| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 1.06 MB | Adobe PDF |
Authors
Abstract(s)
A Fibromialgia (FM) é uma doença crónica caracterizada por dor difusa associada a
elevados níveis de fadiga cuja intensidade é muito variável. Sintomas semelhantes são
encontrados em pacientes com baixos níveis de vitamina D, uma vitamina que se
comporta como uma hormona com múltiplos recetores espalhados em vários tecidos.
Embora o seu papel na fisiopatologia da fibromialgia permaneça obscuro, estudos
apontam para uma correlação entre a deficiência de vitamina D e a gravidade dos
sintomas da fibromialgia.
Portanto, realizámos uma revisão sistemática da literatura para determinar o valor da
suplementação de vitamina D na fibromialgia.
As bases de dados Medline, EMBASE e Cochrane foram pesquisadas, de dezembro de
2021 a janeiro de 2022, usando os descritores “Fibromialgia”, “Fadiga” e “Vitamina D”.
Foram selecionados ensaios clínicos randomizados e de controle incluindo pacientes
com fibromialgia nos quais a suplementação de vitamina D foi feita. Os dados incluíram
descrição sociodemográfica, critérios de diagnóstico, sintomas de fibromialgia,
Questionário de Impacto da Fibromialgia (FIQ), formulário curto de saúde de 36 itens
(SF36) e protocolo de suplementação de vitamina D.
Dos 2.480 artigos iniciais, 4 foram elegíveis para análise final. Num dos estudos não se
observou nenhuma melhora significativa do FIQ com a suplementação de vitamina D.
Os três restantes observaram melhorias significativas nas pontuações do SF-36 e FIQ,
mas em graus diferentes. Um demonstrou apenas melhorias em componentes específicos
do SF-36, demonstrando também melhorias em relação à fadiga matinal. Outro
demonstra melhoria em todos os parâmetros do SF-36, exceto no nível de dor. Por fim,
o último estudo observou melhoria em ambas as escalas.
A nossa revisão mostra resultados dissonantes sobre o papel do uso de suplementação
de vitamina D na melhoria da qualidade de vida dos doentes com fibromialgia.
Estes resultados podem ser explicados por diferentes protocolos de suplementação e
também por diferentes níveis basais de vitamina D para os quais se decidiu suplementar.
No entanto, a suplementação de vitamina D parece ter um benefício na fadiga e qualidade
de vida em pacientes com FM. Estudos maiores, com maior duração e com protocolo de suplementação mais uniforme, são necessários para confirmar os resultados desta
revisão.
Fibromyalgia is a chronic disease characterized by diffuse pain associated with high levels of fatigue whose intensity is very variable. Similar symptoms are found in patients with low levels of vitamin D, a vitamin that behaves like a hormone with multiple receptors spread in several tissues. Although its role in the pathophysiology of Fibromyalgia remains unclear, studies point to a correlation between vitamin D deficiency and Fibromyalgia symptoms severity. Therefore, we conduct a systematic review of the literature to determine the value of vitamin D supplementation in fibromyalgia. Medline, EMBASE, and Cochrane databases were searched, from December 2021 to January 2022, using the descriptors “Fibromyalgia”, “Fatigue” and “Vitamin D.” Randomized and clinical control trials including Fibromyalgia patients in whom supplementation of vitamin D was made were selected. Data comprised sociodemographic description, diagnosis criteria, fibromyalgia symptoms, Fibromyalgia Impact Questionnaire (FIQ), short-form 36 (SF36), and vitamin D supplementation protocol was collected. Of the initial 2480 articles, 4 were eligible for final analysis. One did not observe any significant improvement in FIQ scores with vitamin D supplementation. The remaining three observed significant improvements in SF-36 and FIQ scores but to different extents. One only demonstrated improvements in specific components of the SF-36, also demonstrating improvements concerning morning fatigue. Another shows improvements in all SF-36parameters, except for pain level. Lastly, other observed improvements in the scores of both FIQ and SF-36 scales. Our review exhibits conflicting results regarding the role of vitamin D supplementation in Fibromyalgia patient’s quality of life. These results can be explained by different supplementation protocols and also different baseline levels of vitamin D for which it was decided to supplement. Nevertheless, vitamin D supplementation appears to have a benefit in fatigue and quality of life in FM patients. Larger studies, which last longer and have a more uniform supplementation protocol, are needed to confirm the results of this review.
Fibromyalgia is a chronic disease characterized by diffuse pain associated with high levels of fatigue whose intensity is very variable. Similar symptoms are found in patients with low levels of vitamin D, a vitamin that behaves like a hormone with multiple receptors spread in several tissues. Although its role in the pathophysiology of Fibromyalgia remains unclear, studies point to a correlation between vitamin D deficiency and Fibromyalgia symptoms severity. Therefore, we conduct a systematic review of the literature to determine the value of vitamin D supplementation in fibromyalgia. Medline, EMBASE, and Cochrane databases were searched, from December 2021 to January 2022, using the descriptors “Fibromyalgia”, “Fatigue” and “Vitamin D.” Randomized and clinical control trials including Fibromyalgia patients in whom supplementation of vitamin D was made were selected. Data comprised sociodemographic description, diagnosis criteria, fibromyalgia symptoms, Fibromyalgia Impact Questionnaire (FIQ), short-form 36 (SF36), and vitamin D supplementation protocol was collected. Of the initial 2480 articles, 4 were eligible for final analysis. One did not observe any significant improvement in FIQ scores with vitamin D supplementation. The remaining three observed significant improvements in SF-36 and FIQ scores but to different extents. One only demonstrated improvements in specific components of the SF-36, also demonstrating improvements concerning morning fatigue. Another shows improvements in all SF-36parameters, except for pain level. Lastly, other observed improvements in the scores of both FIQ and SF-36 scales. Our review exhibits conflicting results regarding the role of vitamin D supplementation in Fibromyalgia patient’s quality of life. These results can be explained by different supplementation protocols and also different baseline levels of vitamin D for which it was decided to supplement. Nevertheless, vitamin D supplementation appears to have a benefit in fatigue and quality of life in FM patients. Larger studies, which last longer and have a more uniform supplementation protocol, are needed to confirm the results of this review.
Description
Keywords
Fadiga Fibromialgia Vitamina D