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Authors
Abstract(s)
Os antimicrobianos exercem um papel fundamental na prevenção e tratamento de infeções,
mas a sua prescrição excessiva contribui para o aparecimento de microrganismos resistentes. A
resistência das bactérias aos antimicrobianos constitui uma grande preocupação para a
sociedade atual porque se estende a quase todos os antimicrobianos disponíveis, reduzindo as
terapêuticas alternativas e aumentando os custos do sistema de saúde. Estima-se que estas
resistências terão um custo anual em todo o mundo de 105 biliões de dólares e de acordo com
o Centro Europeu de Prevenção e Controlo de Doenças (ECDC) serão responsáveis pela morte
de 25000 pessoas a cada ano na Europa.
Os antibióticos mais prescritos e utilizados na prática clínica são os betalactâmicos, de que
fazem parte os carbapenemos. Estes antibióticos representam a última linha no tratamento de
infeções por bactérias multirresistentes, por isso a rápida emergência da sua resistência
constitui uma preocupação para os serviços de saúde e públicos.
O presente estudo teve como objetivo a avaliação dos perfis fenotípicos de resistência a todos
os antibióticos testados em estirpes produtoras de carbapenemases, bem como os produtos,
onde foram isolados na Unidade Local de Saúde (ULS) da Guarda, de forma a conhecer a
epidemiologia local (estudo de distribuição e dos fatores condicionantes e determinantes).
The antimicrobials play an important role preventing and treating infections, but its excessive prescription contributes to microorganism resistance. Bacteria have become antimicrobials-resistant and that has arisen great concern among current society, because it includes almost all antimicrobials available, reducing the use of alternative therapeutic and increasing the costs of health system. Experts predict this resistance will cost 105 billion dollars a year and, according to the European Centre of Disease Prevention and Control (ECDC), it will be responsible for 25000 deaths each year in Europe. The most used and prescribed are betalactams antibiotics, which include carbapenem. They are usually reserved for multi-resistant bacterial infections, so the increasing rates of resistance are of great concern to public health system. This research was conducted to evaluate the phenotypic pattern of resistance including all carbapenem antibiotics tested and also to analyse the places where they were isolated in Local Health Unit (ULS) of Guarda, in order to be aware of the local epidemiology (a study of distribution and conditioning and determining factors)
The antimicrobials play an important role preventing and treating infections, but its excessive prescription contributes to microorganism resistance. Bacteria have become antimicrobials-resistant and that has arisen great concern among current society, because it includes almost all antimicrobials available, reducing the use of alternative therapeutic and increasing the costs of health system. Experts predict this resistance will cost 105 billion dollars a year and, according to the European Centre of Disease Prevention and Control (ECDC), it will be responsible for 25000 deaths each year in Europe. The most used and prescribed are betalactams antibiotics, which include carbapenem. They are usually reserved for multi-resistant bacterial infections, so the increasing rates of resistance are of great concern to public health system. This research was conducted to evaluate the phenotypic pattern of resistance including all carbapenem antibiotics tested and also to analyse the places where they were isolated in Local Health Unit (ULS) of Guarda, in order to be aware of the local epidemiology (a study of distribution and conditioning and determining factors)
Description
Keywords
Betalactâmicos Carbapenemases Carbapenemos Enterobacteriales