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Abstract(s)
A presente dissertação de mestrado, realizada no âmbito da unidade curricular Estágio
do Mestrado Integrado em Ciências Farmacêuticas, encontra-se dividida em três
capítulos correspondentes às componentes de investigação e estágios curriculares
realizados em Farmácia Hospitalar e Comunitária.
O primeiro capítulo, intitulado “Estudo dos efeitos dos aditivos di(2-etilhexil) ftalato e
metilparabeno em astrócitos corticais”, diz respeito ao trabalho de investigação
laboratorial levado a cabo no Centro de Investigação em Ciências da Saúde da
Universidade da Beira Interior. Os compostos alvo do estudo consistem em duas
substâncias incluídas na formulação de múltiplos produtos, que são diariamente
utilizados pela população em geral. Apesar do seu longo historial de aplicação, até ao
momento e de que se tenha conhecimento, parecem ainda existir zonas cinzentas
relativamente à sua toxicidade, em particular à sua neurotoxicidade, nomeadamente,
em astrócitos, o que justifica a concretização do presente trabalho. Assim, procurou-se
avaliar os efeitos da exposição às substâncias mencionadas em termos de viabilidade
celular, assim como ao nível de alterações de reatividade glial induzidas pelos
tratamentos efetuados. Deste modo, foi possível concluir que, tanto di(2-etilhexil)
ftalato como metilparabeno, exercem efeitos em astrócitos, sumarizados nos seguintes
pontos: di(2-etilhexil) ftalato encontra-se na origem de proliferação celular de
astrócitos, ao passo que metilparabeno provoca a morte celular; e ambas as moléculas
demonstraram conduzir a um estado de reatividade astrocitária. Não obstante,
atendendo às limitações presentes, revela-se imperativo realizar estudos futuros
complementares, no sentido de melhor compreender e aprofundar com maior robustez
os efeitos provocados pelos compostos.
O segundo capítulo deste documento inclui o resumo da experiência profissionalizante
em Farmácia Hospitalar. Nesta secção apresenta-se uma descrição intensiva dos
Serviços Farmacêuticos do Centro Hospitalar Universitário Cova da Beira, E.P.E., das
várias etapas do circuito dos medicamentos e outros produtos de saúde e ainda uma
abordagem às inúmeras vertentes do farmacêutico hospitalar.
O terceiro e último capítulo diz respeito ao mesmo tipo de conteúdo incluído no
anterior, direcionando-se, contudo, para a valência de Farmácia Comunitária,
abordando tópicos como: descrição da Farmácia Sant’Ana, componente técnicocientífica associada, etapas do circuito dos medicamentos e outros produtos de saúde, serviços farmacêuticos e outros serviços de promoção da saúde e bem-estar prestados e
contabilidade e gestão inerentes.
This master's thesis, carried out in the scope of the curricular unit Internship of the Integrated Master's Degree in Pharmaceutical Sciences, is divided into three chapters corresponding to the research components and curricular internships carried out in Hospital and Community Pharmacy. The first chapter, entitled "Study of the effects of the additives di(2-ethylhexyl) phthalate and methylparaben in cortical astrocytes", concerns the laboratory research work conducted at the Center for Health Sciences Research at the University of Beira Interior. The target compounds of the study consist of two substances included in the formulation of multiple products, which are used daily by the general population. Despite their long history of application, until now and to our knowledge, there still seem to exist grey areas regarding their toxicity, in particular, their neurotoxicity, namely, in astrocytes, which justifies the present work. Thus, we sought to evaluate the effects of exposure to the substances mentioned in terms of cell viability and glial reactivity. Thus, it was possible to conclude that both di(2-ethylhexyl) phthalate and methylparaben exert effects on astrocytes, summarized in the following points: di(2- ethylhexyl) phthalate is at the origin of cell proliferation of astrocytes, while methylparaben causes cell death; and both molecules have been shown to lead to a state of astrocyte reactivity. Nevertheless, given the present limitations, it is imperative to conduct further studies in the future in order to better understand and further robustly investigate the effects caused by the compounds. The second chapter of this document includes a summary of the professional experience in Hospital Pharmacy. This section presents an intensive description of the Pharmaceutical Services of the University Hospital Center of Cova da Beira, E.P.E., of the various stages of the circuit of medical drugs and other health products and an approach to the numerous aspects of the hospital pharmacist. The third and last chapter is related to the same type of content included in the previous one. However, it is directed to the Community Pharmacy service, addressing topics such as a description of Sant'Ana Pharmacy, technical and scientific components, steps of the circuit of medical drugs and other health products, pharmaceutical services, and other health promotion and welfare services provided, and inherent accounting and management.
This master's thesis, carried out in the scope of the curricular unit Internship of the Integrated Master's Degree in Pharmaceutical Sciences, is divided into three chapters corresponding to the research components and curricular internships carried out in Hospital and Community Pharmacy. The first chapter, entitled "Study of the effects of the additives di(2-ethylhexyl) phthalate and methylparaben in cortical astrocytes", concerns the laboratory research work conducted at the Center for Health Sciences Research at the University of Beira Interior. The target compounds of the study consist of two substances included in the formulation of multiple products, which are used daily by the general population. Despite their long history of application, until now and to our knowledge, there still seem to exist grey areas regarding their toxicity, in particular, their neurotoxicity, namely, in astrocytes, which justifies the present work. Thus, we sought to evaluate the effects of exposure to the substances mentioned in terms of cell viability and glial reactivity. Thus, it was possible to conclude that both di(2-ethylhexyl) phthalate and methylparaben exert effects on astrocytes, summarized in the following points: di(2- ethylhexyl) phthalate is at the origin of cell proliferation of astrocytes, while methylparaben causes cell death; and both molecules have been shown to lead to a state of astrocyte reactivity. Nevertheless, given the present limitations, it is imperative to conduct further studies in the future in order to better understand and further robustly investigate the effects caused by the compounds. The second chapter of this document includes a summary of the professional experience in Hospital Pharmacy. This section presents an intensive description of the Pharmaceutical Services of the University Hospital Center of Cova da Beira, E.P.E., of the various stages of the circuit of medical drugs and other health products and an approach to the numerous aspects of the hospital pharmacist. The third and last chapter is related to the same type of content included in the previous one. However, it is directed to the Community Pharmacy service, addressing topics such as a description of Sant'Ana Pharmacy, technical and scientific components, steps of the circuit of medical drugs and other health products, pharmaceutical services, and other health promotion and welfare services provided, and inherent accounting and management.
Description
Keywords
Astrócitos Di(2-Etilhexil) Ftalato Farmácia Comunitária Farmácia Hospitalar Metilparabeno