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Abstract(s)
Atualmente tem-se verificado um aumento do número de diagnósticos de depressão,
bem como da sua associação a riscos de suicídio dos indivíduos. Esta perturbação do
humor possui uma elevada influência na qualidade de vida e capacidade funcional, além
da sua associação a uma elevada percentagem de doentes que não responde aos
tratamentos atuais ou à recorrência de sintomas. Por isso, o enfoque nos últimos anos,
tem sido no desenvolvimento de novas abordagens terapêuticas e avaliar novos
mecanismos de doença que permitam aprimorar o diagnóstico e acompanhamento dos
indivíduos. O microbioma tem demonstrado ser de grande importância tanto para o
desenvolvimento da depressão, como também da evolução e resolução da mesma, onde
diversas teorias têm explicado a sua associação não só à patologia depressiva, como
também a outras patologias de saúde mental. Esta interação poderá, ainda, levar ao
desenvolvimento de novas abordagens terapêuticas, de modo a auxiliar a mitigação dos
sintomas. Por conseguinte, esta monografia tem como objetivo analisar as diferentes
vertentes que caracterizam a interação entre o microbioma intestinal e a depressão, bem
como a possibilidade de realização de novas abordagens para esta patologia.
Currently, there has been an increasing number of cases of depression, as well as it’s association to suicide risks for the individuals. This mood disorder has a high influence in quality of life and funcional capacity, as well as an association to a high percentagem of patients that do not respond to current treatment options, or have recurring symptoms. Therefore, the focus during the last decades resides in the development of new treatment options and studying new disease mechanisms that can allow and improve diagnostics and follow-up. The microbiome has revealed to be of great significance for the development of this disturbance, as well as it’s evolution and resolution, where diferent theories have been used to explain it’s association, not only to depression, but as well as other mental health pathologies. This interaction might lead to the development of new treatment options, mitigating the symptoms of depression. Therefore, this monography aims to analyse the diferente aspects that characterize the interaction between the gut microbiome and depression, as well as the possibility of creating new approaches to this disturbance.
Currently, there has been an increasing number of cases of depression, as well as it’s association to suicide risks for the individuals. This mood disorder has a high influence in quality of life and funcional capacity, as well as an association to a high percentagem of patients that do not respond to current treatment options, or have recurring symptoms. Therefore, the focus during the last decades resides in the development of new treatment options and studying new disease mechanisms that can allow and improve diagnostics and follow-up. The microbiome has revealed to be of great significance for the development of this disturbance, as well as it’s evolution and resolution, where diferent theories have been used to explain it’s association, not only to depression, but as well as other mental health pathologies. This interaction might lead to the development of new treatment options, mitigating the symptoms of depression. Therefore, this monography aims to analyse the diferente aspects that characterize the interaction between the gut microbiome and depression, as well as the possibility of creating new approaches to this disturbance.
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Keywords
Depressão Eixocérebrointestino Microbioma Microbiomaintestinal Psiquiatria