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Abstract(s)
Introdução: A determinação do prognóstico na altura do diagnóstico de cancro da mama é essencial para um ótimo acompanhamento do doente. Concomitantemente com os fatores prognósticos tradicionais, o valor prognóstico dos marcadores tumorais tem sido investigado. Os marcadores mais utilizados no cancro da mama são o Ca 15.3 e o CEA e apesar de alguns estudos sugerirem que os níveis séricos destes marcadores facultam informações prognósticas significativas, sua utilidade permanece controversa.
Objetivos: Determinar se o doseamento sérico dos marcadores tumorais Ca 15.3 e CEA na altura do diagnóstico tem valor prognóstico na recorrência em 5 anos do cancro da mama, numa população de utentes do género feminino, do serviço de Ginecologia do Centro Hospitalar Cova da Beira, com diagnóstico de cancro da mama.
Material e Métodos: Estudo de investigação de carácter descritivo, transversal, com direção retrospetiva. Para a sua realização foram consultados os processos clínicos das utentes com diagnóstico de cancro da mama, do serviço de Ginecologia do Centro Hospitalar Cova da Beira, entre 1 de janeiro de 2005 e 31 de dezembro de 2010. Para a análise estatística recorreu-se ao programa informático Microsoft Excel 2016 e ao software SPSS -Statistical Package for Social Sciences ® (versão 23.0).
Resultados: A amostra foi constituída por 80 mulheres, com idade mediana de 66,5 anos. 85% das mulheres tinham carcinomas ductais invasivos. Relativamente à classificação TNM, o T mais frequentes foi o T2 (46,3%) e o N mais frequente foi o N0 (56,3%). No que diz respeito ao estadiamento, 45% das mulheres encontravam-se no estadio II. 25% das mulheres apresentavam o Ca 15.3 elevado na altura do diagnóstico, e a mesma percentagem apresentava CEA elevado. Apenas 10% tinham os dois marcadores elevados. Houve recorrência da doença em 21,2% dos casos. 13 mulheres tiveram recorrência à distância, sendo a localização mais frequente o osso. A relação entre o tamanho do tumor e a recorrência da doença à distância foi estatisticamente significativa (p<0,009). Não se obteve significância estatística ao relacionar o Ca 15.3 e o CEA com recorrência da doença, nem com a localização das recorrências. Houve uma relação estatisticamente significativa entre a metastização óssea e ambos os marcadores estarem elevados (p< 0,048) e entre metastização ovárica e o marcador Ca 15.3 estar aumentado (p<0,017).
Conclusão: Com base nos resultados obtidos, não podemos considerar os níveis pré-operatórios dos marcadores tumorais Ca 15.3 e CEA como fatores prognósticos de recorrência de cancro da mama.
Introduction: Determining the prognosis at the time of breast cancer diagnosis is essential for optimal patient follow-up. Concomitant with traditional prognostic factors, the prognostic value of tumor markers has been investigated. The most commonly used markers in breast cancer are Ca 15.3 and CEA, and although some studies suggest that elevated serum levels of these markers provide significant prognostic information, their usefulness remains controversial. Objective: To determine if the serum levels of tumor markers Ca 15.3 and CEA at the time of diagnosis has a prognostic value in the 5-year recurrence of breast cancer in a population of female patients from the Department of Gynecology of CHCB, diagnosed with breast cancer. Material and methods: Cross-sectional and retrospective study with a descriptive component. The medical records from the Department of Gynecology of CHCB regarding all patients diagnosed with breast cancer between 1st January of 2005 and 31st December of 2010 were consulted. Microsoft Excel 2016 and software SPSS -Statistical Package for Social Sciences ® (version 23.0) were used for the statistical analysis. Results: The sample consisted of 80 women, with a median age of 66,5 years. 85% of the women had invasive ductal carcinomas. As far as the TNM classification is concerned the most frequent T was T2 (46.3%) and the most frequent N was N0 (56.3%). With regard to staging, 45% of the women were in stage II. 25% of the women had the serum marker Ca 15.3 elevated at the time of diagnosis. The CEA marker was also elevated in 25% of women. Only 10% had both markers elevated. 21.2% of the women had recurrence of the primary disease. 13 women had distant recurrences, the most frequent location being the bone. The relationship between tumor size and distant recurrence of disease was statistically significant (p <0.009). No statistical significance was obtained by correlating markers Ca 15.3 and CEA with recurrence of the disease, nor with the location of recurrences. There was a statistically significant relationship between bone metastasis and both markers being elevated (p <0.048) and between ovarian metastasis and increased Ca 15.3 (p <0.017). Conclusion: Based on the results obtained, we can’t consider the preoperative levels of tumor markers Ca 15.3 and CEA as prognostic factors for recurrence of breast cancer.
Introduction: Determining the prognosis at the time of breast cancer diagnosis is essential for optimal patient follow-up. Concomitant with traditional prognostic factors, the prognostic value of tumor markers has been investigated. The most commonly used markers in breast cancer are Ca 15.3 and CEA, and although some studies suggest that elevated serum levels of these markers provide significant prognostic information, their usefulness remains controversial. Objective: To determine if the serum levels of tumor markers Ca 15.3 and CEA at the time of diagnosis has a prognostic value in the 5-year recurrence of breast cancer in a population of female patients from the Department of Gynecology of CHCB, diagnosed with breast cancer. Material and methods: Cross-sectional and retrospective study with a descriptive component. The medical records from the Department of Gynecology of CHCB regarding all patients diagnosed with breast cancer between 1st January of 2005 and 31st December of 2010 were consulted. Microsoft Excel 2016 and software SPSS -Statistical Package for Social Sciences ® (version 23.0) were used for the statistical analysis. Results: The sample consisted of 80 women, with a median age of 66,5 years. 85% of the women had invasive ductal carcinomas. As far as the TNM classification is concerned the most frequent T was T2 (46.3%) and the most frequent N was N0 (56.3%). With regard to staging, 45% of the women were in stage II. 25% of the women had the serum marker Ca 15.3 elevated at the time of diagnosis. The CEA marker was also elevated in 25% of women. Only 10% had both markers elevated. 21.2% of the women had recurrence of the primary disease. 13 women had distant recurrences, the most frequent location being the bone. The relationship between tumor size and distant recurrence of disease was statistically significant (p <0.009). No statistical significance was obtained by correlating markers Ca 15.3 and CEA with recurrence of the disease, nor with the location of recurrences. There was a statistically significant relationship between bone metastasis and both markers being elevated (p <0.048) and between ovarian metastasis and increased Ca 15.3 (p <0.017). Conclusion: Based on the results obtained, we can’t consider the preoperative levels of tumor markers Ca 15.3 and CEA as prognostic factors for recurrence of breast cancer.
Description
Keywords
Cancro da Mama Fatores Prognósticos Marcadores Tumorais Recorrências