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HLA‐A23/HLA‐A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma

2023Journal article Open access
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dc.contributor.authorCardoso, Elsa M.
dc.contributor.authorGomes, Vânia Lourenço
dc.contributor.authorEsgalhado, André J.
dc.contributor.authorFerreira, Débora Reste
dc.contributor.authorOliveira, Nádia
dc.contributor.authorAmaral, Ana Saraiva
dc.contributor.authorMartinho, António
dc.contributor.authorGama, Jorge
dc.contributor.authorVerde, Ignacio
dc.contributor.authorLourenço, Olga
dc.contributor.authorFonseca, Ana C.
dc.contributor.authorBuchli, Rico
dc.contributor.authorArosa, Fernando A.
dc.date.accessioned2023-07-28T16:12:21Z
dc.date.available2023-07-28T16:12:21Z
dc.date.issued2023
dc.description.abstractMHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/predementia (NpD, n = 28), or with dementia (D, n = 28) was studied. Multivariate analysis was used to examine the influence of dementia and HLA class I serotype on sHLA class I levels, and to compare sHLA class I within four groups according to the presence or absence of HLA-A23/A24 and dementia. HLA-A23/A24 and dementia, but not age, significantly influenced the level of sHLA class I. Importantly, the concurrent presence of HLA-A23/A24 and dementia was associated with higher levels of sHLA class I (p < 0.001). This study has shown that the simultaneous presence of HLA-A23/HLA-A24 and dementia is associated with high levels of serum sHLA class I molecules. Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCardoso EM, Lourenço-Gomes V, Esgalhado AJ, Reste-Ferreira D, Oliveira N, Amaral AS, Martinho A, Gama JMR, Verde I, Lourenço O, Fonseca AM, Buchli R, Arosa FA. HLA-A23/HLA-A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma. HLA. 2023 Jul 3. doi: 10.1111/tan.15149. Epub ahead of print. PMID: 37400938.pt_PT
dc.identifier.doi10.1111/tan.15149pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/13396
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFUNCTIONAL AND TRANSCRIPTIONAL CHARACTERIZATION OF HUMAN EFFECTOR-MEMORY CD8+ T CELLS: IMPLICATIONS FOR HUMAN COGNITION
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAlzheimer'spt_PT
dc.subjectBiomarkerspt_PT
dc.subjectDementiapt_PT
dc.subjectImmunoregulationpt_PT
dc.subjectNeurodegenerationpt_PT
dc.subjectParkinson'spt_PT
dc.subjectMHCpt_PT
dc.subjectSoluble HLA class Ipt_PT
dc.titleHLA‐A23/HLA‐A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasmapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFUNCTIONAL AND TRANSCRIPTIONAL CHARACTERIZATION OF HUMAN EFFECTOR-MEMORY CD8+ T CELLS: IMPLICATIONS FOR HUMAN COGNITION
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151022%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.citation.titleHLApt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePereira de Oliveira Cardoso
person.familyNameGabriel Esgalhado
person.familyNameReste Ferreira
person.familyNameOliveira
person.familyNameSaraiva Amaral
person.familyNameMARTINHO
person.familyNameReis Gama
person.familyNameVerde
person.familyNameLourenço
person.familyNameAmaral Loureiro da Fonseca
person.familyNameBuchli
person.familyNameArosa
person.givenNameElsa Maria
person.givenNameAndré João
person.givenNameDébora Alexandra
person.givenNameNádia
person.givenNameAna Paula
person.givenNameANTONIO
person.givenNameJorge Manuel
person.givenNameIgnacio
person.givenNameOlga Maria Marques
person.givenNameAna Clotilde
person.givenNameRico
person.givenNameFernando
person.identifierAAL-5774-2020
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person.identifier.ridM-3991-2013
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person.identifier.scopus-author-id57201150290
person.identifier.scopus-author-id55913729400
person.identifier.scopus-author-id6604045863
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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