| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 934.75 KB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
Introdução: A Perturbação do Espetro do Autismo (PEA) é uma patologia do
neurodesenvolvimento, da qual faz parte um conjunto heterogéneo de quadros clínicos
com grande variabilidade na sua apresentação clínica, e da qual se destacam défices na
comunicação e interação social. A PEA pode acarretar assim impacto significativo
quotidiano, incluindo na vida familiar, escolar e profissional. Com vista a refletir sobre a
melhoria de cuidados médicos, justifica-se sobejamente aprofundar terapêuticas que
promovam a melhoria clínica no neurodesenvolvimento, nomeadamente no
comportamento e maior disponibilidade para a socialização. Cada vez mais é discutida a
relação bidirecional do eixo cérebro-intestino e a sua influência adjuvante na terapêutica
em vários quadros psicopatológicos, tais como na ansiedade, depressão,
hiperatividade/défice de atenção, e também na PEA, entre outros.
Objetivos: Esta dissertação tem por objetivo estudar as alterações do eixo cérebrointestino na PEA, novas terapêuticas nesta área, assim como refletir sobre o impacto da
alteração da microbiota intestinal na terapêutica com probióticos
Metodologia: Foi feita uma pesquisa sobre os tópicos PEA, microbioma, eixo cérebrointestino e probióticos na PubMed, B-on e EBSCO. Esta foi completada em Dezembro de
2023. Foram selecionados 10 estudos de um total inicial de 159 artigos. A informação
recolhida diz respeito aos participantes, caraterísticas do estudo, métodos de análise e
principais resultados. Adicionalmente foram lidos e incluídos artigos pertinentes à
construção desta revisão literária. No final da análise dos estudos e da avaliação dos
resultados considerados, procedeu-se à síntese narrativa dos achados encontrados.
Resultados: Dos 85 artigos inicialmente apurados, foram selecionados 10 estudos.
Embora tenham sido relatados resultados em diferentes campos, os estudos
apresentaram consenso a nível das conclusões obtidas, nomeadamente no que diz
respeito à sintomatologia GI e comportamental.
Conclusão: Os estudos analisados suportam a existência de benefício na melhoria de
sintomas GIs e comportamentais assim como melhoria nos padrões inflamatórios
intestinais e microbiota através da toma de probióticos.
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental pathology, which includes a heterogeneous set of clinical conditions with great variability in its clinical presentation and which highlights deficits in communication and social interaction. ASD can therefore have a significant impact on daily life, including family, school, and professional life. With the goal of reflecting on the improvement of medical care, it is highly justified to delve deeper into therapies that promote clinical improvement in neurodevelopment, particularly in behavior and greater availability for socialization. The bidirectional relationship between the brain-gut axis and its adjuvant influence in therapy in various psychopathological conditions such as anxiety, depression, hyperactivity/attention deficit, and ASD, among others, is increasingly being discussed. Objectives: This dissertation aims to study changes in the brain-gut axis in ASD, new therapies in this area, as well as reflect on the impact of probiotic therapy in changes in the intestinal microbiota. Methodology: A search was done on the topics of ASD, microbiome, brain-gut axis and probiotics in PubMed, B-on and EBSCO. This was completed in December 2023. 10 studies were selected from an initial total of 159 articles. The information collected concerns participants, study characteristics, analysis methods and main results. In addition, articles that are relevant to the construction of this review were read and included. At the end of the analysis of the studies and the evaluation of the results considered, it was made a synthesis of the results found. Results: Of the 85 articles initially investigated, 10 studies were selected. Although results have been reported in different fields, studies have reached consensus on their conclusions, particularly regarding the gastrointestinal tract and behavioural symptoms.
Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental pathology, which includes a heterogeneous set of clinical conditions with great variability in its clinical presentation and which highlights deficits in communication and social interaction. ASD can therefore have a significant impact on daily life, including family, school, and professional life. With the goal of reflecting on the improvement of medical care, it is highly justified to delve deeper into therapies that promote clinical improvement in neurodevelopment, particularly in behavior and greater availability for socialization. The bidirectional relationship between the brain-gut axis and its adjuvant influence in therapy in various psychopathological conditions such as anxiety, depression, hyperactivity/attention deficit, and ASD, among others, is increasingly being discussed. Objectives: This dissertation aims to study changes in the brain-gut axis in ASD, new therapies in this area, as well as reflect on the impact of probiotic therapy in changes in the intestinal microbiota. Methodology: A search was done on the topics of ASD, microbiome, brain-gut axis and probiotics in PubMed, B-on and EBSCO. This was completed in December 2023. 10 studies were selected from an initial total of 159 articles. The information collected concerns participants, study characteristics, analysis methods and main results. In addition, articles that are relevant to the construction of this review were read and included. At the end of the analysis of the studies and the evaluation of the results considered, it was made a synthesis of the results found. Results: Of the 85 articles initially investigated, 10 studies were selected. Although results have been reported in different fields, studies have reached consensus on their conclusions, particularly regarding the gastrointestinal tract and behavioural symptoms.
Description
Keywords
Crianças Microbioma Perturbação do Espetro do Autismo Probiótico Psiquiatria da Infância e Adolescência