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Abstract(s)
Cerca de um terço das nossas vidas são passadas a dormir. O sono desempenha um papel
fundamental na manutenção da capacidade de resposta do corpo aos desafios impostos
durante a vigília.
Cada vez mais, a tendência na sociedade moderna é para a degradação da qualidade e
quantidade do sono, para a qual contribuem diversos factores psicossociais. Os médicos
podem contribuir para melhorar esta situação, e uma das formas de o fazerem é pela
adequação da prescrição farmacológica, utilizando a evidência científica atual para a escolha
do tipo de fármaco, da sua dose e da altura do dia em que é administrado, e para a remoção
ou substituição de medicamentos que possam estar a prejudicar o sono do doente.
Esta monografia pretende resumir a evidência atual sobre os efeitos fisiopatológicos de
fármacos que interferem na arquitetura do sono. Inclui a base fisiológica do sono e os efeitos
e mecanismos de ação dos seguintes fármacos: antidepressivos, antipsicóticos, hipnóticos,
anti-histamínicos, medicação cardiovascular, xantinas, fármacos ativadores e corticóides.
Tipo de Estudo: Monografia – Revisão Temática da Literatura Científica.
About one third of our lives is spent sleeping. Sleep has an essencial role in maintaining the ability of the body to answer the challenges imposed during wakefulness. There is a growing tendency for the degradation of sleep quality and quantity in modern society, influenced by several psicossocial factors. Doctors can contribute to improve this situation and one of the ways to do it is through optimization of the pharmacological prescription, using the current cientific evidence to choose the type of medication presribed, the appropriate dose and the timing of administration, and to remove or replace medications potencially affecting the patient’s sleep. The aim of this study was to review current evidence of the pathophysiological effects of the drugs that interfere with sleep architecture. It includes the physiological basis of sleep and the effects and mechanisms of action of the following medications: antidepressants, antipsychotics, hypnotics, antihistamines, anti-epileptic drugs, antiparkinsonics, cardiovascular medication, xantines, activating drugs and corticosteroids. Type of Study: Monograph – Thematic Review of Scientific Literature.
About one third of our lives is spent sleeping. Sleep has an essencial role in maintaining the ability of the body to answer the challenges imposed during wakefulness. There is a growing tendency for the degradation of sleep quality and quantity in modern society, influenced by several psicossocial factors. Doctors can contribute to improve this situation and one of the ways to do it is through optimization of the pharmacological prescription, using the current cientific evidence to choose the type of medication presribed, the appropriate dose and the timing of administration, and to remove or replace medications potencially affecting the patient’s sleep. The aim of this study was to review current evidence of the pathophysiological effects of the drugs that interfere with sleep architecture. It includes the physiological basis of sleep and the effects and mechanisms of action of the following medications: antidepressants, antipsychotics, hypnotics, antihistamines, anti-epileptic drugs, antiparkinsonics, cardiovascular medication, xantines, activating drugs and corticosteroids. Type of Study: Monograph – Thematic Review of Scientific Literature.
Description
Keywords
Arquitetura do Sono Efeitos Adversos. Insónia Medicações Sono Nrem Sono Rem Sonolência