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Advisor(s)
Abstract(s)
O Exercício Físico tem inúmeros efeitos benéficos comprovados na saúde, e como
tal, é uma arma reconhecida e bem aceite no combate a um grande leque de doenças. A
contração muscular, que ocorre durante a prática de exercício, é um estímulo importante
para a produção e secreção de uma grande variedade de biomoléculas. Destas, destacamse as mioquinas: citoquinas produzidas pelas fibras musculares, que medeiam interações
de forma autócrina, parácrina e/ou endócrina, entre o músculo esquelético e os demais
tecidos do corpo. Ao longo das últimas décadas, os estudos acerca dos efeitos benéficos
mediados por estas mioquinas levaram ao seu reconhecimento como potenciais
candidatas ao tratamento de diversas patologias. Por ser das mais bem conhecidas e por
estar próxima da utilização terapêutica, esta revisão foca numa das milhares de
mioquinas conhecidas até ao momento: a Irisina. Uma mioquina descoberta
recentemente, induzida pelo exercício físico, com diversos efeitos positivos já conhecidos
a nível do tecido adiposo, neurológico, oncológico, cardiovascular, ósseo e outros. Esta
dissertação tem como objetivo fazer uma revisão abrangente da literatura existente sobre
esses efeitos, abordando também o conhecimento até agora disponível sobre a estrutura,
produção, secreção, metabolismo e distribuição desta mioquina no organismo. Por fim,
devido aos avanços e à importância dos conhecimentos obtidos acerca do papel da Irisina
no metabolismo ósseo, é-lhe dedicado um capítulo em separado.
Physical Exercise has numerous beneficial effects on health, and as such, it is wellrecognized and accepted in the fight against a wide range of diseases. Muscle contraction, which occurs during exercise, is an important stimulus for the production and secretion of a grand variety of biomolecules. Of these, myokines stand out: cytokines produced by muscle fibers, which mediate interactions, in an autocrine, paracrine and/or endocrine way, between skeletal muscle and other body tissues. Over the last few decades, studies on the beneficial effects mediated by these myokines have led to their recognition as potential candidates for the treatment of various pathologies. Because it is one of the best known and is bound for therapeutic application, this review focuses one of the thousands of recognized myokines: Irisin. A recently discovered myokine, induced by physical exercise, with several known positive effects on adipose, neurological, oncological, cardiovascular, bone tissue and others. This dissertation aims to make a comprehensive review of the existing literature on these effects, also addressing the knowledge available so far on the structure, production, secretion, metabolism and distribution of this myokine in the body. Finally, due to the advancements and importance of knowledge obtained about the role of irisin in bone metabolism, a separate chapter is dedicated to it.
Physical Exercise has numerous beneficial effects on health, and as such, it is wellrecognized and accepted in the fight against a wide range of diseases. Muscle contraction, which occurs during exercise, is an important stimulus for the production and secretion of a grand variety of biomolecules. Of these, myokines stand out: cytokines produced by muscle fibers, which mediate interactions, in an autocrine, paracrine and/or endocrine way, between skeletal muscle and other body tissues. Over the last few decades, studies on the beneficial effects mediated by these myokines have led to their recognition as potential candidates for the treatment of various pathologies. Because it is one of the best known and is bound for therapeutic application, this review focuses one of the thousands of recognized myokines: Irisin. A recently discovered myokine, induced by physical exercise, with several known positive effects on adipose, neurological, oncological, cardiovascular, bone tissue and others. This dissertation aims to make a comprehensive review of the existing literature on these effects, also addressing the knowledge available so far on the structure, production, secretion, metabolism and distribution of this myokine in the body. Finally, due to the advancements and importance of knowledge obtained about the role of irisin in bone metabolism, a separate chapter is dedicated to it.
Description
Keywords
Irisina Mioquinas Osso