HLA‐A23/HLA‐A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma

MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/predementia (NpD, n = 28), or with dementia (D, n = 28) was studied. Multivariate analysis was used to examine the influence of dementia and HLA class I serotype on sHLA class I levels, and to compare sHLA class I within four groups according to the presence or absence of HLA-A23/A24 and dementia. HLA-A23/A24 and dementia, but not age, significantly influenced the level of sHLA class I. Importantly, the concurrent presence of HLA-A23/A24 and dementia was associated with higher levels of sHLA class I (p < 0.001). This study has shown that the simultaneous presence of HLA-A23/HLA-A24 and dementia is associated with high levels of serum sHLA class I molecules. Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers.

Keywords

Alzheimer's Biomarkers Dementia Immunoregulation Neurodegeneration Parkinson's MHC Soluble HLA class I

URI

http://hdl.handle.net/10400.6/13396

Citation

Cardoso EM, Lourenço-Gomes V, Esgalhado AJ, Reste-Ferreira D, Oliveira N, Amaral AS, Martinho A, Gama JMR, Verde I, Lourenço O, Fonseca AM, Buchli R, Arosa FA. HLA-A23/HLA-A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma. HLA. 2023 Jul 3. doi: 10.1111/tan.15149. Epub ahead of print. PMID: 37400938.