| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 757.77 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Introdução: A Esclerose MĂșltipla Ă© um dos distĂșrbios neurolĂłgicos mais comuns. Em muitos paĂses Ă© a principal causa de incapacidade nĂŁo traumĂĄtica em adultos jovens. Trata-se de uma doença autoimune do Sistema Nervoso Central, caraterizada por inflamação crĂłnica, desmielinização, gliose e perda neuronal. Ă aproximadamente trĂȘs vezes mais comum em indivĂduos do sexo feminino em relação aos do sexo masculino. A idade no inĂcio da doença tipicamente situa-se entre os 20 e os 40 anos. No entanto, em cerca de 10 % dos casos, esta ocorre antes dos 18 anos e numa pequena percentagem antes dos 10 anos. Quando a esclerose mĂșltipla surge depois dos 50 anos, Ă© denominada esclerose mĂșltipla de inĂcio tardio, ocorrendo em cerca de 5% da população
Metodologia: foi feito um estudo observacional transversal usando a base de dados iMedÂź do Centro Hospitalar Cova da Beira.
Resultados: a amostra Ă© composta de 108 doentes, sendo que 77 sĂŁo do sexo feminino e 31 do sexo masculino, com idade compreendida entre os 19 e os 82 anos, e com mĂ©dia situada nos 48,35 anos. Encontrou-se uma maior prevalĂȘncia da doença no sexo feminino com uma relação mulher/homem de 2,48:1. A mĂ©dia da idade aquando do inĂcio da doença Ă© ligeiramente superior no sexo masculino (36,18) em relação ao feminino (33,97). Estas nĂŁo sĂŁo significativamente diferentes (p=0,354). Os sintomas inaugurais mais prevalentes nesta população sĂŁo os distĂșrbios motores (40,7%) e visuais (33,3%). Quanto ao curso da doença 70,4% dos nossos doentes possuem EMSR, 14,8% EMSP, 6,5% EMPP e 1,9% EMPR. A Expanded Disability Status Scale nesta população tem valores compreendidos entre 0 e 9 com mĂ©dia de 2,091. Doentes que tiveram um curso progressivo inaugural tĂȘm a mĂ©dia da idade no inĂcio da doença significativamente superior (p=0,00215) aos que nĂŁo tiveram. Embora 9 dos nossos doentes tiveram esclerose mĂșltipla de inicio tardio, apenas 2 tiveram progressĂŁo de inĂcio.
ConclusĂŁo: conclui-se que as caracterĂsticas da nossa população e as variĂĄveis em estudo nĂŁo sĂŁo muito diferentes daquelas observadas em estudos internacionais. A exceção a essa generalização Ă© a maior frequĂȘncia de esclerose mĂșltipla de inĂcio tardio em comparação com outros estudos internacionais.
Background: Multiple sclerosis is one of the worldâs most common neurological disorders. In many countries, it is the leading cause of non-traumatic disability in young adults. It is an autoimmune disease of the Central Nervous System characterized by chronic inflammation, demyelination, gliosis, and neuronal loss. The disease is approximately threefold more common in women than men. The age of onset is typically between 20 and 40 years. Approximately 10% of cases begin before age18 years of age, and a small percentage of cases begin before the age of 10 years. While multiple sclerosis onset after the age of 50, termed late-onset multiple sclerosis occurs in approximately 5% of the population. Methodology: We conducted this cross-sectional observational study using medical records on iMedÂź data base of Centro Hospitalar Cova da Beira. Results: The sample is composed by 108 patients, 77 women and 31 men. The age range was between 19 and 82 years, with mean in 48,35 years. We found a higher prevalence of the disease in women with a woman /man ratio of 2.48: 1. The mean age at the onset of the disease is slightly higher in males (36.18) compared to females (33,97). These are not significantly different between the two groups (p = 0.354). The first most commons symptoms in this population are motor (40,7%) and visual (33.3%) disturbances. As for the course of the disease 70.4% of our patients have RRMS, 14.8% SPMS, 6.5% PPMS and PRMS 1.9%. The Expanded Disability Status Scale in this population have values between 0 and 9 with a mean of 2,091. Patients who had an inaugural progressive course have the average age at onset of disease significantly higher (p= 0.00215) to those who had not. Although 9 of our patients had late onset multiple sclerosis, only 2 had early progression. Conclusion: It is concluded that the characteristics of our population and the variables studied are not very different from those observed in international studies. The exception to this generalization is the highest frequency of EMIT compared to other international studies.
Background: Multiple sclerosis is one of the worldâs most common neurological disorders. In many countries, it is the leading cause of non-traumatic disability in young adults. It is an autoimmune disease of the Central Nervous System characterized by chronic inflammation, demyelination, gliosis, and neuronal loss. The disease is approximately threefold more common in women than men. The age of onset is typically between 20 and 40 years. Approximately 10% of cases begin before age18 years of age, and a small percentage of cases begin before the age of 10 years. While multiple sclerosis onset after the age of 50, termed late-onset multiple sclerosis occurs in approximately 5% of the population. Methodology: We conducted this cross-sectional observational study using medical records on iMedÂź data base of Centro Hospitalar Cova da Beira. Results: The sample is composed by 108 patients, 77 women and 31 men. The age range was between 19 and 82 years, with mean in 48,35 years. We found a higher prevalence of the disease in women with a woman /man ratio of 2.48: 1. The mean age at the onset of the disease is slightly higher in males (36.18) compared to females (33,97). These are not significantly different between the two groups (p = 0.354). The first most commons symptoms in this population are motor (40,7%) and visual (33.3%) disturbances. As for the course of the disease 70.4% of our patients have RRMS, 14.8% SPMS, 6.5% PPMS and PRMS 1.9%. The Expanded Disability Status Scale in this population have values between 0 and 9 with a mean of 2,091. Patients who had an inaugural progressive course have the average age at onset of disease significantly higher (p= 0.00215) to those who had not. Although 9 of our patients had late onset multiple sclerosis, only 2 had early progression. Conclusion: It is concluded that the characteristics of our population and the variables studied are not very different from those observed in international studies. The exception to this generalization is the highest frequency of EMIT compared to other international studies.
Description
Keywords
Doença Desmielinizante Epidemiologia Esclerose MĂșltipla