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Abstract(s)
A sĂndrome cardiorenal consiste na interação patolĂłgica entre o coração e o rim, onde a insuficiĂȘncia de um destes ĂłrgĂŁos causa o aparecimento ou agravamento de lesĂŁo no outro.
Atualmente Ă© classificada em 5 tipos, dos quais apenas o primeiro e o terceiro sĂŁo agudos. No tipo 1, a falĂȘncia cardĂaca aguda resulta em lesĂŁo renal aguda. No tipo 3, ocorre disfunção cardĂaca precipitada por uma queda primĂĄria da função renal.
Observando de uma perspetiva clĂnica, a sĂndrome cardiorenal ganha especial importĂąncia, pois a mortalidade dos pacientes com insuficiĂȘncia cardĂaca aumenta na presença de uma taxa de filtração glomerular reduzida e os pacientes com doença renal crĂłnica apresentam risco aumentado de desenvolverem doença cardiovascular.
A fisiopatologia continua a ser estudada, mas parece haver contributos hemodinĂąmicos e nĂŁo hemodinĂąmicos.
O tratamento ainda nĂŁo estĂĄ completamente definido, mas o alĂvio da congestĂŁo Ă© o objetivo principal, sendo os diurĂ©ticos os fĂĄrmacos de primeira linha no SCR.
The cardiorenal syndrome is defined as the pathological interaction between the heart and the kidney, where the failure of one of these organs causes worsening of the others function. It is currently classified as 5 subtypes, of which only the 1st and 3rd are acute. In type 1, heart failure provokes acute renal injury. In type 3, there is a worsening of heart function, brought about by acute kidney injury. From a clinicianâs point of view, the cardiorenal syndrome gains special importance, as mortality of patients with heart failure rises in the presence of low glomerular filtration rate, and those with kidney injury are more likely to develop cardiovascular disease. Pathophysiology continues to be investigated, however it appears that both hemodynamic and non-hemodynamic factors contribute to it. Treatment is still not completely defined, but congestion relief is the main goal, with diuretics being the 1st choice for managing CRS.
The cardiorenal syndrome is defined as the pathological interaction between the heart and the kidney, where the failure of one of these organs causes worsening of the others function. It is currently classified as 5 subtypes, of which only the 1st and 3rd are acute. In type 1, heart failure provokes acute renal injury. In type 3, there is a worsening of heart function, brought about by acute kidney injury. From a clinicianâs point of view, the cardiorenal syndrome gains special importance, as mortality of patients with heart failure rises in the presence of low glomerular filtration rate, and those with kidney injury are more likely to develop cardiovascular disease. Pathophysiology continues to be investigated, however it appears that both hemodynamic and non-hemodynamic factors contribute to it. Treatment is still not completely defined, but congestion relief is the main goal, with diuretics being the 1st choice for managing CRS.
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Keywords
Cardiorenal Fisiopatologia InsuficiĂȘncia CardĂaca InsuficiĂȘncia Renal Tratamento