission. However, the determination of remission, based on clinical and laboratory evaluation, has been shown to be insufficient. There have been disparities found between the improvement of the patients' clinical status and the progression of RA, with ultrasonographic evidence of subclinical active joint damage in patients in apparent clinical remission. Thus, this literature review focus on the evaluation of the therapeutic response with anti-TNF-a, in patients with RA, based on the analysis of clinical and ultrasound findings, with the purpose of understanding which method is most reliable.
Rheumatoid Arthritis (RA) is an inflammatory, immune-mediated systemic disease with a chronic course. The synovial inflammation that characterizes it usually affects multiple joints and can lead to joint destruction and loss of functional capacity, causing a significant reduction in the quality of life of patients. Early diagnosis and treatment are crucial in preventing RA progression, being associated with a better long-term prognosis. Currently, one of the most promising therapies are the biotechnological drugs which can induce disease remission. However, the determination of remission, based on clinical and laboratory evaluation, has been shown to be insufficient. There have been disparities found between the improvement of the patients' clinical status and the progression of RA, with ultrasonographic evidence of subclinical active joint damage in patients in apparent clinical remission. Thus, this literature review focus on the evaluation of the therapeutic response with anti-TNF-a, in patients with RA, based on the analysis of clinical and ultrasound findings, with the purpose of understanding which method is most reliable.
Description
Keywords
Anti-Tnf-?? Artrite Reumatóide Ecografia Remissão Resposta Terapêutica