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Authors
Abstract(s)
Em ambiente hospitalar a contaminação de superfícies, tais como os manipulos das
portas e os carrinhos operacionais hospitalares, podem ocorrer por manuseamento,
derramamento de soluções não estéreis ou através de aerossóis, sendo este um potencial
modo de transmissão de infeções.
As infeções originadas por bactérias têm sido uma das principais preocupações de saúde
ao longo da história humana. Após o desenvolvimento de antibióticos, surgiu a convicção de
que o problema das infeções bacterianas teria os dias contados. Contudo, os agentes
patogénicos evoluíram sofisticados mecanismos de resistência aos antibióticos. Essa
resistência antimicrobiana é um dos desafios mais significativos para a saúde humana nos dias
de hoje.
Com a escassez de novos antibióticos no mercado, a necessidade de medidas para
evitar uma crise global na área da saúde é cada vez mais urgente. Dessa forma, os
revestimentos antibacterianos tornaram-se um campo de pesquisa muito ativo e fortemente
estimulado pela crescente urgência de identificar alternativas à administração tradicional de
antibióticos.
Nesta dissertação o objetivo consistiu em adquirir um conhecimento abrangente sobre
revestimentos antimicrobianos já existentes e uma posterior investigação de um revestimento
inovador com propriedades antimicrobianas à base de nanoparticulas de cobre imobilizado em
nanofibras de policaprolactona (PCL) obtidas através da técnica de electrospinning.
In hospital environment, the contamination of surfaces, such as door handles and hospital operating trolleys, may occur through handling, spillage of non-sterile solutions or through aerosols, thus being a potential mode of transmission of infections. Infections caused by bacteria have been a major health concern throughout human history. After the discovery of antibiotics, the conviction that the problem of bacterial infections would have their last days arose. However, pathogens have evolved sophisticated drug resistance mechanisms. This antimicrobial resistance is one of the most significant challenges to human health today. With the shortage of new antibiotics on the market, the need for measures to prevent a global health crisis is increasingly urgent. Thus, antibacterial coatings have become a very active field of research and strongly stimulated by the increasing urgency of identifying alternatives to the traditional administration of antibiotics. In this dissertation the objective was to acquire a comprehensive knowledge about existing antimicrobial coatings and a subsequent investigation of an innovative coating with antimicrobial properties based on nanoparticles immobilized on polycaprolactone nanofibres (PCL) obtained through the electrospinning technique.
In hospital environment, the contamination of surfaces, such as door handles and hospital operating trolleys, may occur through handling, spillage of non-sterile solutions or through aerosols, thus being a potential mode of transmission of infections. Infections caused by bacteria have been a major health concern throughout human history. After the discovery of antibiotics, the conviction that the problem of bacterial infections would have their last days arose. However, pathogens have evolved sophisticated drug resistance mechanisms. This antimicrobial resistance is one of the most significant challenges to human health today. With the shortage of new antibiotics on the market, the need for measures to prevent a global health crisis is increasingly urgent. Thus, antibacterial coatings have become a very active field of research and strongly stimulated by the increasing urgency of identifying alternatives to the traditional administration of antibiotics. In this dissertation the objective was to acquire a comprehensive knowledge about existing antimicrobial coatings and a subsequent investigation of an innovative coating with antimicrobial properties based on nanoparticles immobilized on polycaprolactone nanofibres (PCL) obtained through the electrospinning technique.
Description
Keywords
Cobre Electrospinning Pseudomonas Aeruginosa Revestimentos Antimicrobianos Staphylococcus Aureus