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Advisor(s)
Abstract(s)
As células de Toker são células epiteliais localizadas na camada basal da epiderme
do mamilo de prevalência rara, estimada em cerca de dez por cento. Mais raramente, estas
células são encontradas em número aumentado, fenómeno conhecido como hiperplasia de
células de Toker. A presença de células de Toker na mama é uma ocorrência natural,
benigna e que geralmente não condiciona alterações cutâneas do complexo areolo-mamilar
nem se associa a achados clínicos significativos. Os casos publicados na literatura sobre a
hiperplasia de células de Toker na mama são escassos. Alguns autores relatam esta entidade
no contexto de Doença de Paget mamária, Doença de Paget extramamária, Disqueratose
Pagetóide e Papulose de Células claras, sendo interpretada como um achado incidental na
biópsia de pele dessas condições.
Apresenta-se um caso confirmado de hiperplasia de células de Toker mamilar, com
pelo menos 17 anos de evolução, com lesão cutânea associada e sem patologia mamária
subjacente, ocorrido no Centro Hospitalar Universitário Cova da Beira. Enfatiza-se a
necessidade de incluir esta rara entidade no diagnóstico diferencial das lesões eczematosas
do mamilo.
Toker cells are clear epithelial cells localized within the basal layer of the nipple epidermis, with a rare prevalence estimated to be around ten per cent. More rarely, these cells are found in increased number, phenomenon known by Toker cell hyperplasia. The presence of breast Toker cells occurs naturally, with a benign course and is nor associated with cutaneous alterations of the nipple-areola complex neither relevant findings in further work-up. Cases reported about Toker cell hyperplasia of the breast are sparse. Some authors refer to Toker cell hyperplasia as in association with mammary Paget Disease, extramammary Paget Disease, Pagetoid Dyskeratosis and Clear Cell Papulosis, an incidental finding in the work-up of the skin biopsies of those conditions. A case confirmed from Centro Hospitalar Universitário Cova da Beira of Toker cell hyperplasia in a nipple, with at least 17-year evolution and associated with cutaneous alterations and no underlying disease, is presented. Moreover, attention is drawn to include this rare entity in the differential diagnosis of inflammatory lesions of the nipple.
Toker cells are clear epithelial cells localized within the basal layer of the nipple epidermis, with a rare prevalence estimated to be around ten per cent. More rarely, these cells are found in increased number, phenomenon known by Toker cell hyperplasia. The presence of breast Toker cells occurs naturally, with a benign course and is nor associated with cutaneous alterations of the nipple-areola complex neither relevant findings in further work-up. Cases reported about Toker cell hyperplasia of the breast are sparse. Some authors refer to Toker cell hyperplasia as in association with mammary Paget Disease, extramammary Paget Disease, Pagetoid Dyskeratosis and Clear Cell Papulosis, an incidental finding in the work-up of the skin biopsies of those conditions. A case confirmed from Centro Hospitalar Universitário Cova da Beira of Toker cell hyperplasia in a nipple, with at least 17-year evolution and associated with cutaneous alterations and no underlying disease, is presented. Moreover, attention is drawn to include this rare entity in the differential diagnosis of inflammatory lesions of the nipple.
Description
Keywords
Alterações Cutâneas Células de Toker Diagnóstico Diferencial Hiperplasia Mamilo