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Abstract(s)
Este relatório de estágio engloba as três partes essenciais para o culminar da formação de um farmacêutico: um estágio em Farmácia Hospitalar e um estágio em Farmácia comunitária, essenciais para a consolidação de todos os conhecimentos desenvolvidos ao longo do curso, e o desenvolvimento de um trabalho de investigação, que possibilita uma ligação às intervenções farmacêuticas nesta área. Desta forma, este relatório encontra-se dividido em três capítulos.
O primeiro capítulo é relativo ao projeto de dissertação de mestrado que foi realizado com o intuito de identificar potenciais preocupações com a segurança de formulações vaginais semi-sólidas através da avaliação da sua osmolalidade, pH e capacidade tampão. O uso de produtos vaginais é muito comum, não apenas em situações de inflamação ou infeção, as quais não requerem um uso prolongado, mas também em algumas situações diárias que requerem lubrificação ou hidratação. Algumas características tecnológicas das formulações vaginais estão intimamente ligadas com questões de segurança e performance e a sua avaliação é da maior importância. No entanto, existe pouca informação sobre as propriedades tecnológicas dos produtos vaginais disponíveis. Neste trabalho foram analisados 19 produtos de aplicação vaginal, dos quais oito apresentaram osmolalidade superior ao recomendado. Entre os valores de pH encontrados três mostraram-se mais ácidos e dois mais básicos que os valores fisiológicos. A capacidade tampão encontrada foi também bastante variável não se encontrando forte relação entre este parâmetro e a indicação terapêutica / alegação do produto. Relativamente a citotoxicidade esta mostrou-se superior à citotoxicidade do N-9 em três dos produtos analisados. Assim, foi possível identificar potenciais questões de segurança entre os produtos vaginais comercialmente disponíveis que devem ser levadas em consideração, particularmente quando é requerido um uso prolongado.
No segundo capítulo encontra-se a descrição de todas as aprendizagens e experiências vivenciadas no estágio em Farmácia Hospitalar no Hospital Sousa Martins, que teve a duração total de 320 horas.
No terceiro capítulo encontra-se descrita a experiencia profissional adquirida através do estágio em Farmácia Comunitária na Farmácia Amorim, que se realizou por um período de 480 horas.
This traineeship report incorporates the three essential parts for a pharmacist’s formation: a traineeship in Hospital Pharmacy and a traineeship in a Community Pharmacy, essential for the consolidation of all the knowledge acquired through the studies, and the development of an investigation work, which enables a link to pharmaceutical interventions in this this area. Therefore this report is divided in three chapters. The first chapter is about the master’s dissertation project whose purpose was to identify potential safety issues of semi-solid vaginal formulations trough the assessment of its osmolality, pH and acid-buffering capacity. The use of vaginal products is very common, not only in inflammatory and infection situations, which usually do not require long term use, but also in some daily situations requiring lubrication or hydration. Some technological characteristics of vaginal formulations are intimately linked with safety and performance issues and their assessment is of the utmost importance. However, there is a lack of information on technological properties of commercially available vaginal products. In this work 19 vaginal products were analysed and eight of which presented higher osmolality than the recommended. Among pH values measured, three products were more acidic and two more basic than the physiological values. The buffer capacity was also found highly variable and was not found a strong relationship between this parameter and the therapeutic indication / product’s allegation. For three of the analysed products the cytotoxicity was superior to cytotoxicity of N-9 in. Therefore we could identify potential safety issues among commercially available vaginal products that should be taken into account particularly when long-term use is required. The second chapter describes the knowledge and experiences acquired in the traineeship in Hospital Pharmacy in Hospital Sousa Martins, throughout 320 hours. Finally, the third chapter describes the professional experience acquired through the traineeship in Community Pharmacy in Farmácia Amorim, which occurred in a period of 480 hours.
This traineeship report incorporates the three essential parts for a pharmacist’s formation: a traineeship in Hospital Pharmacy and a traineeship in a Community Pharmacy, essential for the consolidation of all the knowledge acquired through the studies, and the development of an investigation work, which enables a link to pharmaceutical interventions in this this area. Therefore this report is divided in three chapters. The first chapter is about the master’s dissertation project whose purpose was to identify potential safety issues of semi-solid vaginal formulations trough the assessment of its osmolality, pH and acid-buffering capacity. The use of vaginal products is very common, not only in inflammatory and infection situations, which usually do not require long term use, but also in some daily situations requiring lubrication or hydration. Some technological characteristics of vaginal formulations are intimately linked with safety and performance issues and their assessment is of the utmost importance. However, there is a lack of information on technological properties of commercially available vaginal products. In this work 19 vaginal products were analysed and eight of which presented higher osmolality than the recommended. Among pH values measured, three products were more acidic and two more basic than the physiological values. The buffer capacity was also found highly variable and was not found a strong relationship between this parameter and the therapeutic indication / product’s allegation. For three of the analysed products the cytotoxicity was superior to cytotoxicity of N-9 in. Therefore we could identify potential safety issues among commercially available vaginal products that should be taken into account particularly when long-term use is required. The second chapter describes the knowledge and experiences acquired in the traineeship in Hospital Pharmacy in Hospital Sousa Martins, throughout 320 hours. Finally, the third chapter describes the professional experience acquired through the traineeship in Community Pharmacy in Farmácia Amorim, which occurred in a period of 480 hours.
Description
Keywords
Aplicação Vaginal de Fármacos Capacidade Tampão Citotoxicidade Farmácia Comunitária Farmácia Hospitalar Osmolalidade Ph