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Abstract(s)
A presente dissertação investiga a relação entre doenças inflamatórias intestinais (DII) e
colangiopatias esclerosantes, com particular ênfase na colangite esclerosante primária
(CEP). A CEP é uma doença colestática crónica do fígado, frequentemente associada a
DII, especialmente a colite ulcerosa (CU). A pesquisa explora a etiologia, fisiopatologia,
diagnóstico, diagnóstico diferencial, tratamento e controlo destas condições, bem como,
as suas implicações clínicas.
O estudo destaca que aproximadamente 75% dos pacientes com CEP também
apresentam DII, e que estes pacientes têm um risco aumentado de desenvolver neoplasia
colorretal. A dissertação utiliza uma revisão extensa da literatura para examinar a
predisposição genética e ambiental partilhada entre CEP e DII, assim como, o impacto
do microbioma intestinal e a comunicação intestino-fígado na patogénese destas
doenças.
A metodologia empregue inclui a análise de 117 artigos selecionados de uma pesquisa
inicial de 242 publicações na base de dados PubMed, focando em artigos de revisão,
guidelines e estudos randomizados controlados. O objetivo é avançar no entendimento
destas doenças complexas e contribuir para o desenvolvimento de abordagens
terapêuticas mais eficazes.
The present dissertation investigates the relationship between inflammatory bowel diseases (IBD) and sclerosing cholangiopathies, with particular emphasis on primary sclerosing cholangitis (PSC). PSC is a chronic cholestatic liver disease, often associated with IBD, especially ulcerative colitis (UC). The research explores the etiology, pathophysiology, diagnosis, differential diagnosis, treatment, and management of these conditions, as well as their clinical implications. The study highlights that approximately 75% of patients with PSC also have IBD, and these patients have an increased risk of developing colorectal neoplasia. The dissertation utilizes an extensive literature review to examine the shared genetic and environmental predisposition between PSC and IBD, as well as the impact of the intestinal microbiome and gut-liver communication in the pathogenesis of these diseases. The methodology employed includes the analysis of 117 articles selected from an initial search of 242 publications in the PubMed database, focusing on review articles, guidelines, and randomized controlled trials. The objective is to advance the understanding of these complex diseases and contribute to the development of more effective therapeutic approaches.
The present dissertation investigates the relationship between inflammatory bowel diseases (IBD) and sclerosing cholangiopathies, with particular emphasis on primary sclerosing cholangitis (PSC). PSC is a chronic cholestatic liver disease, often associated with IBD, especially ulcerative colitis (UC). The research explores the etiology, pathophysiology, diagnosis, differential diagnosis, treatment, and management of these conditions, as well as their clinical implications. The study highlights that approximately 75% of patients with PSC also have IBD, and these patients have an increased risk of developing colorectal neoplasia. The dissertation utilizes an extensive literature review to examine the shared genetic and environmental predisposition between PSC and IBD, as well as the impact of the intestinal microbiome and gut-liver communication in the pathogenesis of these diseases. The methodology employed includes the analysis of 117 articles selected from an initial search of 242 publications in the PubMed database, focusing on review articles, guidelines, and randomized controlled trials. The objective is to advance the understanding of these complex diseases and contribute to the development of more effective therapeutic approaches.
Description
Keywords
Colangite Esclerosante Primária Colite
Ulcerosa Diagnóstico Diferencial Doença de Crohn Doenças Inflamatórias Intestinais Microbioma Intestinal Neoplasia Colorretal Tratamento