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Advisor(s)
Abstract(s)
A doença de Parkinson é uma doença degenerativa e progressiva do sistema nervoso central, tornando-se frequentemente incapacitante. A estimulação cirúrgica dos núcleos da base constitui mais uma opção terapêutica.
Atualmente, a estimulação cerebral profunda é o procedimento cirúrgico mais usado na doença de Parkinson. Este procedimento simula os efeitos de uma lesão, sem provocar uma lesão cerebral.
A estimulação cerebral profunda de alta frequência é um procedimento neurocirúrgico que envolve a colocação de elétrodos em regiões profundas do cérebro de modo a que a estimulação elétrica possa lá chegar. Dependendo dos efeitos desejados, vários núcleos subcorticais, como o núcleo ventral intermédio do tálamo, o globo pálido interno, o núcleo subtalâmico, a zona incerta, o núcleo pedúnculo-pontino e até mesmo as áreas corticais, têm sido alvo de estimulação.
A estimulação cerebral profunda do núcleo subtalâmico ou do globo pálido interno pode melhorar a marcha e, deste modo, melhorar significativamente a qualidade de vida de muitos pacientes com doença de Parkinson avançada.
Parkinson’s disease is a progressive degenerative disease of the central nervous system frequently becoming motor disabling. The surgical stimulation of the basal ganglia is one more therapeutic option. Currently, deep brain stimulation is the most common procedure used in Parkinson's disease. This procedure simulates the effects of an injury, without requiring the completion of a brain injury. Deep brain stimulation is a high frequency neurosurgical procedure which involves the placement of electrodes into targeted deep brain regions so electrical stimulation can be delivered. Depending on the desired effects, various subcortical nuclei, such as ventral intermediate nucleus of the thalamus, globus pallidus interna, subthalamic nucleus, zona incerta, and pedunculopontine nucleus, and other subcortical nuclei and even cortical areas, have been targeted for stimulation. Deep brain stimulation of the subthalamic nucleus and globus pallidus interna has been shown to improve gait and thus significantly improve the quality of life of many patients with advanced Parkinson's disease.
Parkinson’s disease is a progressive degenerative disease of the central nervous system frequently becoming motor disabling. The surgical stimulation of the basal ganglia is one more therapeutic option. Currently, deep brain stimulation is the most common procedure used in Parkinson's disease. This procedure simulates the effects of an injury, without requiring the completion of a brain injury. Deep brain stimulation is a high frequency neurosurgical procedure which involves the placement of electrodes into targeted deep brain regions so electrical stimulation can be delivered. Depending on the desired effects, various subcortical nuclei, such as ventral intermediate nucleus of the thalamus, globus pallidus interna, subthalamic nucleus, zona incerta, and pedunculopontine nucleus, and other subcortical nuclei and even cortical areas, have been targeted for stimulation. Deep brain stimulation of the subthalamic nucleus and globus pallidus interna has been shown to improve gait and thus significantly improve the quality of life of many patients with advanced Parkinson's disease.
Description
Keywords
Doença de Parkinson Estimulação Cerebral Profunda Neurocirurgia Prognóstico Tratamento