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Abstract(s)
Sendo o farmacêutico um profissional de saúde muito próximo da população e que integra equipas multidisciplinares, o Mestrado Integrado em Ciências Farmacêuticas está organizado de forma a permitir o contacto dos futuros farmacêuticos com as principais vertentes da profissão. Assim, o presente trabalho divide-se em três capítulos: Capítulo I – projeto de investigação desenvolvido; Capítulo II e III – relatórios dos estágios em farmácia hospitalar e comunitária, respetivamente.
No Capítulo I foi feita uma abordagem sobre os novos anticoagulantes orais, de forma a expor as vantagens dos inibidores da trombina (dabigatrano) e do fator Xa (rivaroxabano, apixabano e edoxabano). Estes são administrados por via oral, em doses fixas, sem haver necessidade de monitorização regular e apresentam poucas interações medicamentosas. Por estes motivos começaram a ser considerados uma alternativa viável à varfarina – anticoagulante mais prescrito.
Os ensaios clínicos publicados compararam cada um dos fármacos às terapêuticas convencionais. Os resultados revelam uma eficácia equivalente na prevenção de acidentes vasculares cerebrais e tromboembolismos e um perfil de segurança bastante favorável, notando-se que, em alguns casos, os novos anticoagulantes causam menos hemorragias.
Foi objetivo deste trabalho, também, o estudo das prescrições dos novos fármacos em doentes internados no Centro Hospitalar Universitário Cova da Beira, sendo possível afirmar que a sua utilização é crescente e ultrapassou o consumo de varfarina, no período de estudo.
O Capítulo II relata as diferentes funções do farmacêutico em meio hospitalar, desempenhadas no estágio no Centro Hospitalar de Trás-os-Montes e Alto Douro, desde dia 22 de janeiro a 16 de março. Como futura profissional, o contacto com o ambiente hospitalar foi importante para aprofundar conhecimentos acerca de terapias farmacológicas específicas e exclusivas de hospitais.
No Capítulo III são descritas as ações desenvolvidas enquanto estagiária na Farmácia Barreira, durante o período de 19 de março a 1 de junho. Estas permitiram-me percecionar a relevância da interação farmacêutico-utente e do acompanhamento das terapêuticas, tendo sempre presente o espírito de missão e humanidade que a profissão acarreta.
Being the pharmacist a health professional in close contact with the population and integrated in multidisciplinary teams, the Integrated Master’s Degree in Pharmaceutical Sciences is organized to allow the contact of future professionals with the main dimensions of the profession. Therefore, this work is divided in three chapters: Chapter I – investigation project carried out; Chapters II and III – internship reports in hospital and community pharmacy, respectively. In Chapter I, an approach to novel oral anticoagulants has been made, in order to show the advantages of the thrombin inhibitors (dabigatran) and factor Xa (rivaroxaban, apixaban and edoxaban). These are administered orally, in fixed doses, without the need for regular monitoring and they present few drug interactions. For these reasons, they started to be considered a viable alternative to warfarin – the most prescribed anticoagulant. The published clinical trials compare each of the drugs to conventional therapeutics. The results reveal an equivalent efficiency in the prevention of stroke and thromboembolisms and a quite favourable security profile showing that, in some cases, the novel anticoagulants cause fewer bleedings. The study of the prescription of these new medicines in the Centro Hospitalar Universitário da Cova da Beira was also a goal of this work and it is possible to say that its use is increasing and has exceeded the consumption of warfarin, in the period studied. Chapter II describes the different duties of the pharmacist in hospital setting, carried out during the internship in the Centro Hospitalar de Trás-os-Montes e Alto Douro, from January 22nd to March 25th. As a future professional, the contact with hospital environment was important to deepen knowledge about specific pharmaceutical therapies exclusive to hospitals. In Chapter III are described the activities undertaken as a trainee at Farmácia Barreira during the period between March 19th and June 1st. These activities allowed me to realize the relevance of the interaction pharmacist-user and therapy follow up, always bearing in mind the sense of commitment and humanity that the profession entails.
Being the pharmacist a health professional in close contact with the population and integrated in multidisciplinary teams, the Integrated Master’s Degree in Pharmaceutical Sciences is organized to allow the contact of future professionals with the main dimensions of the profession. Therefore, this work is divided in three chapters: Chapter I – investigation project carried out; Chapters II and III – internship reports in hospital and community pharmacy, respectively. In Chapter I, an approach to novel oral anticoagulants has been made, in order to show the advantages of the thrombin inhibitors (dabigatran) and factor Xa (rivaroxaban, apixaban and edoxaban). These are administered orally, in fixed doses, without the need for regular monitoring and they present few drug interactions. For these reasons, they started to be considered a viable alternative to warfarin – the most prescribed anticoagulant. The published clinical trials compare each of the drugs to conventional therapeutics. The results reveal an equivalent efficiency in the prevention of stroke and thromboembolisms and a quite favourable security profile showing that, in some cases, the novel anticoagulants cause fewer bleedings. The study of the prescription of these new medicines in the Centro Hospitalar Universitário da Cova da Beira was also a goal of this work and it is possible to say that its use is increasing and has exceeded the consumption of warfarin, in the period studied. Chapter II describes the different duties of the pharmacist in hospital setting, carried out during the internship in the Centro Hospitalar de Trás-os-Montes e Alto Douro, from January 22nd to March 25th. As a future professional, the contact with hospital environment was important to deepen knowledge about specific pharmaceutical therapies exclusive to hospitals. In Chapter III are described the activities undertaken as a trainee at Farmácia Barreira during the period between March 19th and June 1st. These activities allowed me to realize the relevance of the interaction pharmacist-user and therapy follow up, always bearing in mind the sense of commitment and humanity that the profession entails.
Description
Keywords
Apixaban Dabigatran Edoxaban. Noacs Novel Oral Anticoagulants Rivaroxaban